In vitro models

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Urgent action is required to increase sustainability in in vitro modelling
In vitro models - Tập 1 - Trang 115-117 - 2022
Katarina Pedersen, Anne Vanhoestenberghe, Susan Heavey
Inflammatory bowel disease addressed by Caco-2 and monocyte-derived macrophages: an opportunity for an in vitro drug screening assay
In vitro models - Tập 1 - Trang 365-383 - 2022
Sabrina Schnur, Vanessa Wahl, Julia K. Metz, Jessica Gillmann, Fabian Hans, Katharina Rotermund, Ralf-Kilian Zäh, Dietmar A. Brück, Marc Schneider, Marius Hittinger
Inflammatory bowel disease (IBD) is a widespread disease, affecting a growing demographic. The treatment of chronic inflammation located in the GI-tract is dependent on the severity; therefore, the IBD treatment pyramid is commonly applied. Animal experimentation plays a key role for novel IBD drug development; nevertheless, it is ethically questionable and limited in its throughput. Reliable and ...... hiện toàn bộ
Biological characterization of breast cancer spheroid formed by fast fabrication method
In vitro models - - Trang 1-14 - 2024
Yuta Iijima, Norino Uenaka, Mayu Morimoto, Daiki Sato, Satomi Hirose, Naoyoshi Sakitani, Masahiro Shinohara, Kenichi Funamoto, Gen Hayase, Daisuke Yoshino
Engineered three-dimensional (3D) tissue culture platforms are useful for reproducing and elucidating complex in vivo biological phenomena. Spheroids, 3D aggregates of living cells, are produced based on physicochemical or microfabrication technologies and are commonly used even in cancer pathology research. However, conventional methods have difficulties in constructing 3D structures depending on...... hiện toàn bộ
3D tumor spheroids: morphological alterations a yardstick to anti-cancer drug response
In vitro models - - Trang 1-30 - 2023
Anna Senrung, Sakshi Lalwani, Divya Janjua, Tanya Tripathi, Jasleen Kaur, Netra Ghuratia, Nikita Aggarwal, Arun Chhokar, Joni Yadav, Apoorva Chaudhary, Udit Joshi, Alok Chandra Bharti
Tumor spheroids are one of the well-characterized 3D culture systems bearing close resemblance to the physiological tissue organization and complexity of avascular solid tumor stage with hypoxic core. They hold a wide-spread application in the field of pharmaceutical science and anti-cancer drug research. However, the difficulty in determining optimal technique for the generation of spheroids with...... hiện toàn bộ
Ex vivo evaluation of blood coagulation on endothelial glycocalyx-inspired surfaces using thromboelastography
In vitro models - Tập 1 - Trang 59-71 - 2021
Yanyi Zang, Jessi R. Vlcek, Jamie Cuchiaro, Ketul C. Popat, Christine S. Olver, Matt J. Kipper, Melissa M. Reynolds
Present blood-contacting materials have not yet demonstrated to be effective in reducing blood coagulation without causing additional side effects clinically. We have developed an endothelial glycocalyx-inspired biomimetic surface that combines nanotopography, heparin presentation, and nitric oxide (NO)-releasing features. The resulting modified surfaces have already shown promise in reducing unfa...... hiện toàn bộ
BAMOS project: osteochondral scaffold innovation applied to osteoarthritis
In vitro models - - 2022
Mario Monzón, Ricardo Donate, Chaozong Liu, Maryam Tamaddon, Joaquim M. Oliveira
In situ 3D spatiotemporal measurement of soluble biomarkers in spheroid culture
In vitro models - Tập 1 Số 4 - Trang 309-321 - 2022
McGhee, Alexander J., McGhee, Eric O., Famiglietti, Jack E., Sawyer, W. Gregory
Advanced cell culture techniques such as 3D bioprinting and hydrogel-based cell embedding techniques harbor many new and exciting opportunities to study cells in environments that closely recapitulate in vivo conditions. Researchers often study these environments using fluorescence microscopy to visualize the protein association with objects such as cells within the 3D environment, yet quantificat...... hiện toàn bộ
Modelling neurodegeneration and inflammation in early diabetic retinopathy using 3D human retinal organoids
In vitro models - Tập 3 Số 1 - Trang 33-48
Luisa de Lemos, Pedro Antas, Inês S. Ferreira, Inês Paz Santos, Beatriz Felgueiras, Catarina M. Gomes, Catarina Brito, Sandra Tenreiro
Abstract Purpose Diabetic retinopathy (DR) is a complication of diabetes and a primary cause of visual impairment amongst working-age individuals. DR is a degenerative condition in which hyperglycaemia results in morphological and functional changes in certain retinal cells. Existing treatments main...... hiện toàn bộ
Complex in vitro models: do not complicate it
In vitro models - Tập 2 - Trang 67-68 - 2023
J. Miguel Oliveira
Cơ chế gãy và tính chất cơ học của các thanh composite sandwich HA/PLCL và HA/PLLA xốp Dịch bởi AI
In vitro models - Tập 2 - Trang 207-218 - 2023
Fatin Hazwani, Aiman Izmin, Mitsugu Todo
Trước đây, chúng tôi đã phát triển một loại thanh sandwich composite xốp hydroxyapatite/poly L-lactic-co-caprolactone (HA/PLCL) mới như một loại vật liệu khung mới cho việc tái tạo xương. Công trình này trình bày việc nghiên cứu cơ chế gãy uốn và vi hư hại của thanh composite sandwich hydroxyapatite/poly L-lactic-acid (HA/PLLA), so với thanh sandwich HA/PLCL đã phát triển trước đó. Cả hai thanh đề...... hiện toàn bộ
#HA/PLCL #HA/PLLA #vi hư hại #cơ chế gãy #tính chất cơ học #composite xốp #tái tạo xương
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