Interdisciplinary Sciences: Computational Life Sciences
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A Novel Human Diabetes Biomarker Recognition Approach Using Fuzzy Rough Multigranulation Nearest Neighbour Classifier Model
Interdisciplinary Sciences: Computational Life Sciences - Tập 12 - Trang 461-475 - 2020
The selection of gene identifier from microarray databases is a challenging task since microarray contains large number of gene attributes for a few samples. This article proposes a novel fuzzy-rough set-based gene expression features selection using fuzzy-rough reduct under multi-granular space for human diabetes patient. Firstly, fuzzy multi-granular gain has been computed from the expression da......
Predicting Km values of beta-glucosidases using cellobiose as substrate
Interdisciplinary Sciences: Computational Life Sciences - Tập 4 - Trang 46-53 - 2012
The Michaelis-Menten constant Km is a very important parameter to relate enzyme with its substrate in enzymatic reaction. Although Km can be experimentally determined, the Km values are not easily available in literature. With rapid increase of newly designed enzymes, we face the shortage of parameters related to enzymatic reactions. The beta-glucosidase is a crucial enzyme for cellulose hydrolysi......
Differential Diagnosis of DCIS and Fibroadenoma Based on Ultrasound Images: a Difference-Based Self-Supervised Approach
Interdisciplinary Sciences: Computational Life Sciences - Tập 15 - Trang 262-272 - 2023
Differentiation of ductal carcinoma in situ (DCIS, a precancerous lesion of the breast) from fibroadenoma (FA) using ultrasonography is significant for the early prevention of malignant breast tumors. Radiomics-based artificial intelligence (AI) can provide additional diagnostic information but usually requires extensive labeling efforts by clinicians with specialized knowledge. This study aims to......
B-MIC: An Ultrafast Three-Level Parallel Sequence Aligner Using MIC
Interdisciplinary Sciences: Computational Life Sciences - - 2016
Analysis of CRISPR-Cas Loci and their Targets in Levilactobacillus brevis
Interdisciplinary Sciences: Computational Life Sciences - Tập 15 Số 3 - Trang 349-359 - 2023
Khảo sát gen mục tiêu in silico và mô hình so sánh tiết lộ một protein tiềm năng tương tự như yếu tố phiên mã liên kết DNA chịu hạn của Arabidopsis trong nhiễm sắc thể 6 của bộ gen Sorghum bicolor Dịch bởi AI
Interdisciplinary Sciences: Computational Life Sciences - Tập 4 - Trang 133-141 - 2012
Gen Arabidopsis Thaliana HARDY (AtHRD) là một gen có miền APETELA 2 / Yếu tố phản ứng Ethylene (AP2/ERF) liên quan đến khả năng hoạt động được cải thiện trong điều kiện hạn hán ở lúa. Chúng tôi đã giả định rằng bộ gen của cây sorgum có thể chứa một sản phẩm gen tương tự và đã thực hiện khai thác gen quy mô tính toán để tìm kiếm protein và phân tích các đặc tính cấu trúc và chức năng của nó. Chuỗi ......
#Arabidopsis Thaliana #Sorghum bicolor #APETELA 2 #Ethylene Responsive Factor #gen chịu hạn #khai thác gen #mô hình đồng homology #phân tích cấu trúc #phân tích chức năng
Genetic ancestor of external antigens of pandemic influenza A/H1N1 virus
Interdisciplinary Sciences: Computational Life Sciences - Tập 4 - Trang 282-290 - 2013
The aim of the present investigation was to discover the genetic relationships of 2009 pandemic novel influenza A/H1N1 virus (NIV) external antigens Hemagglutinin (HA) and Neuraminidase (NA) with other influenza viruses by performing phylogenetic, comparative and statistical analyses. Phylogenetic trees of these two antigens show that the sequences of the NIV viruses are relatively homogeneous and......
A peptide-linkage deletion procedure for estimate of energetic contributions of individual peptide groups in a complex environment: Application to parallel β-Sheets
Interdisciplinary Sciences: Computational Life Sciences - Tập 1 - Trang 12-20 - 2009
A peptide-linkage deletion procedure is introduced for extracting the quantum mechanical (QM) interaction energies of individual groups in a complex environment and applied for the determination of the energetic contributions of the individual hydrogen bond acceptors (C=O’s) and donors (N-H’s) in parallel β-sheets. For the β-sheets studied here, the results show that the contributions from the H-b......
In Silico Analysis of Conformational Changes Induced by Normal and Mutation of Macrophage Infectivity Potentiator Catalytic Residues and its Interactions with Rapamycin
Interdisciplinary Sciences: Computational Life Sciences - Tập 7 - Trang 326-333 - 2015
The Legionella pneumophila (Lp), human pathogen, causes severe and often fatal Legionnaires’ disease, produces a major virulence factor, termed ‘macrophage infectivity potentiator protein’ (Mip), that is necessary for optimal multiplication of the bacteria within human alveolar macrophages. Mip exhibits peptidyl prolyl cis–trans isomerase (PPIase) activity, which can be inhibited by rapamycin and ......
Investigating the Conformational Structure and Potential Site Interactions of SOD Inhibitors on Ec-SOD in Marine Mud Crab Scylla serrata: A Molecular Modeling Approach
Interdisciplinary Sciences: Computational Life Sciences - Tập 8 - Trang 312-318 - 2015
Superoxide dismutases (SODs) act as a first line of the enzymatic antioxidant defense system to control cellular superoxide anion toxicity. Previously, several inhibitors have been widely identified and catalogued for inhibition of SOD activity; however, still the information about the mechanism of interaction and points toward the inhibitor interactions in structures of SODs in general and in ext......
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