Immunology
SCOPUS (1958-2023)SCIE-ISI
0019-2805
1365-2567
Anh Quốc
Cơ quản chủ quản: Wiley-Blackwell Publishing Ltd , WILEY
Lĩnh vực:
Immunology and AllergyImmunology
Các bài báo tiêu biểu
Inflammation in neurodegenerative diseasesSummary Neurodegeneration, the slow and progressive dysfunction and loss of neurons and axons in the central nervous system, is the primary pathological feature of acute and chronic neurodegenerative conditions such as Alzheimer’s disease and Parkinson’s disease, neurotropic viral infections, stroke, paraneoplastic disorders, traumatic brain injury and multiple scler...
Tập 129 Số 2 - Trang 154-169 - 2010
Signal transduction by the lipopolysaccharide receptor, Toll‐like receptor‐4Summary An understanding of lipopolysaccharide (LPS) signal transduction is a key goal in the effort to provide a molecular basis for the lethal effect of LPS during septic shock and point the way to novel therapies. Rapid progress in this field during the last 6 years has resulted in the discovery of not only the receptor for LPS – Toll‐like receptor 4 (TLR4) – but... ... hiện toàn bộ
Tập 113 Số 2 - Trang 153-162 - 2004
Cancer immunoediting from immune surveillance to immune escapeSummary Cancer immune surveillance is considered to be an important host protection process to inhibit carcinogenesis and to maintain cellular homeostasis. In the interaction of host and tumour cells, three essential phases have been proposed: elimination, equilibrium and escape, which are designated the ‘three E’s'. Several immune effector cells and secreted cytoki... ... hiện toàn bộ
Tập 121 Số 1 - Trang 1-14 - 2007
Immunosenescence: emerging challenges for an ageing populationSummary It is now becoming apparent that the immune system undergoes age‐associated alterations, which accumulate to produce a progressive deterioration in the ability to respond to infections and to develop immunity after vaccination, both of which are associated with a higher mortality rate in the elderly. Immunosenescence, defined as the changes in the immune sys... ... hiện toàn bộ
Tập 120 Số 4 - Trang 435-446 - 2007
CD56bright natural killer (NK) cells: an important NK cell subsetSummary Human natural killer (NK) cells can be subdivided into different populations based on the relative expression of the surface markers CD16 and CD56. The two major subsets are CD56bright CD16dim/ − and CD56dim CD16+ , respectively. In this review, we will foc... ... hiện toàn bộ
Tập 126 Số 4 - Trang 458-465 - 2009
Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T‐cell subsetSummary CD4+ CD25+ T regulatory cells (TReg ), suppress antigen‐specific immune responses and are important for allograft tolerance. During pregnancy the mother tolerates an allograft expressing paternal antigens (the fetus) requiring substantial changes in immune regulation over a programmed period of ti... ... hiện toàn bộ
Tập 112 Số 1 - Trang 38-43 - 2004
Intestinal colonization resistanceSummary Dense, complex microbial communities, collectively termed the microbiota, occupy a diverse array of niches along the length of the mammalian intestinal tract. During health and in the absence of antibiotic exposure the microbiota can effectively inhibit colonization and overgrowth by invading microbes such as pathogens. This phenomenon is called ‘colonizatio... ... hiện toàn bộ
Tập 138 Số 1 - Trang 1-11 - 2013
Nitric oxide in inflammatory bowel disease: a universal messenger in an unsolved puzzleSummary In recent years, nitric oxide (NO), a gas previously considered to be a potentially toxic chemical, has been established as a diffusible universal messenger that mediates cell–cell communication throughout the body. Constitutive and inducible NO production regulate numerous essential functions of the gastrointestinal mucosa, such as maintenance of adequate p... ... hiện toàn bộ
Tập 113 Số 4 - Trang 427-437 - 2004
IgG4 breaking the rulesSummary Immunoglobulin G4 (IgG4) antibodies have been known for some time to be functionally monovalent. Recently, the structural basis for this monovalency has been elucidated: the in vivo exchange of IgG half‐molecules (one H‐plus one L‐chain) among IgG4. This process results in bispecific antibodies that in most situations will behave a... ... hiện toàn bộ
Tập 105 Số 1 - Trang 9-19 - 2002
Tryptophan deprivation sensitizes activated T cells to apoptosis prior to cell divisionSummary Cells expressing indoleamine 2,3‐dioxygenase (IDO), an enzyme which catabolizes tryptophan, prevent T‐cell proliferation in vitro , suppress maternal antifetal immunity during pregnancy and inhibit T‐cell‐mediated responses to tumour‐associated antigens. To examine the mechanistic basis of these phenomena we activated naïve murine T... ... hiện toàn bộ
Tập 107 Số 4 - Trang 452-460 - 2002