Losartan suppresses the inflammatory response in collagen-induced arthritis by inhibiting the MAPK and NF-κB pathways in B and T cellsInflammopharmacology - Tập 27 - Trang 487-502 - 2018
Xinming Wang, Xiaoyun Chen, Wei Huang, Pengying Zhang, Yawei Guo, Heinrich Körner, Huaxun Wu, Wei Wei
The angiotensin II type 1 receptor (AT1R) antagonist losartan has been confirmed to have a moderate anti-inflammatory effect in vitro and in vivo. However, how it affects immune cells in Rheumatoid Arthritis (RA) is still unknown. We found that in human synovial tissues, AT1R is significantly expressed on T cells and B cells. Treatment with losartan (15 mg/kg) alone and in combination with a low d...... hiện toàn bộ
The involvement of H2 receptor number on the regulation of histamine-mediated cell growthInflammopharmacology - Tập 8 - Trang 243-258 - 2000
Carlos Patricio Fitzsimons
Histamine has been implicated in the control of cell growth of diverse tissues and cell lines. The effect of histamine is mediated by the interaction with its specific receptors, which belong to the family of seven transmembrane G-protein-coupled receptors (GPCRs). However, the mechanism(s) involved and the factors that regulate this process have not yet been determined. In this article the releva...... hiện toàn bộ
SIRT1 pathway in Parkinson’s disease: a faraway snapshot but so closeInflammopharmacology - Tập 31 Số 1 - Trang 37-56 - 2023
Gaber El‐Saber Batiha, Hayder M Al-Kuraishy, Ali I. Al‐Gareeb, Engy Elekhnawy
AbstractSilent information regulator (SIRT) has distinctive enzymatic activities and physiological functions to control cell-cycle progression, gene expression, and DNA stability by targeting histone and non-histone proteins. SIRT1 enhances synaptic formation and synaptic activity, and therefore, can reduce the progression of various degenerative brain diseases inc...... hiện toàn bộ
Inflawell® improves neutrophil-to-lymphocyte ratio and shortens hospitalization in patients with moderate COVID-19, in a randomized double-blind placebo-controlled clinical trialInflammopharmacology - Tập 30 - Trang 465-475 - 2022
Sepideh Barzin Tond, Laurent Balenci, Nasim Khajavirad, Mohammadreza Salehi, Abbas Tafakhori, Mohammad Reza Shahmohammadi, Fereshteh Ghiasvand, Sirous Jafari, Sara Abolghasemi, Farzad Mokhtari, Somayyeh Mahmoodi Baram, Tayebe Zarei, Davood Kazemi, Esmaeil Mohammadnejad, Akram Shah-Hosseini, Alireza Haghbin Toutounchi, Soudabeh Fallah, Ali Riazi, Saeed Karima
COVID-19 is a significant global threat to public health. Despite the availability of vaccines and anti-viral drugs, there is an urgent need for alternative treatments to help prevent and/or manage COVID-19 symptoms and the underlying dysregulated immune response. We hypothesized that administration of Inflawell® syrup, a Boswellia extract formulation enriched for boswellic acids (BAs), can reduce...... hiện toàn bộ
Diabetes as one of the long-term COVID-19 complications: from the potential reason of more diabetic patients’ susceptibility to COVID-19 to the possible caution of future global diabetes tsunamiInflammopharmacology - - 2023
Yasamin Sharbatdar, Ronak Mousavian, Seyed Mostafa Noorbakhsh Varnosfaderani, Fatemeh Aziziyan, Mahsa Liaghat, Payam Baziyar, Ali Yousefi Rad, Chanour Tavakol, Amir Mansour Moeini, Mohsen Nabi‐Afjadi, Hamidreza Zalpoor, Fatemeh Kazemi‐Lomedasht