Journal for ImmunoTherapy of Cancer

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Systemic and local immunity following adoptive transfer of NY-ESO-1 SPEAR T cells in synovial sarcoma
Journal for ImmunoTherapy of Cancer - Tập 7 - Trang 1-14 - 2019
Indu Ramachandran, Daniel E. Lowther, Rebecca Dryer-Minnerly, Ruoxi Wang, Svetlana Fayngerts, Daniel Nunez, Gareth Betts, Natalie Bath, Alex J. Tipping, Luca Melchiori, Jean-Marc Navenot, John Glod, Crystal L. Mackall, Sandra P. D’Angelo, Dejka M. Araujo, Warren A. Chow, George D. Demetri, Mihaela Druta, Brian A. Van Tine, Stephan A. Grupp, Albiruni R. Abdul Razak, Breelyn Wilky, Malini Iyengar, Trupti Trivedi, Erin Van Winkle, Karen Chagin, Rafael Amado, Gwendolyn K. Binder, Samik Basu
Gene-modified autologous T cells expressing NY-ESO-1c259, an affinity-enhanced T-cell receptor (TCR) reactive against the NY-ESO-1-specific HLA-A*02-restricted peptide SLLMWITQC (NY-ESO-1 SPEAR T-cells; GSK 794), have demonstrated clinical activity in patients with advanced synovial sarcoma (SS). The factors contributing to gene-modified T-cell expansion and the changes within the tumor microenvir... hiện toàn bộ
TLR9 acts as a sensor for tumor-released DNA to modulate anti-tumor immunity after chemotherapy
Journal for ImmunoTherapy of Cancer - Tập 7 - Trang 1-8 - 2019
Tae Heung Kang, Chih-Ping Mao, Young Seob Kim, Tae Woo Kim, Andrew Yang, Brandon Lam, Ssu-Hsueh Tseng, Emily Farmer, Yeong-Min Park, Chien-Fu Hung
The tumor microenvironment exists in a state of dynamic equilibrium, in which a balance of agonist and antagonist signals govern the anti-tumor immune responses. Previous studies have shown that chemotherapy could shift this balance in favor of agonistic signals for the anti-tumor immune responses mounted by CD8+ cytotoxic T lymphocytes (CTL), providing sufficiently high antigen density within the... hiện toàn bộ
Interrogating the interactions between myeloid derived suppressor cells and cancer stem cells in glioblastoma
Journal for ImmunoTherapy of Cancer - - 2013
Balint Otvos, James H. Finke, Michael Vogelbaum, Justin D. Lathia
Whole-blood RNA transcript-based models can predict clinical response in two large independent clinical studies of patients with advanced melanoma treated with the checkpoint inhibitor, tremelimumab
Journal for ImmunoTherapy of Cancer - Tập 5 - Trang 1-9 - 2017
Philip Friedlander, Karl Wassmann, Alan M. Christenfeld, David Fisher, Chrisann Kyi, John M. Kirkwood, Nina Bhardwaj, William K. Oh
Tremelimumab is an antibody that blocks CTLA-4 and demonstrates clinical efficacy in a subset of advanced melanoma patients. An unmet clinical need exists for blood-based response-predictive gene signatures to facilitate clinically effective and cost-efficient use of such immunotherapeutic interventions. Peripheral blood samples were collected in PAXgene® tubes from 210 treatment-naïve melanoma pa... hiện toàn bộ
The density and spatial tissue distribution of CD8+ and CD163+ immune cells predict response and outcome in melanoma patients receiving MAPK inhibitors
Journal for ImmunoTherapy of Cancer - Tập 7 - Trang 1-13 - 2019
Daniela Massi, Eliana Rulli, Mara Cossa, Barbara Valeri, Monica Rodolfo, Barbara Merelli, Francesco De Logu, Romina Nassini, Michele Del Vecchio, Lorenza Di Guardo, Roberta De Penni, Michele Guida, Vanna Chiarion Sileni, Anna Maria Di Giacomo, Marco Tucci, Marcella Occelli, Francesca Portelli, Viviana Vallacchi, Francesca Consoli, Pietro Quaglino, Paola Queirolo, Gianna Baroni, Fabrizio Carnevale-Schianca, Laura Cattaneo, Alessandro Minisini, Giuseppe Palmieri, Licia Rivoltini, Mario Mandalà
Clinical response to MAPK inhibitors in metastatic melanoma patients is heterogeneous for reasons still needing to be elucidated. As the patient immune activity contributes to treatment clinical benefit, the pre-existing level of immunity at tumor site may provide biomarkers of disease outcome to therapy. Here we investigated whether assessing the density and spatial tissue distribution of key imm... hiện toàn bộ
Associations of Fc gamma receptor (FcgR2a, FcgR3a and FcgR2c) genotype with outcome in metastatic renal cell carcinoma (mRCC) patients receiving high dose interleukin 2 (HD-IL2)
Journal for ImmunoTherapy of Cancer - Tập 3 Số S2 - 2015
Amy K. Erbe, Wei Wang, Kyung Mann Kim, L. David Carmichael, MIkayla Gallendberger, Dustin Hess, Eneida A. Mendonça, Younghwan Song, Jacquelyn A. Hank, Su-Chun Chen, Sabina Signoretti, Michael B. Atkins, Alexander Carlson, James W. Mier, David J. Panka, David F. McDermott, Paul M. Sondel
MICA immune complex formed with alpha 3 domain-specific antibody activates human NK cells in a Fc-dependent manner
Journal for ImmunoTherapy of Cancer - Tập 7 - Trang 1-13 - 2019
Changchun Du, Jack Bevers, Ryan Cook, T. Noelle Lombana, Kamalakannan Rajasekaran, Marissa Matsumoto, Christoph Spiess, Jeong M. Kim, Zhengmao Ye
One of the mechanisms by which tumors evade immune surveillance is through shedding of the major histocompatibility complex (MHC) class I chain-related protein A and B (MICA/B) from their cell surface. MICA/B are ligands for the activating receptor NKG2D on NK and CD8 T cells. This shedding reduces cell surface levels of MICA/B and impairs NKG2D recognition. Shed MICA/B can also mask NKG2D recepto... hiện toàn bộ
Hypoxia-induced soluble CD137 in malignant cells blocks CD137L-costimulation as an immune escape mechanism
Journal for ImmunoTherapy of Cancer - Tập 2 - Trang 1-1 - 2014
Sara Labiano, Asis Palazon, Elixabet Bolaños-Mateo, Arantza Azpilicueta, Alfonso Rodriguez, Aizea Morales-Kastresana, Elena Marin, Alfonso Gurpide, Maria Rodriguez-Ruiz, M Angela Aznar, Maria Jure-Kunkel, Ignacio Melero
Uncovering a novel function of BTLA on tumor-infiltrating CD8+ T cells
Journal for ImmunoTherapy of Cancer - Tập 1 Số S1 - 2013
Cara L. Haymaker, Richard C. Wu, Krit Ritthipichai, Chantale Bernatchez, Marie-Andrée Forget, Jie Qing Chen, Hiu Liu, Ena Wang, Francesco M. Marincola, Patrick Hwu, Laszlo G. Radvanyi
A phase I study of an agonist anti-CD27 human antibody (CDX-1127) in patients with advanced hematologic malignancies or solid tumors
Journal for ImmunoTherapy of Cancer - Tập 1 - Trang 1-1 - 2013
Stephen Ansell, Donald Northfelt, Ian Flinn, Howard Burris, Shira Dinner, Victor Villalobos, Branimir Sikic, Lana Pilja, Michael Yellin, Tibor Keler, Thomas Davis
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