Shape descriptors of the “never resting” microglia in three different acute brain injury models in mice Tập 3 Số 1 - 2015
Elisa R. Zanier, Stefano Fumagalli, Carlo Perego, Francesca Pischiutta, Maria-Grazia De Simoni
Abstract Background The study of microglia and macrophage (M/M) morphology
represents a key tool to understand the functional activation state and the
pattern of distribution of these cells in acute brain injury. The identification
of reliable quantitative morphological parameters is urgently needed to
understand these cell roles in brain injury and to explore strategies aimed at
therapeutically m... hiện toàn bộ
Mechanical power at a glance: a simple surrogate for volume-controlled ventilation - 2019
Lorenzo Giosa, Mattia Busana, Iacopo Pasticci, Matteo Bonifazi, Matteo Maria Macrì, Federica Romitti, Francesco Vassalli, Davide Chiumello, Michael Quintel, John J. Marini, Luciano Gattinoni
AbstractBackgroundMechanical power is a summary variable including all the
components which can possibly cause VILI (pressures, volume, flow, respiratory
rate). Since the complexity of its mathematical computation is one of the major
factors that delay its clinical use, we propose here a simple and easy to
remember equation to estimate mechanical power under volume-controlled
ventilation:$$ \mathr... hiện toàn bộ
The effects of airway pressure release ventilation on respiratory mechanics in extrapulmonary lung injury Tập 3 Số 1 - 2015
Michaela Kollisch‐Singule, Bryanna Emr, Sumeet Jain, Penny Andrews, Joshua Satalin, Jiao Liu, Elizabeth Porcellio, V. Kenyon, Guirong Wang, William Marx, Louis A. Gatto, Gary F. Nieman, Nader M. Habashi
Adrenomedullin binding improves catecholamine responsiveness and kidney function in resuscitated murine septic shock - 2013
Katja Wagner, Ulrich Wachter, J. Vogt, Angelika Scheuerle, Oscar McCook, Sandra Weber, Michael Gröger, Bettina Stahl, Michael Georgieff, Peter Möller, Andreas Bergmann, Frauke Hein, Enrico Calzia, Peter Radermacher, Florian Wagner
Abstract Purpose Adrenomedullin (ADM) has been referred to as a double-edged
sword during septic shock: On one hand, ADM supplementation improved organ
perfusion and function, attenuated systemic inflammation, and ultimately reduced
tissue apoptosis and mortality. On the other hand, ADM overproduction can cause
circulatory collapse and organ failure due to impaired vasoconstrictor response
and red... hiện toàn bộ
The metabolic phenotype of rodent sepsis: cause for concern? Tập 1 Số 1 - 2013
Parjam Zolfaghari, Bernardo Bollen Pinto, Alex Dyson, Mervyn Singer
Abstract Purpose Rodent models of sepsis are frequently used to investigate
pathophysiological mechanisms and to evaluate putative therapeutic strategies.
However, preclinical efficacy in these models has failed to translate to the
clinical setting. We thus questioned the representativeness of such models and
herein report a detailed comparison of the metabolic and cardiovascular
phenotypes of lon... hiện toàn bộ