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Association of Depression With All-Cause and Cardiovascular Disease Mortality Among Adults in China
JAMA network open - Tập 3 Số 2 - Trang e1921043
Ruiwei Meng, Canqing Yu, Na Liu, Meian He, Jun Lv, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Xiaomin Zhang, Zhengming Chen, Tangchun Wu, An Pan, Liming Li
Association of Depressive Symptoms With Incident Cardiovascular Diseases in Middle-Aged and Older Chinese Adults
JAMA network open - Tập 2 Số 12 - Trang e1916591
Haibin Li, Deqiang Zheng, Zhiwei Li, Zhiyuan Wu, Wei Feng, Xue Cao, Jiaxin Wang, Qi Gao, Xia Li, Wei Wang, Brian J. Hall, Yu‐Tao Xiang, Xiuhua Guo
Effect of Internet-Based Cognitive Behavioral Humanistic and Interpersonal Training vs Internet-Based General Health Education on Adolescent Depression in Primary Care
JAMA network open - Tập 1 Số 7 - Trang e184278
Tracy R. G. Gladstone, Daniela A. Terrizzi, Allison Paulson, Jennifer Nidetz, Jason Canel, Eumene Ching, Anita D. Berry, James Cantorna, Joshua Fogel, Milton Eder, Megan Bolotin, Lauren O. Thomann, Kathy Griffiths, Patrick Ip, David Aaby, C. Hendricks Brown, William R. Beardslee, Carl C. Bell, Theodore J. Crawford, Marian L. Fitzgibbon, Linda Schiffer, Nina Liu, Monika Marko-Holguin, Benjamin W. Van Voorhees
Patterns in Outpatient Benzodiazepine Prescribing in the United States
JAMA network open - Tập 2 Số 1 - Trang e187399
Sumit Agarwal, Bruce E. Landon
Association of Low Baseline Diaphragm Muscle Mass With Prolonged Mechanical Ventilation and Mortality Among Critically Ill Adults
JAMA network open - Tập 3 Số 2 - Trang e1921520
Michael C. Sklar, Martin Dres, Eddy Fan, Gordon D. Rubenfeld, Damon C. Scales, Margaret S. Herridge, Nuttapol Rittayamai, Michael O. Harhay, W. Darlene Reid, George Tomlinson, Dmitry Rozenberg, William McClelland, Stephen Riegler, A. S. Slutsky, Laurent Brochard, Niall D. Ferguson, Ewan C. Goligher
Association of Physical Activity and Fracture Risk Among Postmenopausal Women
JAMA network open - Tập 2 Số 10 - Trang e1914084
Michael J. LaMonte, Jean Wactawski‐Wende, Joseph C. Larson, Xiaodan Mai, John A. Robbins, Meryl S. LeBoff, Zhao Chen, Rebecca D. Jackson, Andrea Z. LaCroix, Judith K. Ockene, Kathleen M. Hovey, Jane A. Cauley
Evaluation of Combined Artificial Intelligence and Radiologist Assessment to Interpret Screening Mammograms
JAMA network open - Tập 3 Số 3 - Trang e200265
Thomas Schaffter, Diana S. M. Buist, Christoph I. Lee, Yaroslav Nikulin, Dezső Ribli, Yuanfang Guan, William Lotter, Zequn Jie, Hao Du, Sijia Wang, Jiashi Feng, Mengling Feng, Hyo-Eun Kim, F. Albiol, Alberto Albiol, Stephen Morrell, Zbigniew Wojna, Mehmet Eren Ahsen, Umar Asif, Antonio Jimeno Yepes, Shivanthan A.C. Yohanandan, Simona Rabinovici‐Cohen, Darvin Yi, Bruce Hoff, Thomas Yu, Elias Chaibub Neto, Daniel L. Rubin, Peter Lindholm, Laurie R. Margolies, Russell B. McBride, Joseph H. Rothstein, Weiva Sieh, Rami Ben‐Ari, Stefan Harrer, Andrew D. Trister, Stephen Friend, Thea Norman, Berkman Sahiner, Fredrik Strand, Justin Guinney, Gustavo Stolovitzky, Lester Mackey, Joyce Cahoon, Li Shen, Jae Ho Sohn, Hari Trivedi, Yiqiu Shen, Ljubomir Buturović, José Costa Pereira, Jaime S. Cardoso, Eduardo Castro, Karl Trygve Kalleberg, Obioma Pelka, Imane Nedjar, Krzysztof J. Geras, Felix Nensa, Ethan Goan, Sven Koitka, L. Caballero, David Cox, Pavitra Krishnaswamy, Gaurav Pandey, Christoph M. Friedrich, Dimitri Perrin, Clinton Fookes, Bibo Shi, Gerard Cardoso Negrie, Michael Kawczynski, Kyunghyun Cho, Can Son Khoo, Joseph Y. Lo, A. Gregory Sorensen, Hwejin Jung
Effect of Electroacupuncture vs Sham Treatment on Change in Pain Severity Among Adults With Chronic Low Back Pain
JAMA network open - Tập 3 Số 10 - Trang e2022787
Jiang‐Ti Kong, Chelcie Puetz, Lü Tian, Isaac Haynes, Eun‐Young Lee, Randall S. Stafford, Rachel Manber, Sean Mackey
Response to Biologic Drugs in Patients With Rheumatoid Arthritis and Antidrug Antibodies
JAMA network open - Tập 6 Số 7 - Trang e2323098
Samuel Bitoun, Signe Hässler, David Ternant, Natacha Szely, Aude Gleizes, Christophe Richez, Martin Soubrier, Jérôme Avouac, Olivier Brocq, Jérémie Sellam, Niek de Vries, T. Huizinga, Elizabeth C. Jury, Jessica Manson, Claudia Mauri, Andrea Matucci, Salima Hacein Bey Abina, Denis Mulleman, Marc Pallardy, Philippe Broët, Xavier Mariette, Françis Berenbaum, Philippe Dieudé, Philippe Bertin, Maxime Dougados, Corinne Miceli‐Richard, Aleth Pedriger, Hubert Marotte, A. Cantagrel, Olivier Vittecoq, Thierry Lequere, Alain Saraux, René-Marc Flipo, Jean Sibilia, Jacques Eric Gottenberg, B. Combe, Jacques Morel, Daniel Wendling, Carin Verhoef, M van Rijswijk, Michael T. Nurmohamed, Alessandra Vultaggio
ImportanceThere are conflicting data on the association of antidrug antibodies with response to biologic disease–modifying antirheumatic drugs (bDMARDs) in rheumatoid arthritis (RA).ObjectiveTo analyze the association of antidrug antibodies with response to treatment for RA.Design, Setting, and ParticipantsThis cohort study analyzed data from the ABI-RA (Anti-Biopharmaceutical Immunization: Prediction and Analysis of Clinical Relevance to Minimize the Risk of Immunization in Rheumatoid Arthritis Patients) multicentric, open, prospective study of patients with RA from 27 recruiting centers in 4 European countries (France, Italy, the Netherlands, and the UK). Eligible patients were 18 years or older, had RA diagnosis, and were initiating a new bDMARD. Recruitment spanned from March 3, 2014, to June 21, 2016. The study was completed in June 2018, and data were analyzed in June 2022.ExposuresPatients were treated with a new bDMARD: adalimumab, infliximab (grouped as anti–tumor necrosis factor [TNF] monoclonal antibodies [mAbs]), etanercept, tocilizumab, and rituximab according to the choice of the treating physician.Main Outcomes and MeasuresThe primary outcome was the association of antidrug antibody positivity with EULAR (European Alliance of Associations for Rheumatology; formerly, European League Against Rheumatism) response to treatment at month 12 assessed through univariate logistic regression. The secondary end points were the EULAR response at month 6 and at visits from month 6 to months 15 to 18 using generalized estimating equation models. Detection of antidrug antibody serum levels was performed at months 1, 3, 6, 12, and 15 to 18 using electrochemiluminescence (Meso Scale Discovery) and drug concentration for anti-TNF mAbs, and etanercept in the serum was measured using enzyme-linked immunosorbent assay.ResultsOf the 254 patients recruited, 230 (mean [SD] age, 54.3 [13.7] years; 177 females [77.0%]) were analyzed. At month 12, antidrug antibody positivity was 38.2% in patients who were treated with anti-TNF mAbs, 6.1% with etanercept, 50.0% with rituximab, and 20.0% with tocilizumab. There was an inverse association between antidrug antibody positivity (odds ratio [OR], 0.19; 95% CI, 0.09-0.38; P < .001) directed against all biologic drugs and EULAR response at month 12. Analyzing all the visits starting at month 6 using generalized estimating equation models confirmed the inverse association between antidrug antibody positivity and EULAR response (OR, 0.35; 95% CI, 0.18-0.65; P < .001). A similar association was found for tocilizumab alone (OR, 0.18; 95% CI, 0.04-0.83; P = .03). In the multivariable analysis, antidrug antibodies, body mass index, and rheumatoid factor were independently inversely associated with response to treatment. There was a significantly higher drug concentration of anti-TNF mAbs in patients with antidrug antibody–negative vs antidrug antibody–positive status (mean difference, −9.6 [95% CI, −12.4 to −6.9] mg/L; P < 001). Drug concentrations of etanercept (mean difference, 0.70 [95% CI, 0.2-1.2] mg/L; P = .005) and adalimumab (mean difference, 1.8 [95% CI, 0.4-3.2] mg/L; P = .01) were lower in nonresponders vs responders. Methotrexate comedication at baseline was inversely associated with antidrug antibodies (OR, 0.50; 95% CI, 0.25-1.00; P = .05).Conclusions and RelevanceResults of this prospective cohort study suggest an association between antidrug antibodies and nonresponse to bDMARDs in patients with RA. Monitoring antidrug antibodies could be considered in the treatment of these patients, particularly nonresponders to biologic RA drugs.
Evaluation of Factors Associated With Unmet Needs in Adult Cancer Survivors in Canada
JAMA network open - Tập 3 Số 3 - Trang e200506
Saad Shakeel, Jasmine Tung, Rami Rahal, Christian Finley
Tổng số: 83   
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