Mahmoud-Sobhy Elkhwanky, Outi Kummu, Terhi Piltonen, Johanna Laru, Laure Morin‐Papunen, Maija Mutikainen, Pasi Tavi, Jukka Hakkola
ABSTRACTLow plasma level of 25‐hydroxyvitamin D (25‐OH‐D), namely vitamin D deficiency, is associated with obesity and weight loss improves 25‐OH‐D status. However, the mechanism behind obesity‐induced vitamin D deficiency remains unclear. Here, we report that obesity suppresses the expression of cytochrome P450 (CYP) 2R1, the main vitamin D 25‐hydroxylase, in both...... hiện toàn bộ
Christian Roux, Thierry Thomas, Julien Paccou, Geoffray Bizouard, Anne Crochard, Emese Tóth, Magali Lemaître, F. Maurel, L. Perrin, Florence Tubach
ABSTRACTSevere osteoporotic fractures (hip, proximal humerus, pelvic, vertebral and multiple rib fractures) carry an increased risk of mortality. This retrospective cohort study in the French national healthcare database aimed to estimate refracture and mortality rates after severe osteoporotic fractures at different sites, and to identify mortality‐related variabl...... hiện toàn bộ
Christopher M. Cirnigliaro, Michael F. La Fountaine, J. Scott Parrott, Steven Kirshblum, Cristin McKenna, Susan J. Sauer, Sue A. Shapses, Lihong Hao, Isa A. McClure, Joshua C. Hobson, Ann M. Spungen, William A. Bauman
ABSTRACTPersons with neurologically motor‐complete spinal cord injury (SCI) have a marked loss of bone mineral density (BMD) of the long bones of the lower extremities, predisposing them to fragility fractures, especially at the knee. Denosumab, a commercially available human monoclonal IgG antibody to receptor activator of nuclear factor‐κB ligand (RANKL), may pro...... hiện toàn bộ
ABSTRACTExcluding clinical trials, there is limited evidence on the effect of 12 months of romosozumab treatment on bone mineral density (BMD) increase in real‐world clinical practice because its use has only been approved recently. Thus, this study aimed to investigate the real‐world effect of 12 months of romosozumab treatment on BMD increase and identify factors...... hiện toàn bộ
Benjamin Rush, Neil Binkley, Diane Krueger, Yosuke Yamada, Adam J. Kuchnia
ABSTRACTTraditional diagnostic criteria for sarcopenia use dual‐energy X‐ray absorptiometry (DXA)‐measured appendicular lean mass (ALM), normalized to height (ALM/ht2) or body mass index (ALM/BMI) to define low muscle mass. However, muscle function declines with aging before the loss of muscle mass is detected by ALM. This is likely due, in par...... hiện toàn bộ