Mechanical power at a glance: a simple surrogate for volume-controlled ventilation - 2019
Lorenzo Giosa, Mattia Busana, Iacopo Pasticci, Matteo Bonifazi, Matteo Maria Macrì, Federica Romitti, Francesco Vassalli, Davide Chiumello, Michael Quintel, John J. Marini, Luciano Gattinoni
AbstractBackgroundMechanical power is a summary variable including all the components which can possibly cause VILI (pressures, volume, flow, respiratory rate). Since the complexity of its mathematical computation is one of the major factors that delay its clinical use, we propose here a simple and easy to remember equation to est...... hiện toàn bộ The effects of airway pressure release ventilation on respiratory mechanics in extrapulmonary lung injury Tập 3 Số 1 - 2015
Michaela Kollisch‐Singule, Bryanna Emr, Sumeet Jain, Penny Andrews, Joshua Satalin, Jiao Liu, Elizabeth Porcellio, V. Kenyon, Guirong Wang, William Marx, Louis A. Gatto, Gary F. Nieman, Nader M. Habashi
Adrenomedullin binding improves catecholamine responsiveness and kidney function in resuscitated murine septic shock - 2013
Katja Wagner, Ulrich Wachter, J. Vogt, Angelika Scheuerle, Oscar McCook, Sandra Weber, Michael Gröger, Bettina Stahl, Michael Georgieff, Peter Möller, Andreas Bergmann, Frauke Hein, Enrico Calzia, Peter Radermacher, Florian Wagner
Abstract
Purpose
Adrenomedullin (ADM) has been referred to as a double-edged sword during septic shock: On one hand, ADM supplementation improved organ perfusion and function, attenuated systemic inflammation, and ultimately reduced tissue apoptosis and mortality. On th...... hiện toàn bộ The metabolic phenotype of rodent sepsis: cause for concern? Tập 1 Số 1 - 2013
Parjam Zolfaghari, Bernardo Bollen Pinto, Alex Dyson, Mervyn Singer
Abstract
Purpose
Rodent models of sepsis are frequently used to investigate pathophysiological mechanisms and to evaluate putative therapeutic strategies. However, preclinical efficacy in these models has failed to translate to the clinical setting. We thus questioned the representativeness of su...... hiện toàn bộ