Immunology

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Effect of mucosal and systemic immunization with virus‐like particles of severe acute respiratory syndrome coronavirus in mice
Immunology - Tập 130 Số 2 - Trang 254-261 - 2010
Baojing Lu, Yi Huang, Li Huang, Li Bao, Zhenhua Zheng, Ze Chen, Jianjun Chen, Qinxue Hu, Sheng Wang
SummaryNasal administration has emerged as a promising and attractive route for vaccination, especially for the prophylaxis of respiratory diseases. Our previous studies have shown that severe acute respiratory syndrome coronavirus (SARS‐CoV) virus‐like particles (VLPs) can be assembled using a recombinant baculovirus (rBV) expression system and such VLPs induce sp...... hiện toàn bộ
Role of prolactin in the in vitro development of interleukin‐2‐driven anti‐tumoural lymphokine‐activated killer cells
Immunology - Tập 89 Số 4 - Trang 619-626 - 1996
Lina Matera, Graziella Bellone, Jean‐Jacques Lebrun, Paul A. Kelly, Elisabeth Peters, Paola Francia di Celle, Robin Foà, M Contarini, Gian Carlo Avanzi, Veronica Asnaghi
Exogenous prolactin (PRL) has been shown to synergize with low‐dose interleukin‐2 (IL‐2) and induce the proliferation and lymphokine‐activated killer (LAK) maturation of natural killer (NK) cells. PRL itself can also generate LAK activity. Here we show that its local production occurs during, and is necessary for, LAK development. IL‐2‐stimulated peripheral blood mononuclear cells (PBMC) a...... hiện toàn bộ
Up‐modulation of interferon‐γ mediates the enhancement of spontanous cytotoxicity in prolactin‐activated natural killer cells
Immunology - Tập 98 Số 3 - Trang 386-392 - 1999
Lina Matera, M. Contarini, Graziella Bellone, B Forno, A Biglino
SummaryProlactin (PRL) has been shown to participate in lymphocyte activation. In particular, the constitutive natural killer (NK) and the lymphokine‐activated killer (LAK) cytotoxicity of CD56+ CD16+ cells is increased by its physiological to supraphysiological concentrations. As PRL has been shown to up‐regulate the produ...... hiện toàn bộ
Reversal of functional defects in highly differentiated young and old CD8 T cells by PDL blockade
Immunology - Tập 135 Số 4 - Trang 355-363 - 2012
Siân M. Henson, R. Macaulay, Ornella Franzese, Arne N. Akbar
SummaryHighly differentiated CD8+ CD28− CD27− T cells have short telomeres, defective telomerase activity and reduced capacity for proliferation. In addition, these cells express increased levels of inhibitory receptors and display defective Akt(ser473) phosphorylation following act...... hiện toàn bộ
HCV‐specific CD27− CD28− memory T cells are depleted in hepatitis C virus and Schistosoma mansoni co‐infection
Immunology - Tập 110 Số 4 - Trang 513-518 - 2003
Mohamed F. El‐Refaei, Nabila El-Sheikh, Karim Kamal, Huyen Cao
SummaryFactors that influence the generation and maintenance of memory CD8+ T cells are not fully understood. The homeostasis of memory T cells is highly dynamic and tightly regulated by various stimuli, including cytokines and antigen–major histocompatibility complex ligands. We characterized the hepatitis C virus (HCV)‐specific CD8+...... hiện toàn bộ
The aryl hydrocarbon receptor: a perspective on potential roles in the immune system
Immunology - Tập 127 Số 3 - Trang 299-311 - 2009
Emily A. Stevens, Joshua D. Mezrich, Christopher A. Bradfield
SummaryThe aryl hydrocarbon receptor (AHR) is a protein best known for its role in mediating toxicity. Over 30 years of research has uncovered additional roles for the AHR in xenobiotic metabolism and normal vascular development. Activation of the AHR has long been known to cause immunotoxicity, including thymic involution. Recent data suggesting a role for the AHR...... hiện toàn bộ
Tryptophan deprivation sensitizes activated T cells to apoptosis prior to cell division
Immunology - Tập 107 Số 4 - Trang 452-460 - 2002
Geon Kook Lee, Hyeon Jin Park, Megan K. L. MacLeod, Phillip Chandler, David H. Munn, Andrew L. Mellor
SummaryCells expressing indoleamine 2,3‐dioxygenase (IDO), an enzyme which catabolizes tryptophan, prevent T‐cell proliferation in vitro, suppress maternal antifetal immunity during pregnancy and inhibit T‐cell‐mediated responses to tumour‐associated antigens. To examine the mechanistic basis of these phenomena we activated naïve murine T...... hiện toàn bộ
Cancer immunoediting from immune surveillance to immune escape
Immunology - Tập 121 Số 1 - Trang 1-14 - 2007
Ryungsa Kim, Manabu Emi, Kazuaki Tanabe
SummaryCancer immune surveillance is considered to be an important host protection process to inhibit carcinogenesis and to maintain cellular homeostasis. In the interaction of host and tumour cells, three essential phases have been proposed: elimination, equilibrium and escape, which are designated the ‘three E’s'. Several immune effector cells and secreted cytoki...... hiện toàn bộ
Studies on transcriptional regulation of the mucosal T‐cell integrin αEβ7 (CD103)
Immunology - Tập 103 Số 2 - Trang 146-154 - 2001
Paul Robinson, Sally J. Green, Christine Carter, John Coadwell, Peter J. Kilshaw
SummaryIntegrin αEβ7 is expressed almost exclusively by mucosal T cells and mucosal dendritic antigen‐presenting cells (APCs) and is thought to be induced locally by transforming growth factor‐β (TGF‐β). In mice, mRNA for the αE subunit was found to be abundant in mucosal T cells but absent from other tissues. Exposure of a T‐cell line to TGF‐β strongly up‐regulate...... hiện toàn bộ
Mechanisms of binding of cutaneous lymphocyte‐associated antigen‐positive and αeβ7‐positive lymphocytes to oral and skin keratinocytes
Immunology - Tập 98 Số 1 - Trang 9-15 - 1999
Todd M. Brown, Thomas A. Furness, Speight, Thomas Ns, Chi Kong Li, Martin H. Thornhill, Farthing
Intraepithelial lymphocytes (IEL) utilize the integrin αeβ7 on their surface to bind to E‐cadherin on epithelial cells in the gut and breast. In oral mucosa and skin IEL express αeβ7 and the cutaneous lymphocyte‐associated antigen (CLA) but the mechanisms of adhesion of these subsets to keratinocytes are unknown. Levels of αeβ7 and CLA were up‐regulated on peripheral blood lymphocytes (PBL...... hiện toàn bộ
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