Immunology

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Antigen processing and CD24 expression determine antigen presentation by splenic CD4+ and CD8+ dendritic cells
Immunology - Tập 123 Số 3 - Trang 447-455 - 2008
David Askew, Clifford V. Harding
SummaryTo examine heterogeneity in dendritic cell (DC) antigen presentation function, murine splenic DCs were separated into CD4+ and CD8+ populations and assessed for the ability to process and present particulate antigen to CD4+ and CD8+ T cells. CD4+ and CD8<...... hiện toàn bộ
Mesenteric lymph node CD11b− CD103+ PD‐L1High dendritic cells highly induce regulatory T cells
Immunology - Tập 152 Số 1 - Trang 52-64 - 2017
Aya Shiokawa, Ryutaro Kotaki, Tomohiro Takano, Haruyo Nakajima‐Adachi, Satoshi Hachimura
SummaryDendritic cells (DCs) in mesenteric lymph nodes (MLNs) induce Foxp3+ regulatory T cells to regulate immune responses to beneficial or non‐harmful agents in the intestine, such as commensal bacteria and foods. Several studies in MLN DCs have revealed that the CD103+ DC subset highly induces regulatory T cells, and ano...... hiện toàn bộ
Reversal of functional defects in highly differentiated young and old CD8 T cells by PDL blockade
Immunology - Tập 135 Số 4 - Trang 355-363 - 2012
Siân M. Henson, R. Macaulay, Ornella Franzese, Arne N. Akbar
SummaryHighly differentiated CD8+ CD28− CD27− T cells have short telomeres, defective telomerase activity and reduced capacity for proliferation. In addition, these cells express increased levels of inhibitory receptors and display defective Akt(ser473) phosphorylation following act...... hiện toàn bộ
Immunogenetics as a tool in anthropological studies
Immunology - Tập 133 Số 2 - Trang 143-164 - 2011
Alicia Sanchez‐Mazas, Marcelo Fernández-Viña, Derek Middleton, Jill A. Hollenbach, Stéphane Bühler, Da Di, Raja Rajalingam, Jean‐Michel Dugoujon, Steven J. Mack, Erik Thorsby
Release of preformed Fas ligand in soluble form is the major factor for activation‐induced death of Jurkat T cells
Immunology - Tập 89 Số 4 - Trang 511-517 - 1996
Marı́a José Martı́nez-Lorenzo, M.A. Álava, Alberto Anel, Andrés Piñeiro, Javier Naval
Interaction of Fas/APO‐1 (CD95) and its ligand (FasL) plays an important role in the activation‐induced cell death (AICD) of T lymphocytes. In the present work, the contribution of soluble FasL to AICD of the human T‐cell line Jurkat has been studied. Jurkat cells prestimulated with phytohaemagglutinin (PHA) induced the death of non‐activated Jurkat cells, and also of L1210Fas, but not tha...... hiện toàn bộ
The role of the macrophage scavenger receptor in immune stimulation by bacterial DNA and synthetic oligonucleotides
Immunology - Tập 103 Số 2 - Trang 226-234 - 2001
Fu‐Gang Zhu, Charles F. Reich, David S. Pisetsky
SummaryTo assess the role of the macrophage scavenger receptor type A (SRA) in immune activation by CpG DNA, cytokine induction and DNA uptake were tested in vitro and in vivo using SRA knockout (SRA−/−) and wild type (WT) mice. As a source of CpG DNA, Escherichia coli... hiện toàn bộ
Investigation of the mechanism of action of alemtuzumab in a human CD52 transgenic mouse model
Immunology - Tập 128 Số 2 - Trang 260-270 - 2009
Yanping Hu, Michael J. Turner, Jacqueline D. Shields, Matthew Gale, Elizabeth Hutto, Bruce Roberts, William Siders, Johanne Kaplan
SummaryAlemtuzumab is a humanized monoclonal antibody against CD52, an antigen found on the surface of normal and malignant lymphocytes. It is approved for the treatment of B‐cell chronic lymphocytic leukaemia and is undergoing Phase III clinical trials for the treatment of multiple sclerosis. The exact mechanism by which alemtuzumab mediates its biological effects...... hiện toàn bộ
Functional analysis of a tripartite stability element within the CD40 ligand 3′ untranslated region
Immunology - Tập 124 Số 3 - Trang 368-379 - 2008
Jennifer Laughlin, Sanaz Oghlidos, Joseph F. Porter, Rodrigo Matus‐Nicodemos, Frank L. Sinquett, Valentina Marcelli, Lori R. Covey
SummaryWe previously identified a cis‐acting element within the 3′ untranslated region of CD40 ligand messenger RNA (mRNA) that is composed of three complex binding sites and acts to increase mRNA stability in both in vitro and in vivo systems. We now demonstrate the functional consequ...... hiện toàn bộ
Histamine and prostaglandin E2 up‐regulate the production of Th2‐attracting chemokines (CCL17 and CCL22) and down‐regulate IFN‐γ‐induced CXCL10 production by immature human dendritic cells
Immunology - Tập 117 Số 4 - Trang 507-516 - 2006
Anne McIlroy, Gersende Caron, Simon Blanchard, Isabelle Frémaux, Dorothée Duluc, Yves Delneste, Alain Chevailler, Pascale Jeannin
SummaryEffector memory T helper 2 (Th2) cells that accumulate in target organs (i.e. skin or bronchial mucosa) have a central role in the pathogenesis of allergic disorders. To date, the factors that selectively trigger local production of Th2‐attracting chemokines remain poorly understood. In mucosa, at the sites of allergen entry, immature dendritic cells (DC) ar...... hiện toàn bộ
Toll‐like receptor interactions: tolerance of MyD88‐dependent cytokines but enhancement of MyD88‐independent interferon‐β production
Immunology - Tập 120 Số 1 - Trang 103-111 - 2007
Andrea Broad, John A. Kirby, David Jones
SummaryToll‐like receptors (TLRs) signal through two main pathways: a myeloid differentiation factor (MyD)88‐dependent pathway that acts via nuclear factor κB (NF‐κB) to induce proinflammatory cytokines such as tumour necrosis factor‐α (TNF‐α) and a MyD88‐independent pathway that acts via type I interferons to increase the expression of interferon‐inducible genes. ...... hiện toàn bộ
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