Immunology

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Anti‐interleukin‐33 inhibits cigarette smoke‐induced lung inflammation in mice
Immunology - Tập 138 Số 1 - Trang 76-82 - 2013
Chuan Qiu, Yan Li, Mingcai Li, Min Li, Xiaojin Liu, Charles McSharry, Damo Xu
SummaryThe mechanism by which cigarette smoke (CS) causes chronic obstructive pulmonary disease (COPD) is poorly understood. Interleukin‐33 (IL‐33) is a pleiotropic cytokine predomi...... hiện toàn bộ
Inflammation in neurodegenerative diseases
Immunology - Tập 129 Số 2 - Trang 154-169 - 2010
Sandra Amor, Fabìola Puentes, David Baker, Paul van der Valk
Summary Neurodegeneration, the slow and progressive dysfunction and loss of neurons and axons in the central nervous system, is the primary pathological feature of acute and chronic neurodegenerative conditions such as Alzheimer’s disease and Parkinson’s disease, neurotropic viral infections, stroke, paraneoplastic disorders, traumatic brain injury and multiple scler...... hiện toàn bộ
CD56bright natural killer (NK) cells: an important NK cell subset
Immunology - Tập 126 Số 4 - Trang 458-465 - 2009
Aurélie Poli, Tatiana Michel, Maud Thérésine, Emmanuel Andrès, François Hentges, Jacques Zimmer
SummaryHuman natural killer (NK) cells can be subdivided into different populations based on the relative expression of the surface markers CD16 and CD56. The two major subsets are CD56bright CD16dim/− and CD56dim CD16+, respectively. In this review, we will foc...... hiện toàn bộ
Targeting glycolysis in Th2 cells by pterostilbene attenuates clinical severities in an asthmatic mouse model and IL‐4 production in peripheral blood from asthmatic patients
Immunology - Tập 166 Số 2 - Trang 222-237 - 2022
Chuan‐Teng Liu, Ying Song, Ting Wu, Ko‐Chieh Shiung, I‐Hsuan Chen, Tung‐Ti Chang, Shinn‐Jye Liang, Hung‐Rong Yen
AbstractAsthma, a major non‐communicable disease, affects both adults and children and is associated with high morbidity compared with other chronic diseases. The glycolysis‐associated activation of type 2 helper T (Th2) cells is the critical immunopathological mechanism involved in asthma deterioration. Long‐term use of steroids as a medical treatment for asthma i...... hiện toàn bộ
Characterization of chicken epidermal dendritic cells
Immunology - Tập 119 Số 2 - Trang 278-288 - 2006
Botond Z. Igyártó, Erzsébet Lackó, Imre Oláh, Attila Magyar
SummaryIt has been known for 15 years that the chicken epidermis contains ATPase+ and major histocompatibility complex class II‐positive (MHCII+) dendritic cells. These cells were designated as Langerhans cells but neither their detailed phenotype nor their function was further investigated. In the present paper we demonstr...... hiện toàn bộ
Role of mRNA stability in the different patterns of cytokine production by CD4+ cells from young and old mice
Immunology - Tập 94 Số 3 - Trang 380-387 - 1998
Claudio Pioli, Sabina Pucci, Simona Barile, Daniela Frasca, G Doria
CD4+ cells from young (3 months) and old (19 months) mice were stimulated by plate‐bound anti‐CD3 monoclonal antibody (mAb) alone or also by soluble anti‐CD28 mAb. Supernatants were analysed by enzyme‐linked immunosorbent assay (ELISA) to determine cytokine concentrations. Total RNA was extracted from cells, reverse transcribed and the cDNA amplified by polymerase chai...... hiện toàn bộ
Dietary lipids modify the cytokine response to bacterial lipopolysaccharide in mice
Immunology - Tập 96 Số 3 - Trang 404-410 - 1999
Mohammad Reza Sadeghi, Fiona Wallace, Philip C. Calder
To investigate the effect of dietary lipids with different fatty acid compositions upon the in vivo cytokine response to bacterial lipopolysaccharide (LPS), mice were fed for 5 weeks on a low‐fat diet or on one of four high‐fat diets that contained 20%, by weight, of coconut oil (CO), olive oil (OO), safflower oil (SO) or fish oil (FO). The mice were injected int...... hiện toàn bộ
Isoproterenol regulates tumour necrosis factor, interleukin‐10, interleukin‐6 and nitric oxide production and protects against the development of vascular hyporeactivity in endotoxaemia
Immunology - Tập 90 Số 1 - Trang 95-100 - 1997
Csaba Szabó, György Haskó, Basilia Zingarelli, Zoltán Németh, Andrew L. Salzman, Vladimír Kvetan, Stephen M. Pastores, E. Sylvester Vizi
Pro‐inflammatory cytokines, such as tumour necrosis factor (TNF) and free radicals, such as nitric oxide (NO), are mediators of endotoxaemia. Catecholamines are in clinical use to treat the haemodynamic consequences of severe septic shock. Beta‐adrenergic agonists exert many of their effects by elevation of intracellular cyclic AMP (cAMP) concentration. Cyclic AMP can modulate endotoxin‐in...... hiện toàn bộ
Toll‐like receptor 3 in viral pathogenesis: friend or foe?
Immunology - Tập 140 Số 2 - Trang 153-167 - 2013
Renzo Perales‐Linares, Sonia Navas
SummaryViral infections frequently induce acute and chronic inflammatory diseases, yet the contribution of the innate immune response to a detrimental host response remains poorly understood. In virus‐infected cells, double‐stranded RNA (dsRNA...... hiện toàn bộ
Inhibitors of dipeptidyl peptidase IV induce secretion of transforming growth factor‐β1 in PWM‐stimulated PBMC and T cells
Immunology - Tập 91 Số 3 - Trang 354-360 - 1997
Dirk Reinhold, Ute Bank, Frank Bühling, Uwe Lendeckel, Jürgen Faust, Klaus Neubert, Siegfried Ansorge
Various studies have shown that the membrane ectoenzyme dipeptidyl peptidase IV (DPIV; CD26), expressed on T, natural killer (NK) and B cells in the immune system, is involved in the regulation of DNA synthesis and cytokine production. We show that the specific DP IV inhibitors Lys[ Z(NO2)]‐thiazolidide, Lys[Z(NO2)]‐piperidide, and Lys[Z(NO... hiện toàn bộ
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