Myeloperoxidase can differentiate between sepsis and non-infectious SIRS and predicts mortality in intensive care patients with SIRS

Kaukonen K-M, Bailey M, Pilcher D et al (2015) Systemic inflammatory response syndrome criteria in defining severe sepsis. N Engl J Med 372:1629–1638. doi: 10.1056/NEJMoa1415236

Brun Buisson C (2000) The epidemiology of the systemic inflammatory response. Intensive Care Med 26(Suppl 1):S64–S74

Angus DC, Linde-Zwirble WT, Lidicker J et al (2001) Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 29:1303–1310. doi: 10.1097/00003246-200107000-00002

Comstedt P, Storgaard M, Lassen AT (2009) The Systemic Inflammatory Response Syndrome (SIRS) in acutely hospitalised medical patients: a cohort study. Scand J Trauma Resusc Emerg Med 17:67. doi: 10.1186/1757-7241-17-67

Henriquez-Camacho C, Losa J (2014) Biomarkers for sepsis. Biomed Res Int. doi: 10.1155/2014/547818

Sandquist M, Wong HR (2014) Biomarkers of sepsis and their potential value in diagnosis, prognosis and treatment. Expert Rev Clin Immunol 10:1349–1356.

Klebanoff SJ (2005) Myeloperoxidase: friend and foe. J Leukoc Biol 77:598–625. doi: 10.1189/jlb.1204697.1

Winterbourn CC, Vissers MC, Kettle AJ (2000) Myeloperoxidase. Curr Opin Hematol 7:53–58

Hyseni A, Kemperman H, de Lange DW, et al (2013) Increased mortality in systemic inflammatory response syndrome patients with high levels of coagulation factor VIIa. J Thromb Haemost 2111–2117. doi: doi: 10.1111/jth.12427

Levy MM, Fink MP, Marshall JC et al (2003) 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Crit Care Med 31:1250–1256. doi: 10.1097/01.CCM.0000050454.01978.3B

Singer M, Deutchman CS, Seymour CW, et al (2016) The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). 315:801–810. doi: doi: 10.1001/jama.2016.0287

Kovach MA, Standiford TJ (2012) The function of neutrophils in sepsis. Curr Opin Infect Dis 25:321–327. doi: 10.1097/QCO.0b013e3283528c9b

Kothari N, Keshari RS, Bogra J et al (2011) Increased myeloperoxidase enzyme activity in plasma is an indicator of inflammation and onset of sepsis. J Crit Care 26:435.e1–435.e7. doi: 10.1016/j.jcrc.2010.09.001

Cha YS, Yoon JM, Jung WJ et al (2015) Evaluation of usefulness of myeloperoxidase index (MPXI) for differential diagnosis of systemic inflammatory response syndrome (SIRS) in the emergency department. Emerg Med J 32:304–307. doi: 10.1136/emermed-2013-203137

Chevrier I, Tregouet DA, Massonnet-Castel S et al (2006) Myeloperoxidase genetic polymorphisms modulate human neutrophil enzyme activity: genetic determinants for atherosclerosis? Atherosclerosis 188(1):150–154. doi: 10.1016/j.atherosclerosis.2005.10.012

Davies MJ (2011) Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention. J Clin Biochem Nutr 48(1):8–19. doi: 10.3164/jcbn.11-006FR

Rowland T, Hilliard H, Barlow G (2015) Procalcitonin: potential role in diagnosis and management of sepsis. Adv Clin Chem 68:71–86

Brown K, Brain S, Pearson J et al (2006) Neutrophils in development of multiple organ failure in sepsis. Lancet 368:157–169

Khan SQ, Kelly D, Quinn P et al (2007) Myeloperoxidase aids prognostication together with N-terminal pro-B-type natriuretic peptide in high-risk patients with acute ST elevation myocardial infarction. Heart 93:826–831. doi: 10.1136/hrt.2006.091041

Scharnagl H, Kleber ME, Genser B et al (2014) Association of myeloperoxidase with total and cardiovascular mortality in individuals undergoing coronary angiography—the LURIC study. Int J Cardiol 174:96–105. doi: 10.1016/j.ijcard.2014.03.168

Breslow MJ, Badawi O (2012) Severity scoring in the critically ill: part 1—interpretation and accuracy of outcome prediction scoring systems. Chest 141:245–252. doi: 10.1378/chest.11-0330

Keegan MT, Gajic O, Afessa B (2011) Severity of illness scoring systems in the intensive care unit. Crit Care Med 39:163–169. doi: 10.1097/CCM.0b013e3181f96f81