Combination of DXA and BIS Predicts Jump Power Better Than Traditional Measures of Sarcopenia

JBMR Plus - Tập 5 Số 8 - 2021
Benjamin Rush1, Neil Binkley2, Diane Krueger2, Yosuke Yamada3, Adam J. Kuchnia1
1Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA.
2University of Wisconsin Osteoporosis Clinical Research Program, Madison, WI, USA
3Department of Physical Activity, National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan

Tóm tắt

ABSTRACTTraditional diagnostic criteria for sarcopenia use dual‐energy X‐ray absorptiometry (DXA)‐measured appendicular lean mass (ALM), normalized to height (ALM/ht2) or body mass index (ALM/BMI) to define low muscle mass. However, muscle function declines with aging before the loss of muscle mass is detected by ALM. This is likely due, in part, to qualitative muscle changes such as extracellular and intracellular fluid compartment shifts uncaptured by DXA. We propose combining bioimpedance spectroscopy (BIS), which estimates extracellular and intracellular compartment volume, with DXA to more accurately predict muscle function. This combination may help incorporate muscle quality, thereby improving sarcopenia diagnosis. We cross‐sectionally analyzed data from 248 Black and White participants aged 25 to 75 years from the Midlife in the United States Refresher Cohort. We proposed two novel muscle measures: ALM corrected by the BIS‐derived whole‐body extracellular to intracellular fluid ratio (E/I) and leg lean mass (LLM) corrected by leg‐specific E/I, creating (ALM/(E/I)W) and (LLM/(E/I)L), respectively. We compared the associations of traditional muscle measures, ALM/(E/I)W, and LLM/(E/I)L, with grip strength and lower limb power using jumping mechanography. LLM/(E/I)L explained jump power best at R2 = 0.803 compared with ALM/(E/I)W (p < 0.0001) and all other measures. ALM/(E/I)W explained jump power second best (R2 = 0.759) but not significantly better than traditional muscle measures. No muscle measure performed better than covariates when predicting handgrip strength. LLM/(E/I)L outperformed ALM/ht2 and ALM/BMI when predicting jump power. We propose LLM/(E/I)L is a powerful and clinically relevant method that accounts for muscle quality. © 2021 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.

Từ khóa


Tài liệu tham khảo

10.1093/ageing/afy169

10.1046/j.1532-5415.2002.50216.x

10.1016/j.archger.2016.10.013

10.1016/j.jamda.2017.04.005

World Health Organization, 2015, World report on ageing and health

10.1007/s00198-015-3236-5

10.1038/ejcn.2016.73

10.1007/s12603-018-1058-9

10.1093/gerona/glu010

10.1152/ajpendo.1996.271.6.E941

Yamada Y, 2017, Electrical properties assessed by bioelectrical impedance spectroscopy as biomarkers of age‐related loss of skeletal muscle quantity and quality, J Gerontol A Biol Sci Med Sci., 72, 1180

10.1088/0967-3334/27/9/012

10.1093/gerona/glq001

10.1016/j.jocd.2014.04.016

10.1093/gerona/61.10.1059

10.1007/s11657-018-0508-7

10.1186/s12891-016-1378-z

10.1016/j.jcrc.2015.05.024

Siglinsky E, 2015, Effect of age and sex on jumping mechanography and other measures of muscle mass and function, J Musculoskelet Neuronal Interact., 15, 301

10.1007/s00198-014-2983-z

10.1016/j.jocd.2015.04.010

10.1111/j.1532-5415.1994.tb06218.x

10.1002/jcsm.12411

RyffC AlmeidaDM AyanianJ et al.Midlife in the United States (MIDUS 2) 2004–2006.Inter‐university Consortium for Political and Social Research [distributor];2017. DOI:https://doi.org/10.3886/ICPSR04652.v7.

10.1093/ptj/67.9.1342

10.1016/S0363-5023(84)80146-X

10.3928/19404921-20161209-03

10.1152/jappl.1994.77.1.98

Lunneborg CE, 1994, Modeling experimental and observational data

10.1016/0375-6742(89)90071-X

10.1037/0033-2909.87.2.245

10.1136/bmj.310.6973.170

10.3758/BRM.41.4.1149

10.1093/aje/kwv153

10.1186/s13054-016-1563-3

10.1177/0884533616676264

Strasser E‐M, 2018, Strength training increases skeletal muscle quality but not muscle mass in old institutionalized adults: a randomized, multi‐arm parallel and controlled intervention study, Eur J Phys Rehabil Med., 54, 921

10.1007/s11357-014-9642-3

10.1002/ajhb.20956

10.1002/clc.4960130809

10.1007/s004210050316

10.1016/j.rmed.2004.03.003

10.1016/j.exger.2016.03.007

10.1016/j.bbr.2014.02.027

10.1016/j.exger.2013.04.003

10.1007/s00198-018-4475-z

10.1093/gerona/61.1.72

10.1016/j.biopha.2011.11.001

10.1186/s13054-016-1563-3

10.2215/CJN.10261013

Thông tin
Thông tin xuất bản

JBMR Plus

Tập 5 Số 8

Thông tin tác giả