International Journal of Toxicology
SCOPUS (1982-2025)SCIE-ISI
1091-5818
1092-874X
Mỹ
Cơ quản chủ quản: SAGE Publications Inc.
Lĩnh vực:
Toxicology
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Bioavailability and Risk Assessment of Orally Ingested Polycyclic Aromatic Hydrocarbons
Tập 23 Số 5 - Trang 301-333 - 2004
Polycyclic aromatic hydrocarbons (PAHs) are a family of toxicants that are
ubiquitous in the environment. These contaminants generate considerable
interest, because some of them are highly carcinogenic in laboratory animals and
have been implicated in breast, lung, and colon cancers in humans. These
chemicals commonly enter the human body through inhalation of cigarette smoke or
consumption of con...
Gender-Based Differences in the Toxicity of Pharmaceuticals—The Food and Drug Administration's Perspective
Tập 20 Số 3 - Trang 149-152 - 2001
Women experience more adverse reactions to treatment with therapeutic drugs than
men. Theories proposed to explain this include overdosing, different
pharmacokinetics and pharmacodynamics, women are more likely to report adverse
events than men, or women take more medications than men. Food and Drug
Administration (FDA) Office of Women's Health (OWH) funds research to promote
including women in cl...
Dynamic Effect of Di-2-(Ethylhexyl) Phthalate on Testicular Toxicity: Epigenetic Changes and Their Impact on Gene Expression
Tập 29 Số 2 - Trang 193-200 - 2010
This study investigated epigenetic (specifically, DNA methylation) changes and
their impact on gene expression in testes induced by maternal exposure to
Di-2-(ethylhexyl) phthalate (DEHP) in mice. Testicular dysgenesis syndrome was
induced in fetuses and pups by maternal exposure to DEHP at 500 mg/kg/d, and
testes were excised for analysis on gestation day (GD) 19 and postnatal days
(PNDs) 3, 21, ...
The Critical Role of House Dust in Understanding the Hazards Posed by Contaminated Soils
Tập 16 Số 4-5 - Trang 339-362 - 1997
The health risks posed by soil pollutants are generally thought to be due to
soilingestion and have often resulted in massive regulatory efforts to remedy
such contamination. The contribution of this route to the actual human health
hazard has been questioned, however, as soil removal alone seems to have little
influence on the body burdens of soil contaminants in exposed individuals.
Ongoing rese...
Safety Assessment of Triethanolamine and Triethanolamine-Containing Ingredients as Used in Cosmetics
Tập 32 Số 3_suppl - Trang 59S-83S - 2013
The Cosmetic Ingredient Review Expert Panel assessed the safety of
triethanolamine (TEA) and 31 related TEA-containing ingredients as used in
cosmetics. The TEA is reported to function as a surfactant or pH adjuster; the
related TEA-containing ingredients included in this safety assessment are
reported to function as surfactants and hair- or skin-conditioning agents. The
exception is TEA-sorbate, ...
Endotoxin Potentiates Cocaine-Mediated Hepatotoxicity by Nitric Oxide and Reactive Oxygen Species
Tập 22 Số 4 - Trang 305-316 - 2003
Exposure to small, noninjurious doses of the inflammagen, bacterial endotoxin
(lipopolysaccharide, LPS) augments the toxicity of certain hepatotoxicants,
including cocaine. The mechanism of this interaction has not been clearly
elucidated, but it seems that aspects of the inflammatory response initiated by
exposure to LPS may be responsible. In particular, this study examined the role
of Kupffer c...
Oxidative Stress as a Mechanism Involved in Kidney Damage After Subchronic Exposure to Vanadium Inhalation and Oral Sweetened Beverages in a Mouse Model
Tập 37 Số 1 - Trang 45-52 - 2018
Kidney diseases have notably increased in the last few years. This is partially
explained by the increase in metabolic syndrome, diabetes, and systemic blood
hypertension. However, there is a segment of the population that has neither of
the previous risk factors, yet suffers kidney damage. Exposure to atmospheric
pollutants has been suggested as a possible risk factor. Air-suspended particles
car...
Corticosteroid Production in H295R Cells During Exposure to 3 Endocrine Disrupters Analyzed With LC-MS/MS
Tập 32 Số 3 - Trang 219-227 - 2013
The adrenocortical human cell line H295R is a valuable tool for screening
endocrine disrupting compounds. In general, previous research focus has been on
the production of the 2 sex steroids, 17β-estradiol and testosterone, and less
attention has been paid to other important steroid end points in the
steroidogenesis with a wide range of physiological functions, such as the
glucocorticoids (cortico...
14-Day Repeat-Dose Oral Toxicity Evaluation of Oxazyme in Rats and Dogs
Tập 29 Số 1 - Trang 20-31 - 2010
Oxazyme (OC4) is an orally administered formulation that has as an active
component a recombinant mutant form of Bacillus subtilis oxalate decarboxylase
(OxDC) enzyme C383S, designed to degrade dietary oxalate in the stomach.
Fourteen-day repeat-dose studies were conducted in rats and dogs to evaluate
toxicity and determine a no observed adverse effect level (NOAEL). Animals were
administered OC4 ...
Safety Assessment of Diethanolamine and Its Salts as Used in Cosmetics
Tập 36 Số 5_suppl2 - Trang 89S-110S - 2017
The Cosmetic Ingredient Review (CIR) Expert Panel assessed the safety of
diethanolamine and its salts as used in cosmetics. Diethanolamine functions as a
pH adjuster; the 16 salts included in this rereview reportedly function as
surfactants, emulsifying agents, viscosity increasing agents, hair or skin
conditioning agents, foam boosters, or antistatic agents. The Panel reviewed
available animal an...