Losartan suppresses the inflammatory response in collagen-induced arthritis by inhibiting the MAPK and NF-κB pathways in B and T cellsInflammopharmacology - Tập 27 - Trang 487-502 - 2018
Xinming Wang, Xiaoyun Chen, Wei Huang, Pengying Zhang, Yawei Guo, Heinrich Körner, Huaxun Wu, Wei Wei
The angiotensin II type 1 receptor (AT1R) antagonist losartan has been confirmed to have a moderate anti-inflammatory effect in vitro and in vivo. However, how it affects immune cells in Rheumatoid Arthritis (RA) is still unknown. We found that in human synovial tissues, AT1R is significantly expressed on T cells and B cells. Treatment with losartan (15 mg/kg) alone and in combination with a low d...... hiện toàn bộ
The involvement of H2 receptor number on the regulation of histamine-mediated cell growthInflammopharmacology - Tập 8 - Trang 243-258 - 2000
Carlos Patricio Fitzsimons
Histamine has been implicated in the control of cell growth of diverse tissues and cell lines. The effect of histamine is mediated by the interaction with its specific receptors, which belong to the family of seven transmembrane G-protein-coupled receptors (GPCRs). However, the mechanism(s) involved and the factors that regulate this process have not yet been determined. In this article the releva...... hiện toàn bộ
Experimental antral ulcer and several protective drugsInflammopharmacology - Tập 10 - Trang 375-384 - 2002
C. R. Hung
Antral ulcer may result from infection of Helicobacter pylori, duodenal bile reflux or gastritis. Several animal antral ulcer models were used to evaluate protection of drugs. Chemicals used to induce antral ulcer were diethyldithiocarbamate, indomethacin and strong acid solutions. Because these treatments produce damage of gastrointestinal tissues other than the antrum, most of these ulcer models...... hiện toàn bộ
SIRT1 pathway in Parkinson’s disease: a faraway snapshot but so closeInflammopharmacology - Tập 31 Số 1 - Trang 37-56 - 2023
Gaber El‐Saber Batiha, Hayder M Al-Kuraishy, Ali I. Al‐Gareeb, Engy Elekhnawy
AbstractSilent information regulator (SIRT) has distinctive enzymatic activities and physiological functions to control cell-cycle progression, gene expression, and DNA stability by targeting histone and non-histone proteins. SIRT1 enhances synaptic formation and synaptic activity, and therefore, can reduce the progression of various degenerative brain diseases inc...... hiện toàn bộ