Human Molecular Genetics
1460-2083
0964-6906
Anh Quốc
Cơ quản chủ quản: Oxford University Press , OXFORD UNIV PRESS
Lĩnh vực:
Genetics (clinical)Medicine (miscellaneous)GeneticsMolecular Biology
Các bài báo tiêu biểu
Mendelian randomization: genetic anchors for causal inference in epidemiological studies
Tập 23 Số R1 - Trang R89-R98 - 2014
Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases
Tập 18 Số R2 - Trang R169-R176 - 2009
Genetic basis for individual variations in pain perception and the development of a chronic pain condition
Tập 14 Số 1 - Trang 135-143 - 2005
Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy
Tập 11 Số 9 - Trang 1107-1117 - 2002
TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration
Tập 19 Số R1 - Trang R46-R64 - 2010
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry Abstract
More than one in three adults worldwide is either overweight or obese. Epidemiological studies indicate that the location and distribution of excess fat, rather than general adiposity, are more informative for predicting risk of obesity sequelae, including cardiometabolic disease and cancer. We performed a genome-wide association study meta-analysis of body fat distribution, measured by waist-to-hip ratio (WHR) adjusted for body mass index (WHRadjBMI), and identified 463 signals in 346 loci. Heritability and variant effects were generally stronger in women than men, and we found approximately one-third of all signals to be sexually dimorphic. The 5% of individuals carrying the most WHRadjBMI-increasing alleles were 1.62 times more likely than the bottom 5% to have a WHR above the thresholds used for metabolic syndrome. These data, made publicly available, will inform the biology of body fat distribution and its relationship with disease.
Tập 28 Số 1 - Trang 166-174 - 2019