Inflammation and Regeneration

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Differentiation, functions, and roles of T follicular regulatory cells in autoimmune diseases
Inflammation and Regeneration - Tập 41 - Trang 1-8 - 2021
He Hao, Shingo Nakayamada, Yoshiya Tanaka
T follicular helper cells participate in stimulating germinal center (GC) formation and supporting B cell differentiation and autoantibody production. However, T follicular regulatory (Tfr) cells suppress B cell activation. Since changes in the number and functions of Tfr cells lead to dysregulated GC reaction and autoantibody response, targeting Tfr cells may benefit the treatment of autoimmune d...... hiện toàn bộ
Novel artificial nerve transplantation of human iPSC-derived neurite bundles enhanced nerve regeneration after peripheral nerve injury
Inflammation and Regeneration - Tập 44 - Trang 1-20 - 2024
Takayuki Nishijima, Kentaro Okuyama, Shinsuke Shibata, Hiroo Kimura, Munehisa Shinozaki, Takehito Ouchi, Yo Mabuchi, Tatsukuni Ohno, Junpei Nakayama, Manabu Hayatsu, Keiko Uchiyama, Tomoko Shindo, Eri Niiyama, Sayaka Toita, Jiro Kawada, Takuji Iwamoto, Masaya Nakamura, Hideyuki Okano, Narihito Nagoshi
Severe peripheral nerve damage always requires surgical treatment. Autologous nerve transplantation is a standard treatment, but it is not sufficient due to length limitations and extended surgical time. Even with the available artificial nerves, there is still large room for improvement in their therapeutic effects. Novel treatments for peripheral nerve injury are greatly expected. Using a specia...... hiện toàn bộ
Shear bioreactors stimulating chondrocyte regeneration, a systematic review
Inflammation and Regeneration - Tập 39 - Trang 1-8 - 2019
Anneh Mohammad Gharravi, Negar sharifi
It is commonly accepted that the mechanical stimuli are important factors in the maintenance of normal structure and function of the articular cartilage. Despite extensive efforts, the cellular mechanisms underlying the responses of articular chondrocytes to mechanical stresses are not well understood. In the present review, different types of shear bioreactor and potential mechanisms that mediate...... hiện toàn bộ
#Immunology #Cell Biology #Developmental Biology
Mechanical regulation of macrophage function - cyclic tensile force inhibits NLRP3 inflammasome-dependent IL-1β secretion in murine macrophages
Inflammation and Regeneration - Tập 39 - Trang 1-9 - 2019
Kentaro Maruyama, Eiji Nemoto, Satoru Yamada
Mechanical stress maintains tissue homeostasis by regulating many cellular functions including cell proliferation, differentiation, and inflammation and immune responses. In inflammatory microenvironments, macrophages in mechanosensitive tissues receive mechanical signals that regulate various cellular functions and inflammatory responses. Macrophage function is affected by several types of mechan...... hiện toàn bộ
Complement-targeted therapy: development of C5- and C5a-targeted inhibition
Inflammation and Regeneration - Tập 36 - Trang 1-5 - 2016
Takahiko Horiuchi, Hiroshi Tsukamoto
The complement system is a major effector of humoral immunity and natural immunity. The complement system has three independent pathways of complement activation: a classical pathway, an alternative pathway, and a lectin pathway. These pathways converge to a common pathway that activates C3. This pathway also leads to the formation of various bioactive molecules such as C5a and the formation of me...... hiện toàn bộ
A novel cell-free intrathecal approach with PRP for the treatment of spinal cord multiple sclerosis in cats
Inflammation and Regeneration - Tập 42 Số 1 - Trang 1-13 - 2022
Farid, Mariam F., Abouelela, Yara S., Yasin, Noha A. E., Mousa, Mohamed R., Ibrahim, Marwa A., Prince, Abdelbary, Rizk, Hamdy
Multiple sclerosis (MS) is a progressive autoimmune demyelinating disease of the central nervous system. To date, there is no effective therapy for it. Our study aimed to determine the potential role of platelet-rich plasma (PRP) in the treatment of MS in cats. The current study was conducted on 15 adult Persian cats that were divided into three groups: control negative, control positive (ethidium...... hiện toàn bộ
Role of circulating molecules in age-related cardiovascular and metabolic disorders
Inflammation and Regeneration - Tập 42 - Trang 1-16 - 2022
Yung Ting Hsiao, Ippei Shimizu, Yohko Yoshida, Tohru Minamino
Studies analyzing heterochronic parabiosis mice models showed that molecules in the blood of young mice rejuvenate aged mice. Therefore, blood-based therapies have become one of the therapeutic approaches to be considered for age-related diseases. Blood includes numerous biologically active molecules such as proteins, metabolites, hormones, miRNAs, etc. and accumulating evidence indicates some of ...... hiện toàn bộ
Targeting microglial autophagic degradation of the NLRP3 inflammasome for identification of thonningianin A in Alzheimer’s disease
Inflammation and Regeneration - - 2022
Xiao-Gang Zhou, Wen-Qiao Qiu, Lu Yu, Rong Pan, Jin-Feng Teng, Zhi-Pei Sang, Betty Yuen-Kwan Law, Ya Zhao, Li Zhang, Lu Yan, Yong Tang, Xiao-Lei Sun, Vincent Kam Wai Wong, Chong-Lin Yu, Jian-Ming Wu, Da-Lian Qin, An-Guo Wu
NLRP3 inflammasome-mediated neuroinflammation plays a critical role in the pathogenesis and development of Alzheimer’s disease (AD). Microglial autophagic degradation not only decreases the deposits of extracellular Aβ fibrils but also inhibits the activation of NRLP3 inflammasome. Here, we aimed to identify the potent autophagy enhancers from Penthorum chinense Pursh (PCP) that alleviate the path...... hiện toàn bộ
Atypical cholangiocytes derived from hepatocyte-cholangiocyte transdifferentiation mediated by COX-2: a kind of misguided liver regeneration
Inflammation and Regeneration - Tập 43 - Trang 1-13 - 2023
Tian Lan, Yang Tai, Chong Zhao, Yang Xiao, Zhu Yang, Linhao Zhang, Can Gan, Wenting Dai, Huan Tong, Chengwei Tang, Zhiyin Huang, Jinhang Gao
Hepatocyte-cholangiocyte transdifferentiation (HCT) is a potential origin of proliferating cholangiocytes in liver regeneration after chronic injury. This study aimed to determine HCT after chronic liver injury, verify the impacts of HCT on liver repair, and avoid harmful regeneration by understanding the mechanism. A thioacetamide (TAA)-induced liver injury model was established in wild-type (WT-...... hiện toàn bộ
Cell transfer technology for tissue engineering
Inflammation and Regeneration - Tập 37 Số 1 - 2017
Keiko Akazawa, Kengo Iwasaki, Mizuki Nagata, Naoki Yokoyama, Hirohito Ayame, Kazumasa Yamaki, Yuichi Tanaka, Izumi Honda, Chikako Morioka, Tsuyoshi Kimura, Motohiro Komaki, Akio Kishida, Yuichi Izumi, Ikuo Morita
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