Comparison of survival outcomes between adolescent and young adults and older adults with tongue squamous cell carcinoma: a nationwide database study using the head and neck cancer registry of Japan
Tóm tắt
This study aimed to evaluate the prognostic outcome for adolescent and young adult (AYA) generation patients with tongue squamous cell carcinoma (TSCC). Data were obtained from the Head and Neck Cancer Registry of Japan, and patients who were newly diagnosed with TSCC from 2011 to 2014 were extracted. We compared the clinical parameter and survival of the ≤ 39 years old (AYA) patient group with the 40–79 (non-AYA) group. Propensity score matching (PSM) was used for survival analyses. Our cohort included 2221 patients with TSCC. AYA and non-AYA groups consisted of 258 and 1963 patients, respectively. The AYA group has a larger proportion of females than the non-AYA group (P < 0.001). Following PSM, both overall and disease-specific survival of the AYA group was significantly longer than those of the non-AYA group (P = 0.009 and P = 0.04, respectively). We demonstrated the survival superiority of AYA patients with TSCC compared to older adult patients. Therefore, our study results may reduce this anxiety by providing patients with appropriate information of prognosis for AYA patients with TSCC.
Tài liệu tham khảo
Omura K (2014) Current status of oral cancer treatment strategies: surgical treatment for oral squamous cell carcinoma. Int J Clin Oncol 19:423–430
The National Cancer Center Japan (JP) (2022) National cancer center-cancer information service. https://ganjoho.jp. Accessed 19 Apr 2022.
Japan Society for Head and Neck Cancer, Cancer Registry Committee (2022) Report of head and neck cancer registry of Japan clinical statistics of registered patients, 2019. http://www.jshnc.umin.ne.jp/pdf/HNCreport_2019.pdf. Accessed 4 Apr 2022.
Cancer and Disease Control Division, Ministry of Health, Labour and Welfare (2021) Cancer incidence of Japan 2019. https://www.mhlw.go.jp/content/10900000/000942181.pdf Accessed 2 Aug 2022.
Hirayama T, Kojima R, Udagawa R et al (2022) A questionnaire survey on adolescent and young adult hiroba, a peer support system for adolescent and young adult cancer patients at designated cancer center in Japan. J Adolesc Young Adult Oncol 11:309–315
Bleyer A, Barr R, Hayes-Lattin B et al (2008) The distinctive biology of cancer in adolescents and young adults. Nat Rev Cancer 8:288–298
Verschuur HP, Irish JC, O’Sullivan B et al (1999) A matched control study of treatment outcome in young patients with squamous cell carcinoma of the head and neck. Laryngoscope 109:249–258
Oliver JR, Wu SP, Chang CM et al (2019) Survival of oral tongue squamous cell carcinoma in young adults. Head Neck 41:2960–2968
Okuyama K, Yamamoto S, Michi Y et al (2021) Multicenter retrospective analysis of clinicopathological features and prognosis of oral tongue squamous cell carcinoma in adolescent and young adult patients. Medicine 100:41
Kanda Y (2013) Investigation of the freely-available easy-to-use software “EZR” (Easy R) for medical statistics. Bone Marrow Transplant 48:452–458
Kim Y, Okuyama K, Michi Y et al (2017) Potential factors influencing the development of oral tongue squamous cell carcinoma in young mature patients: lingual position of the mandibular second molar and narrow tongue space. Oncol Lett 14:7339–7343
Poeta ML, Manola J, Goldwasser MA et al (2007) TP53 mutations and survival in squamous-cell carcinoma of the head and neck. N Engl J Med 357:2552–2561
Sorensen DM, Lewark TM, Haney JL et al (1997) Absence of p53 mutations in squamous cell carcinomas of the tongue in nonsmoking and nondrinking patients younger than 40 years. Arch Otolaryngol Head Neck Surg 123:503–506
D’Cruz AK, Vaish R, Kapre N et al (2015) Elective versus therapeutic neck dissection in node-negative oral cancer. N Engl J Med 373:521–529
Suzuki M, Yoshino K, Fujii T et al (2014) Outcome of tongue cancer treated with surgery and postoperative radiotherapy. J Otorhinolaryng Soc Jpn 117:907–913 (Japanese)
Matsuura K, Hayashi R, Ebihara S et al (2004) Result of surgical treatment for squamous cell carcinoma of tongue. Toukeibugan 30:550–557 (Japanese)
Tanaka K, Hanai N, Eba J et al (2018) Randomized phase III study to evaluate the value of omission of prophylactic neck dissection for stage I/II tongue cancer: Japan clinical oncology group study (JCOG1601, respond). Jpn J Clin Oncol 48:1105–1108
Hirayama T, Fujimori M, Yanai Y et al (2022) Development and evaluation of the feasibility, validity, and reliability of a screening tool for determining distress and supportive care needs of adolescents and young adults with cancer in Japan. Palliat Support Care (in press). https://doi.org/10.1017/S147895152200092X
Okamura M, Fujimori M, Sato A et al (2021) Unmet supportive care needs and associated factors among young adult cancer patients in Japan. BMC Cancer 21:17