Application of Immune Checkpoint Inhibitors in Solid Organ Transplantation Recipients: A Systematic Review

citation_journal_title=Sci Transl Med; citation_title=Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation; citation_author=C McDonald-Hyman, LA Turka, BR Blazar; citation_volume=7; citation_issue=280; citation_publication_date=2015; citation_pages=280rv282; citation_doi=10.1126/scitranslmed.aaa6853; citation_id=CR1 citation_journal_title=Transplantation; citation_title=Practical recommendations for long-term management of modifiable risks in kidney and liver transplant recipients: a guidance report and clinical checklist by the consensus on managing modifiable risk in transplantation (COMMIT) group; citation_author=JM Neuberger, WO Bechstein, DR Kuypers, P Burra, F Citterio, S Geest, C Duvoux, AG Jardine, N Kamar, BK Krämer, HJ Metselaar, F Nevens, J Pirenne, ML Rodríguez-Perálvarez, D Samuel, S Schneeberger, D Serón, P Trunečka, G Tisone, T Gelder; citation_volume=101; citation_issue=4S Suppl2; citation_publication_date=2017; citation_pages=S1-s56; citation_doi=10.1097/tp.0000000000001651; citation_id=CR2 citation_journal_title=F1000Research; citation_title=Recent advances in lung transplantation; citation_author=KC Meyer; citation_publication_date=2018; citation_doi=10.12688/f1000research.15393.1; citation_id=CR3 citation_journal_title=Transfus Apher Sci Off J World Apher Assoc Off J Eur Soc Haemapheresis; citation_title=The mechanisms of rejection in solid organ transplantation; citation_author=E Cozzi, A Colpo, G Silvestro; citation_volume=56; citation_issue=4; citation_publication_date=2017; citation_pages=498-505; citation_doi=10.1016/j.transci.2017.07.005; citation_id=CR4 citation_journal_title=Surg Pathol Clin; citation_title=Acute, chronic, and humoral rejection: pathologic features under current immunosuppressive regimes; citation_author=J Koo, HL Wang; citation_volume=11; citation_issue=2; citation_publication_date=2018; citation_pages=431-452; citation_doi=10.1016/j.path.2018.02.011; citation_id=CR5 citation_journal_title=Lancet (London, England); citation_title=Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis; citation_author=AE Grulich, MT Leeuwen, MO Falster, CM Vajdic; citation_volume=370; citation_issue=9581; citation_publication_date=2007; citation_pages=59-67; citation_doi=10.1016/s0140-6736(07)61050-2; citation_id=CR6 citation_journal_title=Nat Rev Immunol; citation_title=Tumour-intrinsic resistance to immune checkpoint blockade; citation_author=A Kalbasi, A Ribas; citation_volume=20; citation_issue=1; citation_publication_date=2020; citation_pages=25-39; citation_doi=10.1038/s41577-019-0218-4; citation_id=CR7 citation_journal_title=Curr Med Chem; citation_title=Immune checkpoint inhibitors: basics and challenges; citation_author=B Li, HL Chan, P Chen; citation_volume=26; citation_issue=17; citation_publication_date=2019; citation_pages=3009-3025; citation_doi=10.2174/0929867324666170804143706; citation_id=CR8 citation_journal_title=N Engl J Med; citation_title=Improved survival with ipilimumab in patients with metastatic melanoma; citation_author=FS Hodi, SJ O'Day, DF McDermott, RW Weber, JA Sosman, JB Haanen, R Gonzalez, C Robert, D Schadendorf, JC Hassel, W Akerley, AJ Eertwegh, J Lutzky, P Lorigan, JM Vaubel, GP Linette, D Hogg, CH Ottensmeier, C Lebbé, C Peschel, I Quirt, JI Clark, JD Wolchok, JS Weber, J Tian, MJ Yellin, GM Nichol, A Hoos, WJ Urba; citation_volume=363; citation_issue=8; citation_publication_date=2010; citation_pages=711-723; citation_doi=10.1056/NEJMoa1003466; citation_id=CR9 citation_journal_title=Lancet (London, England); citation_title=Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial; citation_author=RS Herbst, P Baas, DW Kim, E Felip, JL Pérez-Gracia, JY Han, J Molina, JH Kim, CD Arvis, MJ Ahn, M Majem, MJ Fidler, G Castro, M Garrido, GM Lubiniecki, Y Shentu, E Im, M Dolled-Filhart, EB Garon; citation_volume=387; citation_issue=10027; citation_publication_date=2016; citation_pages=1540-1550; citation_doi=10.1016/s0140-6736(15)01281-7; citation_id=CR10 citation_journal_title=Lancet (London, England); citation_title=Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial; citation_author=JE Rosenberg, J Hoffman-Censits, T Powles, MS Heijden, AV Balar, A Necchi, N Dawson, PH O'Donnell, A Balmanoukian, Y Loriot, S Srinivas, MM Retz, P Grivas, RW Joseph, MD Galsky, MT Fleming, DP Petrylak, JL Perez-Gracia, HA Burris, D Castellano, C Canil, J Bellmunt, D Bajorin, D Nickles, R Bourgon, GM Frampton, N Cui, S Mariathasan, O Abidoye, GD Fine, R Dreicer; citation_volume=387; citation_issue=10031; citation_publication_date=2016; citation_pages=1909-1920; citation_doi=10.1016/s0140-6736(16)00561-4; citation_id=CR11 citation_journal_title=Cureus; citation_title=Anti-programmed cell death protein 1 (PD-1) immunotherapy for metastatic hepatocellular carcinoma after liver transplantation: a report of three cases; citation_author=O Al Jarroudi, A Ulusakarya, W Almohamad, S Afqir, JF Morere; citation_volume=12; citation_issue=10; citation_publication_date=2020; citation_pages=e11150; citation_doi=10.7759/cureus.11150; citation_id=CR12 citation_journal_title=Transplant Dir; citation_title=Metastatic donor-derived malignancies following simultaneous pancreas-kidney transplant: three case reports and management strategies; citation_author=D Amara, SA Wisel, HJ Braun, EA Collisson, T Friedlander, G Worner, GR Roll, R Hirose, PG Stock; citation_volume=7; citation_issue=1; citation_publication_date=2021; citation_pages=e636; citation_doi=10.1097/txd.0000000000001090; citation_id=CR13 citation_journal_title=J Clin Exp Hepatol; citation_title=Successful treatment of disseminated hepatocellular carcinoma after liver transplantation with Nivolumab; citation_author=W Amjad, S Kotiah, A Gupta, M Morris, L Liu, PJ Thuluvath; citation_volume=10; citation_issue=2; citation_publication_date=2020; citation_pages=185-187; citation_doi=10.1016/j.jceh.2019.11.009; citation_id=CR14 citation_journal_title=ACG Case Rep J; citation_title=Nivolumab-induced autoimmune-like cholestatic hepatitis in a liver transplant recipient; citation_author=C Anugwom, T Leventhal; citation_volume=7; citation_issue=7; citation_publication_date=2020; citation_pages=e00416; citation_doi=10.14309/crj.0000000000000416; citation_id=CR15 citation_journal_title=N Engl J Med; citation_title=Preserved renal-allograft function and the PD-1 pathway inhibitor Nivolumab; citation_author=R Barnett, VS Barta, KD Jhaveri; citation_volume=376; citation_issue=2; citation_publication_date=2017; citation_pages=191-192; citation_doi=10.1056/NEJMc1614298; citation_id=CR16 citation_journal_title=Ann Oncol; citation_title=Safety of an anti-PD-1 immune checkpoint inhibitor in a liver transplant recipient; citation_author=P Biondani, E Martin, D Samuel; citation_volume=29; citation_issue=1; citation_publication_date=2018; citation_pages=286-287; citation_doi=10.1093/annonc/mdx548; citation_id=CR17 citation_journal_title=Am J Transpl Off J Am Soc Transpl Am Soc Transpl Surg; citation_title=Use of the PD-1 pathway inhibitor nivolumab in a renal transplant patient with malignancy; citation_author=CL Boils, DN Aljadir, AW Cantafio; citation_volume=16; citation_issue=8; citation_publication_date=2016; citation_pages=2496-2497; citation_doi=10.1111/ajt.13786; citation_id=CR18 citation_journal_title=J Thorac Oncol; citation_title=Nivolumab induced hepatocanalicular cholestasis and liver rejection in a patient with lung cancer and liver transplant; citation_author=M Braun, V Fuchs, W Kian, L Roisman, N Peled, E Rosenberg, L Friedel; citation_volume=15; citation_issue=9; citation_publication_date=2020; citation_pages=e149-e150; citation_doi=10.1016/j.jtho.2020.01.026; citation_id=CR19 citation_journal_title=Transpl Proc; citation_title=Resolution of a high grade and metastatic bk polyomavirus-associated urothelial cell carcinoma following radical allograft nephroureterectomy and immune checkpoint treatment: a case report; citation_author=AG Cuenca, I Rosales, RJ Lee, CL Wu, R Colvin, AS Feldman, JA Efstathiou, N Tolkoff-Rubin, N Elias; citation_volume=52; citation_issue=9; citation_publication_date=2020; citation_pages=2720-2725; citation_doi=10.1016/j.transproceed.2020.06.012; citation_id=CR20 citation_journal_title=Cancer Immunol Immunother CII; citation_title=Impact of corticosteroids on allograft protection in renal transplant patients receiving anti-PD-1 immunotherapy; citation_author=MJ Danesh, PM Mulvaney, N Murakami, LV Riella, AW Silk, GJ Hanna, CD Schmults; citation_volume=69; citation_issue=9; citation_publication_date=2020; citation_pages=1937-1941; citation_doi=10.1007/s00262-020-02644-2; citation_id=CR21 citation_journal_title=Gastroenterology; citation_title=Tapering of immunosuppression and sustained treatment with nivolumab in a liver transplant recipient; citation_author=EN Toni, AL Gerbes; citation_volume=152; citation_issue=6; citation_publication_date=2017; citation_pages=1631-1633; citation_doi=10.1053/j.gastro.2017.01.063; citation_id=CR22 citation_journal_title=J Gastrointest Oncol; citation_title=Pilot evaluation of PD-1 inhibition in metastatic cancer patients with a history of liver transplantation: the Mayo Clinic experience; citation_author=TT DeLeon, MA Salomao, BA Aqel, MB Sonbol, RT Yokoda, AH Ali, AA Moss, AK Mathur, DM Chascsa, J Rakela, AH Bryce, MJ Borad; citation_volume=9; citation_issue=6; citation_publication_date=2018; citation_pages=1054-1062; citation_doi=10.21037/jgo.2018.07.05; citation_id=CR23 citation_journal_title=Ann Oncol; citation_title=Acute liver graft rejection after ipilimumab therapy; citation_author=S Dueland, TK Guren, KM Boberg, HM Reims, K Grzyb, S Aamdal, L Julsrud, PD Line; citation_volume=28; citation_issue=10; citation_publication_date=2017; citation_pages=2619-2620; citation_doi=10.1093/annonc/mdx281; citation_id=CR24 citation_journal_title=Pediatr Blood Cancer; citation_title=Fatal orthotopic liver transplant organ rejection induced by a checkpoint inhibitor in two patients with refractory, metastatic hepatocellular carcinoma; citation_author=BD Friend, RS Venick, SV McDiarmid, X Zhou, B Naini, H Wang, DG Farmer, RW Busuttil, N Federman; citation_publication_date=2017; citation_doi=10.1002/pbc.26682; citation_id=CR25 citation_journal_title=Transplant Dir; citation_title=Liver allograft failure after nivolumab treatment-a case report with systematic literature research; citation_author=D Gassmann, S Weiler, JC Mertens, CS Reiner, B Vrugt, M Nägeli, J Mangana, B Müllhaupt, F Jenni, B Misselwitz; citation_volume=4; citation_issue=8; citation_publication_date=2018; citation_pages=e376; citation_doi=10.1097/txd.0000000000000814; citation_id=CR26 citation_journal_title=BMC Nephrol; citation_title=PD 1 checkpoint inhibition in solid organ transplants: 2 sides of a coin—case report; citation_author=JW Goldman, B Abdalla, MA Mendenhall, A Sisk, J Hunt, GM Danovitch, EL Lum; citation_volume=19; citation_issue=1; citation_publication_date=2018; citation_pages=210; citation_doi=10.1186/s12882-018-1003-5; citation_id=CR27 citation_journal_title=Melanoma Manag; citation_title=Checkpoint inhibitor use in two heart transplant patients with metastatic melanoma and review of high-risk populations; citation_author=MJ Grant, N DeVito, AKS Salama; citation_volume=5; citation_issue=4; citation_publication_date=2018; citation_pages=Mmt10; citation_doi=10.2217/mmt-2018-0004; citation_id=CR28 citation_journal_title=Eur J Cancer (Oxford, England: 1990); citation_title=CMV disease and colitis in a kidney transplanted patient under pembrolizumab; citation_author=J Gueguen, E Bailly, L Machet, E Miquelestorena-Standley, K Stefic, P Gatault, M Büchler; citation_volume=109; citation_publication_date=2019; citation_pages=172-174; citation_doi=10.1016/j.ejca.2018.12.027; citation_id=CR29 citation_journal_title=Melanoma Res; citation_title=The successful use of pembrolizumab in a renal transplant recipient with metastatic melanoma; citation_author=DL Hanna, SJ Law, SA Merrick, L Heptinstall, P Bass, P Dupont, A Sheri; citation_volume=30; citation_issue=3; citation_publication_date=2020; citation_pages=321-324; citation_doi=10.1097/cmr.0000000000000651; citation_id=CR30 citation_journal_title=Eur J Cancer (Oxford, England: 1990); citation_title=Checkpoint inhibitors in chronic kidney failure and an organ transplant recipient; citation_author=S Herz, T Höfer, M Papapanagiotou, JC Leyh, S Meyenburg, D Schadendorf, S Ugurel, A Roesch, E Livingstone, B Schilling, C Franklin; citation_volume=67; citation_publication_date=2016; citation_pages=66-72; citation_doi=10.1016/j.ejca.2016.07.026; citation_id=CR31 citation_journal_title=J Immunother Cancer; citation_title=Donor-derived cell-free DNA detects kidney transplant rejection during nivolumab treatment; citation_author=DP Hurkmans, J Verhoeven, K Leur, K Boer, A Joosse, CC Baan, JH Thüsen, RHN Schaik, RHJ Mathijssen, AAM Veldt, DA Hesselink; citation_volume=7; citation_issue=1; citation_publication_date=2019; citation_pages=182; citation_doi=10.1186/s40425-019-0653-6; citation_id=CR32 citation_journal_title=Transpl Proc; citation_title=Renal allograft failure after ipilimumab therapy for metastatic melanoma: a case report and review of the literature; citation_author=A Jose, P Yiannoullou, S Bhutani, H Denley, M Morton, M Picton, A Summers, D Dellen, T Augustine; citation_volume=48; citation_issue=9; citation_publication_date=2016; citation_pages=3137-3141; citation_doi=10.1016/j.transproceed.2016.07.019; citation_id=CR33 citation_journal_title=Oncologist; citation_title=The safety and efficacy of checkpoint inhibitors in transplant recipients: a case series and systematic review of literature; citation_author=V Kumar, AB Shinagare, HG Rennke, S Ghai, JH Lorch, PA Ott, OE Rahma; citation_volume=25; citation_issue=6; citation_publication_date=2020; citation_pages=505-514; citation_doi=10.1634/theoncologist.2019-0659; citation_id=CR34 citation_journal_title=Melanoma Res; citation_title=Immune checkpoint inhibitor therapy in a liver transplant recipient with a rare subtype of melanoma: a case report and literature review; citation_author=JC Kuo, LB Lilly, D Hogg; citation_volume=28; citation_issue=1; citation_publication_date=2018; citation_pages=61-64; citation_doi=10.1097/cmr.0000000000000410; citation_id=CR35 citation_journal_title=Lung Cancer; citation_title=Corneal graft rejection in a patient treated with nivolumab for primary lung cancer; citation_author=S Fournis, P Gohier, T Urban, T Jeanfaivre, J Hureaux; citation_volume=102; citation_publication_date=2016; citation_pages=28-29; citation_doi=10.1016/j.lungcan.2016.10.008; citation_id=CR36 citation_journal_title=N Engl J Med; citation_title=Tumor regression and allograft rejection after administration of anti-PD-1; citation_author=EJ Lipson, SM Bagnasco, J Moore, S Jang, MJ Patel, AA Zachary, DM Pardoll, JM Taube, CG Drake; citation_volume=374; citation_issue=9; citation_publication_date=2016; citation_pages=896-898; citation_doi=10.1056/NEJMc1509268; citation_id=CR37 citation_journal_title=J Clin Oncol Off J Am Soc Clin Oncol; citation_title=Successful administration of ipilimumab to two kidney transplantation patients with metastatic melanoma; citation_author=EJ Lipson, MA Bodell, ES Kraus, WH Sharfman; citation_volume=32; citation_issue=19; citation_publication_date=2014; citation_pages=e69-71; citation_doi=10.1200/jco.2013.49.2314; citation_id=CR38 citation_journal_title=Am J Transplant Off J Am Soc Transplant Am Soc Transplant Surg; citation_title=Kidney retransplantation after anti-programmed cell death-1 (PD-1)-related allograft rejection; citation_author=EJ Lipson, FF Naqvi, MJ Loss, MD Schollenberger, DM Pardoll, J Moore, DC Brennan; citation_volume=20; citation_issue=8; citation_publication_date=2020; citation_pages=2264-2268; citation_doi=10.1111/ajt.15856; citation_id=CR39 citation_journal_title=Emerg Infect Dis; citation_title=Effectiveness of immune checkpoint inhibitors in transplant recipients with progressive multifocal leukoencephalopathy; citation_author=C Medrano, F Vergez, C Mengelle, S Faguer, N Kamar, A Bello; citation_volume=25; citation_issue=11; citation_publication_date=2019; citation_pages=2145-2147; citation_doi=10.3201/eid2511.190705; citation_id=CR40 citation_journal_title=Am J Transplant Off J Am Soc Transplant Am Soc Transplant Surg; citation_title=Immune checkpoint inhibitor therapy-associated graft intolerance syndrome in a failed kidney transplant recipient; citation_author=CD Mejia, AM Frank, P Singh, A Yadav; citation_publication_date=2020; citation_doi=10.1111/ajt.16326; citation_id=CR41 citation_journal_title=JAAD Case Rep; citation_title=Complete pathologic response of metastatic cutaneous squamous cell carcinoma and allograft rejection after treatment with combination immune checkpoint blockade; citation_author=DM Miller, BE Faulkner-Jones, JR Stone, RE Drews; citation_volume=3; citation_issue=5; citation_publication_date=2017; citation_pages=412-415; citation_doi=10.1016/j.jdcr.2017.06.005; citation_id=CR42 citation_journal_title=J Immunother Cancer; citation_title=Safety and efficacy of ipilimumab to treat advanced melanoma in the setting of liver transplantation; citation_author=RE Morales, AN Shoushtari, MM Walsh, P Grewal, EJ Lipson, RD Carvajal; citation_volume=3; citation_publication_date=2015; citation_pages=22; citation_doi=10.1186/s40425-015-0066-0; citation_id=CR43 citation_journal_title=J Immunother Cancer; citation_title=Antitumor activity of nivolumab on hemodialysis after renal allograft rejection; citation_author=M Ong, AM Ibrahim, S Bourassa-Blanchette, C Canil, T Fairhead, G Knoll; citation_volume=4; citation_publication_date=2016; citation_pages=64; citation_doi=10.1186/s40425-016-0171-8; citation_id=CR44 citation_journal_title=Cancer Immunol Immunother CII; citation_title=Cardiac allograft rejection as a complication of PD-1 checkpoint blockade for cancer immunotherapy: a case report; citation_author=TK Owonikoko, M Kumar, S Yang, AO Kamphorst, RN Pillai, R Akondy, V Nautiyal, MS Chatwal, WM Book, A Sahu, GL Sica, R Ahmed, SS Ramalingam; citation_volume=66; citation_issue=1; citation_publication_date=2017; citation_pages=45-50; citation_doi=10.1007/s00262-016-1918-2; citation_id=CR45 citation_journal_title=J Oncol Pharm Pract Off Publ Int Soc Oncol Pharm Pract; citation_title=Pembrolizumab-induced severe rejection and graft intolerance syndrome resulting in renal allograft nephrectomy; citation_author=SA Padala, SK Patel, A Vakiti, N Patel, I Gani, R Kapoor, S Muhammad; citation_publication_date=2020; citation_doi=10.1177/1078155220934160; citation_id=CR46 citation_journal_title=Immunotherapy; citation_title=Ipilumumab for hepatocellular cancer in a liver transplant recipient, with durable response, tolerance and without allograft rejection; citation_author=A Pandey, DJ Cohen; citation_volume=12; citation_issue=5; citation_publication_date=2020; citation_pages=287-292; citation_doi=10.2217/imt-2020-0014; citation_id=CR47 citation_journal_title=Rev Mal Respir; citation_title=Concomitant use of nivolumab and immunosuppressants in a renal transplant patient; citation_author=H Pluchart, L Ferrer, D Giovannini, R Tetaz, J Pinsolle, O Stephanov, M Giaj Levra, D Moro-Sibilot, AC Toffart; citation_volume=36; citation_issue=9; citation_publication_date=2019; citation_pages=1064-1068; citation_doi=10.1016/j.rmr.2019.08.004; citation_id=CR48 citation_journal_title=Melanoma Manag; citation_title=Report of ipilimumab in a heart transplant patient with metastatic melanoma on tacrolimus; citation_author=R Qin, AK Salama; citation_volume=2; citation_issue=4; citation_publication_date=2015; citation_pages=311-314; citation_doi=10.2217/mmt.15.27; citation_id=CR49 citation_journal_title=Hepatology (Baltimore, MD); citation_title=Pembrolizumab for metastatic hepatocellular carcinoma following live donor liver transplantation: the silver bullet?; citation_author=A Rammohan, MS Reddy, M Farouk, J Vargese, M Rela; citation_volume=67; citation_issue=3; citation_publication_date=2018; citation_pages=1166-1168; citation_doi=10.1002/hep.29575; citation_id=CR50 citation_journal_title=J Immunother (Hagerstown, Md: 1997); citation_title=Administration of ipilimumab to a liver transplant recipient with unresectable metastatic melanoma; citation_author=HA Ranganath, TJ Panella; citation_volume=38; citation_issue=5; citation_publication_date=2015; citation_pages=211; citation_doi=10.1097/cji.0000000000000077; citation_id=CR51 citation_journal_title=J Oncol Pract; citation_title=Complete tumor response to pembrolizumab and allograft preservation in renal allograft recipient on immunosuppressive therapy; citation_author=M Sadaat, S Jang; citation_volume=14; citation_issue=3; citation_publication_date=2018; citation_pages=198-199; citation_doi=10.1200/jop.2017.027326; citation_id=CR52 citation_journal_title=Ann Intern Med; citation_title=Immune checkpoint inhibitor therapy in a liver transplant recipient with melanoma; citation_author=G Schvartsman, K Perez, G Sood, R Katkhuda, H Tawbi; citation_volume=167; citation_issue=5; citation_publication_date=2017; citation_pages=361-362; citation_doi=10.7326/l17-0187; citation_id=CR53 citation_journal_title=Transplantation; citation_title=Preserved renal allograft function and successful treatment of metastatic merkel cell cancer post nivolumab therapy; citation_author=P Singh, J Visger, J Prosek, B Rovin, TE Pesavento, T Olencki, D Pandey; citation_volume=103; citation_issue=2; citation_publication_date=2019; citation_pages=e52-e53; citation_doi=10.1097/tp.0000000000002502; citation_id=CR54 citation_journal_title=Transpl Proc; citation_title=Use of Ipilimumab and Pembrolizumab in metastatic melanoma in a combined heart and kidney transplant recipient: a case report; citation_author=I Soellradl, H Kehrer, D Cejka; citation_volume=52; citation_issue=2; citation_publication_date=2020; citation_pages=657-659; citation_doi=10.1016/j.transproceed.2019.09.014; citation_id=CR55 citation_journal_title=Ann Oncol; citation_title=Acute renal allograft rejection after immune checkpoint inhibitor therapy for metastatic melanoma; citation_author=L Spain, R Higgins, K Gopalakrishnan, S Turajlic, M Gore, J Larkin; citation_volume=27; citation_issue=6; citation_publication_date=2016; citation_pages=1135-1137; citation_doi=10.1093/annonc/mdw130; citation_id=CR56 citation_journal_title=Eur J Cancer (Oxford, England: 1990); citation_title=Anti-PD-1/PD-L1 immunotherapy in patients with solid organ transplant, HIV or hepatitis B/C infection; citation_author=M Tio, R Rai, OM Ezeoke, JL McQuade, L Zimmer, C Khoo, JJ Park, L Spain, S Turajlic, L Ardolino, D Yip, SM Goldinger, JV Cohen, M Millward, V Atkinson, AY Kane, PA Ascierto, C Garbe, R Gutzmer, DB Johnson, HA Rizvi, AM Joshua, MD Hellmann, GV Long, AM Menzies; citation_volume=104; citation_publication_date=2018; citation_pages=137-144; citation_doi=10.1016/j.ejca.2018.09.017; citation_id=CR57 citation_journal_title=J Immunother cancer; citation_title=Combination checkpoint blockade for metastatic cutaneous malignancies in kidney transplant recipients; citation_author=MH Trager, SM Coley, G Dube, S Khan, M Ingham, FH Samie, LJ Geskin, D McDonnell, D Brouder, Y Saenger, R Carvajal; citation_publication_date=2020; citation_doi=10.1136/jitc-2020-000908; citation_id=CR58 citation_journal_title=Oncologist; citation_title=A pilot study of checkpoint inhibitors in solid organ transplant recipients with metastatic cutaneous squamous cell carcinoma; citation_author=I Tsung, FP Worden, RJ Fontana; citation_publication_date=2020; citation_doi=10.1002/onco.13539; citation_id=CR59 citation_journal_title=Cornea; citation_title=Bilateral corneal graft rejection associated with pembrolizumab treatment; citation_author=E Vahonsebrouck, E Walle Mn, W Lybaert, V Kruse, D Roels; citation_volume=39; citation_issue=11; citation_publication_date=2020; citation_pages=1436-1438; citation_doi=10.1097/ico.0000000000002372; citation_id=CR60 citation_journal_title=Transplantation; citation_title=Poor outcomes with the use of checkpoint inhibitors in kidney transplant recipients; citation_author=K Venkatachalam, AF Malone, B Heady, RD Santos, T Alhamad; citation_volume=104; citation_issue=5; citation_publication_date=2020; citation_pages=1041-1047; citation_doi=10.1097/tp.0000000000002914; citation_id=CR61 citation_journal_title=J Immunother (Hagerstown, Md: 1997); citation_title=Safe administration of An anti-PD-1 antibody to kidney-transplant patients: 2 clinical cases and review of the literature; citation_author=JK Winkler, R Gutzmer, C Bender, N Lang, M Zeier, AH Enk, JC Hassel; citation_volume=40; citation_issue=9; citation_publication_date=2017; citation_pages=341-344; citation_doi=10.1097/cji.0000000000000188; citation_id=CR62 citation_journal_title=Transpl Proc; citation_title=Safety and efficacy of immune checkpoint inhibitors in patients with metastatic cancer post solid organ transplantation: a case report and review of the literature; citation_author=K Wong, J Shen, S D'Ambruoso, D Stefanoudakis, A Drakaki; citation_volume=51; citation_issue=9; citation_publication_date=2019; citation_pages=3053-3058; citation_doi=10.1016/j.transproceed.2019.08.002; citation_id=CR63 citation_journal_title=Ann Oncol; citation_title=Tumor regression and preservation of graft function after combination with anti-PD-1 immunotherapy without immunosuppressant titration; citation_author=CK Wu, GD Juang, HC Lai; citation_volume=28; citation_issue=11; citation_publication_date=2017; citation_pages=2895-2896; citation_doi=10.1093/annonc/mdx409; citation_id=CR64 citation_journal_title=Am J Transplant Off J Am Soc Transplant Am Soc Transplant Surg; citation_title=Ipilimumab for the treatment of advanced melanoma in six kidney transplant patients; citation_author=O Zehou, C Leibler, JP Arnault, J Sayegh, H Montaudié, P Rémy, D Glotz, C Cordonnier, L Martin, C Lebbé; citation_volume=18; citation_issue=12; citation_publication_date=2018; citation_pages=3065-3071; citation_doi=10.1111/ajt.15071; citation_id=CR65 citation_journal_title=Hepatobiliary Pancreat Dis Int: HBPD INT; citation_title=Immune checkpoint inhibitor for hepatocellular carcinoma recurrence after liver transplantation; citation_author=L Zhuang, HB Mou, LF Yu, HK Zhu, Z Yang, Q Liao, SS Zheng; citation_volume=19; citation_issue=1; citation_publication_date=2020; citation_pages=91-93; citation_doi=10.1016/j.hbpd.2019.09.011; citation_id=CR66 citation_journal_title=Am J Transplant; citation_title=Fatal hepatic necrosis after nivolumab as a bridge to liver transplant for HCC: Are checkpoint inhibitors safe for the pretransplant patient?; citation_author=MF Nordness, S Hamel, CM Godfrey, C Shi, DB Johnson, LW Goff, H O’Dell, RE Perri, SP Alexopoulos; citation_volume=20; citation_issue=3; citation_publication_date=2020; citation_pages=879-883; citation_doi=10.1111/ajt.15617; citation_id=CR67 citation_journal_title=J Thorac Oncol; citation_title=EP1.04–32 successful corneal transplantation in a patient treated with nivolumab for metastatic non-small cell lung cancer; citation_author=C Dutra, BR Garcia, R Vieira, AC Figueiredo, Y Néron; citation_volume=14; citation_issue=10; citation_publication_date=2019; citation_pages=S981; citation_doi=10.1016/j.jtho.2019.08.2155; citation_id=CR68 citation_journal_title=Am J Gastroenterol; citation_title=Nivolumab-induced severe allograft rejection in recurrent post-transplant hepatocellular carcinoma; citation_author=S Kumar; citation_volume=114; citation_publication_date=2019; citation_pages=S1251-S1252; citation_doi=10.14309/01.ajg.0000598472.41771.5f; citation_id=CR69 citation_journal_title=Asia Pac J Clin Oncol; citation_title=Pembrolizumab for metastatic melanoma in renal allograft recipient with subsequent graft rejection and treatment response failure, a case report; citation_author=V Kwatra, N Karanth, K Priyadarshana, M Charakidis; citation_volume=12; citation_publication_date=2016; citation_pages=119-120; citation_id=CR70 citation_journal_title=Am J Transplant; citation_title=Nivolumab-induced rejection of a liver allograft: PD-1 inhibition thwarts liver allograft resistance to humoral rejection; citation_author=BT Lee, H Han, S Chopra, AJ Aheam; citation_volume=19; citation_publication_date=2019; citation_pages=1077-1078; citation_doi=10.1111/ajt.15406; citation_id=CR71 citation_journal_title=Transpl Int; citation_title=Donor-derived cell-free DNA detects kidney transplant rejection during nivolumab treatment; citation_author=J Verhoeven, D Hurkmans, K Leur, K Boer, A Joosse, C Baan, J Thüsen, R Schaik, R Mathijssen, A Veldt, D Hesselink; citation_volume=32; citation_publication_date=2019; citation_pages=337; citation_id=CR72 citation_journal_title=Support Care Cancer Off J Multinatl Assoc Support Care Cancer; citation_title=Prognostic accuracy of the sequential organ failure assessment (SOFA) and quick SOFA for mortality in cancer patients with sepsis defined by systemic inflammatory response syndrome (SIRS); citation_author=BR Chae, YJ Kim, YS Lee; citation_volume=28; citation_issue=2; citation_publication_date=2020; citation_pages=653-659; citation_doi=10.1007/s00520-019-04869-z; citation_id=CR73 citation_journal_title=Lancet Oncol; citation_title=Barcelona clinic liver cancer staging and transplant survival benefit for patients with hepatocellular carcinoma: a multicentre, cohort study; citation_author=A Vitale, RR Morales, G Zanus, F Farinati, P Burra, P Angeli, AC Frigo, P Poggio, G Rapaccini, MA Nolfo, L Benvegnù, M Zoli, F Borzio, EG Giannini, E Caturelli, M Chiaramonte, F Trevisani, U Cillo; citation_volume=12; citation_issue=7; citation_publication_date=2011; citation_pages=654-662; citation_doi=10.1016/s1470-2045(11)70144-9; citation_id=CR74 citation_journal_title=Lancet Oncol; citation_title=Solid organ transplantation after treatment for childhood cancer: a retrospective cohort analysis from the Childhood Cancer Survivor Study; citation_author=AC Dietz, K Seidel, WM Leisenring, DA Mulrooney, JM Tersak, RD Glick, CA Burnweit, DM Green, LR Diller, SA Smith, RM Howell, M Stovall, GT Armstrong, KC Oeffinger, LL Robison, AM Termuhlen; citation_volume=20; citation_issue=10; citation_publication_date=2019; citation_pages=1420-1431; citation_doi=10.1016/s1470-2045(19)30418-8; citation_id=CR75 citation_journal_title=Transplantation; citation_title=Outcomes of solid organ transplant recipients with preexisting malignancies in remission: a systematic review and meta-analysis; citation_author=SA Acuna, JW Huang, C Daly, PS Shah, SJ Kim, NN Baxter; citation_volume=101; citation_issue=3; citation_publication_date=2017; citation_pages=471-481; citation_doi=10.1097/tp.0000000000001192; citation_id=CR76 citation_journal_title=Transplant Rev (Orlando); citation_title=Cancer recurrence after solid organ transplantation: A systematic review and meta-analysis; citation_author=SA Acuna, JW Huang, F Dossa, PS Shah, SJ Kim, NN Baxter; citation_volume=31; citation_issue=4; citation_publication_date=2017; citation_pages=240-248; citation_doi=10.1016/j.trre.2017.08.003; citation_id=CR77 Gogna S, Ramakrishna K, John S (2020) Post transplantation cancer. In: StatPearls. StatPearls Publishing, Copyright© 2020, StatPearls Publishing LLC., Treasure Island citation_journal_title=Nat Commun; citation_title=Targeting the mTOR pathway uncouples the efficacy and toxicity of PD-1 blockade in renal transplantation; citation_author=K Esfahani, TA Al-Aubodah, P Thebault, R Lapointe, M Hudson, NA Johnson, D Baran, N Bhulaiga, T Takano, JF Cailhier, CA Piccirillo, WH Miller; citation_volume=10; citation_issue=1; citation_publication_date=2019; citation_pages=4712; citation_doi=10.1038/s41467-019-12628-1; citation_id=CR79 citation_journal_title=Eur J Clin Pharmacol; citation_title=The incidence of post-transplant cancer among kidney transplant recipients is associated with the level of tacrolimus exposure during the first year after transplantation; citation_author=S Lichtenberg, R Rahamimov, H Green, BD Fox, E Mor, U Gafter, A Chagnac, B Rozen-Zvi; citation_volume=73; citation_issue=7; citation_publication_date=2017; citation_pages=819-826; citation_doi=10.1007/s00228-017-2234-2; citation_id=CR80 citation_journal_title=Int Immunopharmacol; citation_title=The change of immunosuppressive regimen from calcineurin inhibitors to mammalian target of rapamycin (mTOR) inhibitors and its effect on malignancy following heart transplantation; citation_author=N Saber-Moghaddam, H Nomani, A Sahebkar, TP Johnston, AH Mohammadpour; citation_volume=69; citation_publication_date=2019; citation_pages=150-158; citation_doi=10.1016/j.intimp.2019.01.035; citation_id=CR81 citation_journal_title=Clin Transplant; citation_title=Immune function assay (ImmuKnow) as a predictor of allograft rejection and infection in kidney transplantation; citation_author=J He, Y Li, H Zhang, X Wei, H Zheng, C Xu, X Bao, X Yuan, J Hou; citation_volume=27; citation_issue=4; citation_publication_date=2013; citation_pages=E351-358; citation_doi=10.1111/ctr.12134; citation_id=CR82 citation_journal_title=Am J Transplant Off J Am Soc Transplant Am Soc Transplant Surg; citation_title=Efficacy and tolerance of immune checkpoint inhibitors in transplant patients with cancer: a systematic review; citation_author=T d'Izarny-Gargas, A Durrbach, M Zaidan; citation_volume=20; citation_issue=9; citation_publication_date=2020; citation_pages=2457-2465; citation_doi=10.1111/ajt.15811; citation_id=CR83 citation_journal_title=Front Oncol; citation_title=Anti-PD-1 and Anti-CTLA-4 therapies in cancer: mechanisms of action, efficacy, and limitations; citation_author=JA Seidel, A Otsuka, K Kabashima; citation_volume=8; citation_publication_date=2018; citation_pages=86; citation_doi=10.3389/fonc.2018.00086; citation_id=CR84 citation_journal_title=JAMA Oncol; citation_title=Outcomes following immune checkpoint inhibitor treatment of patients with microsatellite instability-high cancers: a systematic review and meta-analysis; citation_author=F Petrelli, M Ghidini, A Ghidini, G Tomasello; citation_volume=6; citation_issue=7; citation_publication_date=2020; citation_pages=1068-1071; citation_doi=10.1001/jamaoncol.2020.1046; citation_id=CR85