Growing teratoma syndrome of ovary

International Journal of Clinical Oncology - Tập 13 - Trang 83-87 - 2008
Roopa Hariprasad1, Lalit Kumar1, Deepa Janga2, Sunesh Kumar2, Malini Vijayaraghavan3
1Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India
2Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India
3Department of Pathology, All India Institute of Medical Sciences, New Delhi, India

Tóm tắt

Growing teratoma syndrome is an increase of tumor size containing only a mature teratoma component, during or after chemotherapy for germ cell tumors. Mature teratomatous elements are chemoresistant and have to be resected surgically. We describe three patients with malignant immature teratoma treated with chemotherapy and surgical resection. All three had an increase in the size of the mass after chemotherapy, surgery was possible, and histology revealed mature teratoma. One of the patients showed fluorodeoxy glucose positron emission tomography (FDG-PET) positivity for growing teratoma syndrome, but the histology revealed only mature teratoma. All three patients are alive, at 55, 72, and 103 months’ follow up after the initial diagnosis. Data collected from the literature are reviewed. Early recognition of this syndrome is essential as it offers hope for curative resection and avoids the use of ineffective chemotherapy.

Tài liệu tham khảo

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