Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T‐cell subset

Immunology - Tập 112 Số 1 - Trang 38-43 - 2004
David Somerset1, Yong Zheng2, Mark D. Kilby3, David M. Sansom2, Mark T. Drayson4
1Department of Fetal Medicine, Division of Reproduction and Child Health, University of Birmingham, Birmingham Women's Hospital, Birmingham, United Kingdom.
2MRC Center for Immune Regulation, University of Birmingham.
3Department of Fetal Medicine, Division of Reproduction and Child Health, University of Birmingham, Birmingham Women's Hospital
4Department of Immunology, Division of Immunity and Infection, University of Birmingham, United Kingdom

Tóm tắt

SummaryCD4+ CD25+ T regulatory cells (TReg), suppress antigen‐specific immune responses and are important for allograft tolerance. During pregnancy the mother tolerates an allograft expressing paternal antigens (the fetus) requiring substantial changes in immune regulation over a programmed period of time. We analysed whether immune‐suppressive TReg cells were altered during pregnancy and therefore might play a part in this tolerant state. The presence of TReg cells was assessed in the blood of 25 non‐pregnant, 63 pregnant and seven postnatal healthy women by flow cytometry. We observed an increase in circulating TReg cells during early pregnancy, peaking during the second trimester and then a decline postpartum. Isolated CD25+ CD4+ cells expressed FoxP3 messenger RNA, a marker of TReg cells, and suppressed proliferative responses of autologous CD4+ CD25– T cells to allogeneic dendritic cells. These data support the concept that normal pregnancy is associated with an elevation in the number of TReg cells which may be important in maintaining materno‐fetal tolerance.

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Immunology

Tập 112 Số 1

38-43

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