International Journal of Toxicology

SCOPUS (1982-2023)SCIE-ISI

  1091-5818

  1092-874X

  Mỹ

Cơ quản chủ quản:  SAGE Publications Inc.

Lĩnh vực:
Toxicology

Các bài báo tiêu biểu

Bioavailability and Risk Assessment of Orally Ingested Polycyclic Aromatic Hydrocarbons
Tập 23 Số 5 - Trang 301-333 - 2004
Aramandla Ramesh, Stormy A. Walker, Darryl B. Hood, Marı́a D. Guillén, Klaus Schneider, Eric H. Weyand
Polycyclic aromatic hydrocarbons (PAHs) are a family of toxicants that are ubiquitous in the environment. These contaminants generate considerable interest, because some of them are highly carcinogenic in laboratory animals and have been implicated in breast, lung, and colon cancers in humans. These chemicals commonly enter the human body through inhalation of cigarette smoke or consumptio...... hiện toàn bộ
Gender-Based Differences in the Toxicity of Pharmaceuticals—The Food and Drug Administration's Perspective
Tập 20 Số 3 - Trang 149-152 - 2001
Margaret A. Miller
Women experience more adverse reactions to treatment with therapeutic drugs than men. Theories proposed to explain this include overdosing, different pharmacokinetics and pharmacodynamics, women are more likely to report adverse events than men, or women take more medications than men. Food and Drug Administration (FDA) Office of Women's Health (OWH) funds research to promote including wo...... hiện toàn bộ
Dynamic Effect of Di-2-(Ethylhexyl) Phthalate on Testicular Toxicity: Epigenetic Changes and Their Impact on Gene Expression
Tập 29 Số 2 - Trang 193-200 - 2010
Shengde Wu, Jing Zhu, Yasha Li, Tao Lin, Liqiang Gan, Xingang Yuan, Mingdeng Xu, Guanghui Wei
This study investigated epigenetic (specifically, DNA methylation) changes and their impact on gene expression in testes induced by maternal exposure to Di-2-(ethylhexyl) phthalate (DEHP) in mice. Testicular dysgenesis syndrome was induced in fetuses and pups by maternal exposure to DEHP at 500 mg/kg/d, and testes were excised for analysis on gestation day (GD) 19 and postnatal days (PNDs...... hiện toàn bộ
The Critical Role of House Dust in Understanding the Hazards Posed by Contaminated Soils
Tập 16 Số 4-5 - Trang 339-362 - 1997
Dennis J. Paustenbach, Brent L. Finley, Thomas F. Long
The health risks posed by soil pollutants are generally thought to be due to soilingestion and have often resulted in massive regulatory efforts to remedy such contamination. The contribution of this route to the actual human health hazard has been questioned, however, as soil removal alone seems to have little influence on the body burdens of soil contaminants in exposed individuals. Ong...... hiện toàn bộ
Safety Assessment of Triethanolamine and Triethanolamine-Containing Ingredients as Used in Cosmetics
Tập 32 Số 3_suppl - Trang 59S-83S - 2013
Monice Fiume, Bart Heldreth, Wilma F. Bergfeld, D. Belsito, Ronald A. Hill, Curtis D. Klaassen, D.C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen
The Cosmetic Ingredient Review Expert Panel assessed the safety of triethanolamine (TEA) and 31 related TEA-containing ingredients as used in cosmetics. The TEA is reported to function as a surfactant or pH adjuster; the related TEA-containing ingredients included in this safety assessment are reported to function as surfactants and hair- or skin-conditioning agents. The exception is TEA-...... hiện toàn bộ
Oxidative Stress as a Mechanism Involved in Kidney Damage After Subchronic Exposure to Vanadium Inhalation and Oral Sweetened Beverages in a Mouse Model
Tập 37 Số 1 - Trang 45-52 - 2018
Maribel Espinosa-Zurutuza, Adriana González-Villalva, Juan Carlos Albarrán-Alonso, Laura Colín‐Barenque, Patrícia Bizarro-Nevares, Marcela Rojas‐Lemus, Nelly López-Valdéz, Teresa I. Fortoul van der Goes
Kidney diseases have notably increased in the last few years. This is partially explained by the increase in metabolic syndrome, diabetes, and systemic blood hypertension. However, there is a segment of the population that has neither of the previous risk factors, yet suffers kidney damage. Exposure to atmospheric pollutants has been suggested as a possible risk factor. Air-suspended part...... hiện toàn bộ
Endotoxin Potentiates Cocaine-Mediated Hepatotoxicity by Nitric Oxide and Reactive Oxygen Species
Tập 22 Số 4 - Trang 305-316 - 2003
Ramez Labib, Rita M. Turkall, Mohamed S. Abdel‐Rahman
Exposure to small, noninjurious doses of the inflammagen, bacterial endotoxin (lipopolysaccharide, LPS) augments the toxicity of certain hepatotoxicants, including cocaine. The mechanism of this interaction has not been clearly elucidated, but it seems that aspects of the inflammatory response initiated by exposure to LPS may be responsible. In particular, this study examined the role of ...... hiện toàn bộ
Corticosteroid Production in H295R Cells During Exposure to 3 Endocrine Disrupters Analyzed With LC-MS/MS
Tập 32 Số 3 - Trang 219-227 - 2013
Christina S. Winther, Frederik Nielsen, Martin Hansen, Bjarne Styrishave
The adrenocortical human cell line H295R is a valuable tool for screening endocrine disrupting compounds. In general, previous research focus has been on the production of the 2 sex steroids, 17β-estradiol and testosterone, and less attention has been paid to other important steroid end points in the steroidogenesis with a wide range of physiological functions, such as the glucocorticoids...... hiện toàn bộ
14-Day Repeat-Dose Oral Toxicity Evaluation of Oxazyme in Rats and Dogs
Tập 29 Số 1 - Trang 20-31 - 2010
Aaron B. Cowley, Duane W. Poage, Robin R. Dean, Carol Meschter, Majid Ghoddusi, Qingshan Li, Harmeet Sidhu
Oxazyme (OC4) is an orally administered formulation that has as an active component a recombinant mutant form of Bacillus subtilis oxalate decarboxylase (OxDC) enzyme C383S, designed to degrade dietary oxalate in the stomach. Fourteen-day repeat-dose studies were conducted in rats and dogs to evaluate toxicity and determine a no observed adverse effect level (NOAEL). Animals were administ...... hiện toàn bộ
Safety Assessment of Diethanolamine and Its Salts as Used in Cosmetics
Tập 36 Số 5_suppl2 - Trang 89S-110S - 2017
Monice Fiume, Bart Heldreth, Wilma F. Bergfeld, D. Belsito, Ronald A. Hill, Curtis D. Klaassen, D.C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen
The Cosmetic Ingredient Review (CIR) Expert Panel assessed the safety of diethanolamine and its salts as used in cosmetics. Diethanolamine functions as a pH adjuster; the 16 salts included in this rereview reportedly function as surfactants, emulsifying agents, viscosity increasing agents, hair or skin conditioning agents, foam boosters, or antistatic agents. The Panel reviewed available ...... hiện toàn bộ