Association of Histologic Disease Activity With Progression of Nonalcoholic Fatty Liver Disease

JAMA network open - Tập 2 Số 10 - Trang e1912565
David E. Kleiner1, Elizabeth M. Brunt2, Laura Wilson3, Cynthia Behling4, Cynthia D. Guy5, Melissa J. Contos6, Oscar W. Cummings7, Matthew M. Yeh8, Ryan M. Gill9, Naga Chalasani10, Brent A. Neuschwander‐Tetri11, Anna Mae Diehl12, Srinivasan Dasarathy13, Norah A. Terrault14, Kris V. Kowdley15, Rohit Loomba16, Patricia Belt3, James Tonascia17,3, Joel E. Lavine18, Arun J. Sanyal19
1Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
2Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, Missouri
3Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland
4Department of Pathology, University of California San Diego School of Medicine, San Diego
5Department of Pathology, Duke University, Durham, North Carolina
6Department of Pathology, Virginia Commonwealth University School of Medicine, Richmond
7Department of Pathology, Indiana University School of Medicine, Indianapolis
8Department of Pathology, University of Washington, Seattle
9Department of Pathology, University of California San Francisco School of Medicine, San Francisco
10Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis
11Division of Gastroenterology, Saint Louis University School of Medicine, St Louis, Missouri
12Department of Gastroenterology, Duke University, Durham, North Carolina
13Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio
14Division of Gastroenterology and Liver, University of Southern California, Los Angeles
15Liver Care Network and Organ Care Research, Swedish Medical Center, Seattle, Washington
16Division of Gastroenterology, University of California San Diego School of Medicine, San Diego
17Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland
18Division of Pediatric Gastroenterology, Department of Pediatrics, Columbia University, New York, New York
19Division of Gastroenterology and Hepatology, Virginia Commonwealth University School of Medicine, Richmond

Tóm tắt

Từ khóa


Tài liệu tham khảo

Chalasani, 2018, The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases., Hepatology, 67, 328, 10.1002/hep.29367

Ekstedt, 2006, Long-term follow-up of patients with NAFLD and elevated liver enzymes., Hepatology, 44, 865, 10.1002/(ISSN)1527-3350

Hagström, 2017, Fibrosis stage but not NASH predicts mortality and time to development of severe liver disease in biopsy-proven NAFLD., J Hepatol, 67, 1265, 10.1016/j.jhep.2017.07.027

Adams, 2005, The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies., J Hepatol, 42, 132, 10.1016/j.jhep.2004.09.012

McPherson, 2015, Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: implications for prognosis and clinical management., J Hepatol, 62, 1148, 10.1016/j.jhep.2014.11.034

Pais, 2013, A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liver., J Hepatol, 59, 550, 10.1016/j.jhep.2013.04.027

Adams, 2005, The natural history of nonalcoholic fatty liver disease: a population-based cohort study., Gastroenterology, 129, 113, 10.1053/j.gastro.2005.04.014

Sorrentino, 2010, Predicting fibrosis worsening in obese patients with NASH through parenchymal fibronectin, HOMA-IR, and hypertension., Am J Gastroenterol, 105, 336, 10.1038/ajg.2009.587

Singh, 2015, Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies., Clin Gastroenterol Hepatol, 13, 643, 10.1016/j.cgh.2014.04.014

Sanyal, 2015, Challenges and opportunities in drug and biomarker development for nonalcoholic steatohepatitis: findings and recommendations from an American Association for the Study of Liver Diseases-U.S., Hepatology, 61, 1392, 10.1002/hep.v61.4

Saunders, 1993, Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on early detection of persons with harmful alcohol consumption—II., Addiction, 88, 791, 10.1111/add.1993.88.issue-6

Kleiner, 2005, Design and validation of a histological scoring system for nonalcoholic fatty liver disease., Hepatology, 41, 1313, 10.1002/(ISSN)1527-3350

Sanyal, 2010, Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis., N Engl J Med, 362, 1675, 10.1056/NEJMoa0907929

Brunt, 2009, Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): a histologic marker of advanced NAFLD-Clinicopathologic correlations from the nonalcoholic steatohepatitis clinical research network., Hepatology, 49, 809, 10.1002/hep.22724

Siddiqui, 2018, Case definitions for inclusion and analysis of endpoints in clinical trials for nonalcoholic steatohepatitis through the lens of regulatory science., Hepatology, 67, 2001, 10.1002/hep.v67.5

Kleiner, 2012, Nonalcoholic fatty liver disease: pathologic patterns and biopsy evaluation in clinical research., Semin Liver Dis, 32, 3, 10.1055/s-0032-1306421

Akaike, 1974, A new look at the statistical model identification., Transactions of Automatic Control, 19, 716, 10.1109/TAC.1974.1100705

Wang, 2000, Model selection using the Akaike information criterion., Stata Tech Bull, 54, 57

Brunt, 2019, Improvements in histologic features and diagnosis associated with improvement in fibrosis in nonalcoholic steatohepatitis: results from the Nonalcoholic Steatohepatitis Clinical Research Network Treatment Trials., Hepatology, 70, 522, 10.1002/hep.30418

Vilar-Gomez, 2015, Weight loss through lifestyle modification significantly reduces features of nonalcoholic steatohepatitis., Gastroenterology, 149, 367, 10.1053/j.gastro.2015.04.005

Powell, 1990, The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years., Hepatology, 11, 74, 10.1002/(ISSN)1527-3350

Ekstedt, 2012, Low clinical relevance of the nonalcoholic fatty liver disease activity score (NAS) in predicting fibrosis progression., Scand J Gastroenterol, 47, 108, 10.3109/00365521.2011.634024

Angulo, 2015, Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease., Gastroenterology, 149, 389, 10.1053/j.gastro.2015.04.043

Ajmera, 2018, Among patients with nonalcoholic fatty liver disease, modest alcohol use is associated with less improvement in histologic steatosis and steatohepatitis., Clin Gastroenterol Hepatol, 16, 1511, 10.1016/j.cgh.2018.01.026

Thông tin
Thông tin xuất bản

JAMA network open

Tập 2 Số 10

e1912565

Thông tin tác giả