In vitro models
ESCI-ISI
2731-3441
Cơ quản chủ quản: N/A
Các bài báo tiêu biểu
Electrical cell-substrate impedance sensing (ECIS) as a tool to study microbial-cell interactions
Tập 1 - Trang 323-331 - 2022
ECIS is an impedance-based method to study the cellular responses to a stimulus.
Manipulating the alternating current frequencies in ECIS helped reveal the
adherent monolayer properties, including morphology, spreading, proliferation,
changes in junctional proteins and barrier integrity. Our objective in the
current study was to understand the progression of Pseudomonas infection in the
airway epi...
Application of a 3D hydrogel-based model to replace use of animals for passaging patient-derived xenografts
Abstract Purpose This 3D in vitro cancer model for propagation of
patient-derived cells, using a synthetic self-assembling peptide gel, allows the
formation of a fully characterised, tailorable tumour microenvironment. Unlike
many existing 3D cancer models, the peptide gel is inert, apart from molecules
and motifs deliberately added or produced by cells within the model. Methods
Breast cancer pati...
Modelling neurodegeneration and inflammation in early diabetic retinopathy using 3D human retinal organoids
Tập 3 Số 1 - Trang 33-48
Abstract Purpose Diabetic retinopathy (DR) is a complication of diabetes and a
primary cause of visual impairment amongst working-age individuals. DR is a
degenerative condition in which hyperglycaemia results in morphological and
functional changes in certain retinal cells. Existing treatments mainly address
the advanced stages of the disease, which involve vascular defects or
neovascularization....