International Journal of Clinical Oncology

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Management of elderly patients with head and neck carcinoma: analysis of outcomes for radical versus palliative treatment
International Journal of Clinical Oncology - Tập 25 - Trang 432-438 - 2019
Seiji Hosokawa, Goro Takahashi, Jun Okamura, Atsushi Imai, Daiki Mochizuki, Ryuji Ishikawa, Yoshinori Takizawa, Takashi Yamatodani, Kiyoshi Misawa, Hiroyuki Mineta
There are no universally accepted treatment recommendations for elderly patients with head and neck carcinomas. This study investigated whether radical treatment in elderly patients resulted in better survival compared with palliative treatment. We retrospectively reviewed the medical records of 724 patients aged > 60 years who underwent treatment for primary head and neck carcinomas at Hamamatsu ...... hiện toàn bộ
The rate of facial nerve dysfunction and time to recovery after intraparotid and extraparotid facial nerve exposure and protection in head and neck cutaneous tumor surgery
International Journal of Clinical Oncology - - 2017
Yasuhiro Nakamura, Yukiko Teramoto, Yuri Asami, Taichi Imamura, Sayuri Sato, Ryota Tanaka, Hiroshi Maruyama, Yoshiyuki Nakamura, Yasuhiro Fujisawa, Manabu Fujimoto, Akifumi Yamamoto
Expression of SMARCA2 and SMARCA4 in gastric adenocarcinoma and construction of a nomogram prognostic model
International Journal of Clinical Oncology - Tập 28 - Trang 1487-1500 - 2023
Zhenkun Zhang, Qiujing Li, Shanshan Sun, Zhe Li, ZhengGuo Cui, Qian Liu, Yujie Zhang, Sili Xiong, Shukun Zhang
Aberrant expression of SWI/SNF complex subunits is closely associated with tumorigenesis. The clinicopathological and prognostic significance of altered SMARCA2 and SMARCA4 subunits has not been well evaluated in gastric adenocarcinoma. We collected 1271 postoperative cases of gastric adenocarcinoma and then constructed tissue microarrays (TMA), from which we obtained the immunohistochemistry expr...... hiện toàn bộ
Muscle strength and functional recovery for soft-tissue sarcoma of the thigh: a prospective study
International Journal of Clinical Oncology - Tập 28 - Trang 922-927 - 2023
Atsushi Tanaka, Masanori Okamoto, Munehisa Kito, Yasuo Yoshimura, Kaoru Aoki, Shuichiro Suzuki, Akira Takazawa, Yukiko Komatsu, Hirokazu Ideta, Takaaki Ishida, Jun Takahashi
This study aimed to investigate changes in muscle strength and functional outcome before and after surgery for soft-tissue sarcoma of the thigh and to examine the timing of recovery. From 2014 to 2019, 15 patients who underwent multiple resections of the thigh muscle for soft-tissue sarcoma of the thigh were included in this study. The muscle strength was measured with an isokinetic dynamometer fo...... hiện toàn bộ
Retrospective study of results of interstitial radiotherapy for cancer of the tongue
International Journal of Clinical Oncology - - 1996
Junichi Hiratsuka, Tsuyoshi Hata, Masaru Hosoda, Mineo Yoshida, Kazunari Yamada, Yoshinari Imajo
This retrospective study was carried out to clarify whether interstitial radiotherapy is effective in the management of carcinoma of the tongue. The subjects were 65 previously untreated patients with invasive squamous cell carcinoma of the anterior two-thirds of the tongue who received mainly interstitial radiotherapy using137Cs needles with or without external irradiation between 1977 and 1993. ...... hiện toàn bộ
Evaluating the 21-gene assay Recurrence Score® as a predictor of clinical response to 24 weeks of neoadjuvant exemestane in estrogen receptor-positive breast cancer
International Journal of Clinical Oncology - Tập 19 - Trang 607-613 - 2013
Takayuki Ueno, Norikazu Masuda, Takeharu Yamanaka, Shigehira Saji, Katsumasa Kuroi, Nobuaki Sato, Hiroyuki Takei, Yutaka Yamamoto, Shinji Ohno, Hiroko Yamashita, Kazufumi Hisamatsu, Kenjiro Aogi, Hiroji Iwata, Hironobu Sasano, Masakazu Toi
The aim of this study was to investigate the association between the results of the Recurrence Score (RS) assay and the clinical response to neoadjuvant endocrine therapy in postmenopausal women with breast cancer. Core biopsy samples at baseline and post-treatment surgical samples were obtained from 80 and 77 of 116 patients, respectively, enrolled in the multicenter prospective study of neoadju...... hiện toàn bộ
Gemcitabine and paclitaxel chemotherapy for advanced urothelial carcinoma in patients who have received prior cisplatin-based chemotherapy
International Journal of Clinical Oncology - Tập 13 - Trang 510-514 - 2008
Kunimitsu Kanai, Eiji Kikuchi, Takashi Ohigashi, Akira Miyajima, Ken Nakagawa, Jun Nakashima, Mototsugu Oya
The objective of this study was to evaluate the efficacy and toxicity of combination chemotherapy with gemcitabine and paclitaxel as a second-line regimen in patients with advanced urothelial carcinoma. Twenty patients with advanced urothelial carcinoma who were resistant to an M-VAC (methotrexate, vinblastine, doxorubicin, and cisplatin) chemotherapy regimen were administered chemotherapy consist...... hiện toàn bộ
Comment on “Clinical effectiveness of surgical treatment after Lenvatinib administration for hepatocellular carcinoma”
International Journal of Clinical Oncology - Tập 28 - Trang 610-611 - 2023
Samar Sajid
Nivolumab in patients with unresectable locally advanced or metastatic urothelial carcinoma: CheckMate 275 2-year global and Japanese patient population analyses
International Journal of Clinical Oncology - Tập 24 - Trang 1089-1098 - 2019
Chikara Ohyama, Takahiro Kojima, Tsunenori Kondo, Yoshio Naya, Takamitsu Inoue, Yoshihiko Tomita, Masatoshi Eto, Shinichi Hisasue, Hirotsugu Uemura, Wataru Obara, Eiji Kikuchi, Padmanee Sharma, Matthew D. Galsky, Arlene Siefker-Radtke, Gary Grossfeld, Sandra Collette, Kyna Gooden, Go Kimura
Nivolumab has demonstrated antitumor activity and manageable safety in the single-arm, phase II CheckMate 275 study in patients with unresectable locally advanced or metastatic platinum-resistant urothelial carcinoma. We report updated results of the global population and a subanalysis of Japanese patients from this study. Patients received nivolumab 3 mg/kg intravenously every 2 weeks until progr...... hiện toàn bộ
Clinical features and distribution of the APC variant in duodenal and ampullary polyps in patients with familial adenomatous polyposis: a multicenter retrospective cohort study in Japan
International Journal of Clinical Oncology - - Trang 1-10 - 2023
Yasuyuki Miyakura, Tatsuro Yamaguchi, Alan Kawarai Lefor, Sawako Tamaki, Akinari Takao, Misato Takao, Yoshiko Mori, Kenichi Chikatani, Hideyuki Ishida, Mitsuhiro Kono, Yoji Takeuchi, Hideki Ishikawa, Toshiya Nagasaki, Kazuhito Sasaki, Takaaki Matsubara, Keiji Hirata, Fumitaka Taniguchi, Kohji Tanakaya, Naohiro Tomita, Yoichi Ajioka
Management of duodenal or ampullary adenomas in patients with familial adenomatous polyposis (FAP) is a major challenge for clinicians. Insufficient data are available to evaluate the clinical manifestations and distribution of adenomatous polyposis coli (APC) variants in these patients. We enrolled 451 patients with data regarding duodenal or ampullary polyps from 632 patients with FAP retrospect...... hiện toàn bộ
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