International Journal of Toxicology
SCOPUS (1982-2023)SCIE-ISI
1091-5818
1092-874X
Mỹ
Cơ quản chủ quản: SAGE Publications Inc.
Lĩnh vực:
Toxicology
Các bài báo tiêu biểu
Bioavailability and Risk Assessment of Orally Ingested Polycyclic Aromatic HydrocarbonsPolycyclic aromatic hydrocarbons (PAHs) are a family of toxicants that are ubiquitous in the environment. These contaminants generate considerable interest, because some of them are highly carcinogenic in laboratory animals and have been implicated in breast, lung, and colon cancers in humans. These chemicals commonly enter the human body through inhalation of cigarette smoke or consumptio... ...
Tập 23 Số 5 - Trang 301-333 - 2004
Gender-Based Differences in the Toxicity of Pharmaceuticals—The Food and Drug Administration's Perspective Women experience more adverse reactions to treatment with therapeutic drugs than men. Theories proposed to explain this include overdosing, different pharmacokinetics and pharmacodynamics, women are more likely to report adverse events than men, or women take more medications than men. Food and Drug Administration (FDA) Office of Women's Health (OWH) funds research to promote including wo... ...
Tập 20 Số 3 - Trang 149-152 - 2001
Dynamic Effect of Di-2-(Ethylhexyl) Phthalate on Testicular Toxicity: Epigenetic Changes and Their Impact on Gene Expression This study investigated epigenetic (specifically, DNA methylation) changes and their impact on gene expression in testes induced by maternal exposure to Di-2-(ethylhexyl) phthalate (DEHP) in mice. Testicular dysgenesis syndrome was induced in fetuses and pups by maternal exposure to DEHP at 500 mg/kg/d, and testes were excised for analysis on gestation day (GD) 19 and postnatal days (PNDs... ...
Tập 29 Số 2 - Trang 193-200 - 2010
The Critical Role of House Dust in Understanding the Hazards Posed by Contaminated Soils The health risks posed by soil pollutants are generally thought to be due to soilingestion and have often resulted in massive regulatory efforts to remedy such contamination. The contribution of this route to the actual human health hazard has been questioned, however, as soil removal alone seems to have little influence on the body burdens of soil contaminants in exposed individuals. Ong... ...
Tập 16 Số 4-5 - Trang 339-362 - 1997
Safety Assessment of Triethanolamine and Triethanolamine-Containing Ingredients as Used in Cosmetics The Cosmetic Ingredient Review Expert Panel assessed the safety of triethanolamine (TEA) and 31 related TEA-containing ingredients as used in cosmetics. The TEA is reported to function as a surfactant or pH adjuster; the related TEA-containing ingredients included in this safety assessment are reported to function as surfactants and hair- or skin-conditioning agents. The exception is TEA-... ...
Tập 32 Số 3_suppl - Trang 59S-83S - 2013
Endotoxin Potentiates Cocaine-Mediated Hepatotoxicity by Nitric Oxide and Reactive Oxygen Species Exposure to small, noninjurious doses of the inflammagen, bacterial endotoxin (lipopolysaccharide, LPS) augments the toxicity of certain hepatotoxicants, including cocaine. The mechanism of this interaction has not been clearly elucidated, but it seems that aspects of the inflammatory response initiated by exposure to LPS may be responsible. In particular, this study examined the role of ... ...
Tập 22 Số 4 - Trang 305-316 - 2003
Oxidative Stress as a Mechanism Involved in Kidney Damage After Subchronic Exposure to Vanadium Inhalation and Oral Sweetened Beverages in a Mouse Model Kidney diseases have notably increased in the last few years. This is partially explained by the increase in metabolic syndrome, diabetes, and systemic blood hypertension. However, there is a segment of the population that has neither of the previous risk factors, yet suffers kidney damage. Exposure to atmospheric pollutants has been suggested as a possible risk factor. Air-suspended part... ...
Tập 37 Số 1 - Trang 45-52 - 2018
14-Day Repeat-Dose Oral Toxicity Evaluation of Oxazyme in Rats and Dogs Oxazyme (OC4) is an orally administered formulation that has as an active component a recombinant mutant form of Bacillus subtilis oxalate decarboxylase (OxDC) enzyme C383S, designed to degrade dietary oxalate in the stomach. Fourteen-day repeat-dose studies were conducted in rats and dogs to evaluate toxicity and determine a no observed adverse effect level (NOAEL). Animals were administ... ...
Tập 29 Số 1 - Trang 20-31 - 2010
Corticosteroid Production in H295R Cells During Exposure to 3 Endocrine Disrupters Analyzed With LC-MS/MS The adrenocortical human cell line H295R is a valuable tool for screening endocrine disrupting compounds. In general, previous research focus has been on the production of the 2 sex steroids, 17β-estradiol and testosterone, and less attention has been paid to other important steroid end points in the steroidogenesis with a wide range of physiological functions, such as the glucocorticoids... ...
Tập 32 Số 3 - Trang 219-227 - 2013
Safety Assessment of Diethanolamine and Its Salts as Used in Cosmetics The Cosmetic Ingredient Review (CIR) Expert Panel assessed the safety of diethanolamine and its salts as used in cosmetics. Diethanolamine functions as a pH adjuster; the 16 salts included in this rereview reportedly function as surfactants, emulsifying agents, viscosity increasing agents, hair or skin conditioning agents, foam boosters, or antistatic agents. The Panel reviewed available ... ...
Tập 36 Số 5_suppl2 - Trang 89S-110S - 2017