Genetic basis for individual variations in pain perception and the development of a chronic pain condition

Mogil, J.S. ( 1999 ) The genetic mediation of individual differences in sensitivity to pain and its inhibition. Proc. Natl Acad. Sci. USA , 96 , 7744 –7751.

Mogil, J.S., Wilson, S.G., Chesler, E.J., Rankin, A.L., Nemmani, K.V., Lariviere, W.R., Groce, M.K., Wallace, M.R., Kaplan, L., Staud, R. et al. ( 2003 ) The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans. Proc. Natl Acad. Sci. USA , 100 , 4867 –4872.

Nagasako, E.M., Oaklander, A.L. and Dworkin, R.H. ( 2003 ) Congenital insensitivity to pain: an update. Pain , 101 , 213 –219.

Zubieta, J.K., Heitzeg, M.M., Smith, Y.R., Bueller, J.A., Xu, K., Xu, Y., Koeppe, R.A., Stohler, C.S. and Goldman, D. ( 2003 ) COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor. Science , 299 , 1240 –1243.

Mannisto, P.T. and Kaakkola, S. ( 1999 ) Catechol- O -methyltransferase (COMT): biochemistry, molecular biology, pharmacology and clinical efficacy of the new selective COMT inhibitors. Pharmacol. Rev. , 51 , 593 –628.

National Ambulatory Medical Care Survey, Report of the Panel on Communicative Disorders and Stroke Council. No: 81-1914. 6-1-1979. Public Health Service, NIH, Washington, D.C.

John, M.T., Miglioretti, D.L., LeResche, L., Von Korff, M. and Critchlow, C.W. ( 2003 ) Widespread pain as a risk factor for dysfunctional temporomandibular disorder pain. Pain , 102 , 257 –263.

Von Korff, M., Le Resche, L. and Dworkin, S.F. ( 1993 ) First onset of common pain symptoms: a prospective study of depression as a risk factor. Pain , 55 , 251 –258.

Maixner, W., Fillingim, R., Booker, D. and Sigurdsson, A. ( 1995 ) Sensitivity of patients with painful temporomandibular disorders to experimentally evoked pain. Pain , 63 , 341 –351.

Maixner, W., Fillingim, R., Sigurdsson, A., Kincaid, S. and Silva, S. ( 1998 ) Sensitivity of patients with painful temporomandibular disorders to experimentally evoked pain: evidence for altered temporal summation of pain. Pain , 76 , 71 –81.

Marbach, J.J. and Levitt, M. ( 1976 ) Erythrocyte catechol- O -methyltransferase activity in facial pain patients. J. Dent. Res. , 55 , 711 .

Dworkin, S.F., Fricton, J.R., Hollender, L., Huggins, K.H., LeResche, L., Lund, J., Mohl, N., Ohrbach, R., Palla, S.F., Sommers, E.E. et al. ( 1992 ) Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique. J. Craniomandibular Disord. Facial Pain Oral Pain , 6 , 302 –355.

Carlsson, G.E. and Le Resche, L. ( 1995 ) In Sessle, B.J., Bryant, P.S. and Dionne, R.A. (eds), Temporomandibular Disorders and Related Pain Conditions . IASP Press, Seattle, Vol. 4 , pp. 211 –226.

Yu, X.-M., Hua, M. and Mense, S. ( 1991 ) The effects of intracerebroventricular injection of naloxone, phentolamine, methysergide on the transmission of nociceptive signals in the rat dorsal horn neurones with convergent cutaneous-deep input. Neuroscience , 44 , 715 –723.

Mense, S. ( 1993 ) Nociception from skeletal muscle in relation to clinical muscle pain. Pain , 54 , 241 –289.

Xie, T., Ho, S.L. and Ramsden, D. ( 1999 ) Characterization and implications of estrogenic down-regulation of human catechol- O -methyltransferase gene transcription. Mol. Pharmacol. , 56 , 31 –38.

DeMille, M.M., Kidd, J.R., Ruggeri, V., Palmatier, M.A., Goldman, D., Odunsi, A., Okonofua, F., Grigorenko, E., Schulz, L.O., Bonne-Tamir, B. et al. ( 2002 ) Population variation in linkage disequilibrium across the COMT gene considering promoter region and coding region variation. Hum. Genet. , 111 , 521 –537.

Shifman, S., Bronstein, M., Sternfeld, M., Pisante-Shalom, A., Lev-Lehman, E., Weizman, A., Reznik, I., Spivak, B., Grisaru, N., Karp, L. et al. ( 2002 ) A highly significant association between a COMT haplotype and schizophrenia. Am. J. Hum. Genet. , 71 , 1296 –1302.

Li, T., Ball, D., Zhao, J., Murray, R.M., Liu, X., Sham, P.C. and Collier, D.A. ( 2000 ) Family-based linkage disequilibrium mapping using SNP marker haplotypes: application to a potential locus for schizophrenia at chromosome 22q11. Mol. Psychiatry , 5 , 452 .

Risch, N.J. ( 2000 ) Searching for genetic determinants in the new millennium. Nature , 405 , 847 –856.

Gabriel, S.B., Schaffner, S.F., Nguyen, H., Moore, J.M., Roy, J., Blumenstiel, B., Higgins, J., DeFelice, M., Lochner, A., Faggart, M. et al. ( 2002 ) The structure of haplotype blocks in the human genome. Science , 296 , 2225 –2229.

Lotta, T., Vidgren, J., Tilgmann, C., Ulmanen, I., Melen, K., Julkunen, I. and Taskinen, J. ( 1995 ) Kinetics of human soluble and membrane-bound catechol O -methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry , 34 , 4202 –4210.

Azzam, A. and Mathews, C.A. ( 2003 ) Meta-analysis of the association between the catecholamine- O -methyl-transferase gene and obsessive-compulsive disorder. Am. J. Med. Genet. , 123B , 64 –69.

Glatt, S.J., Faraone, S.V. and Tsuang, M.T. ( 2003 ) Association between a functional catechol O -methyltransferase gene polymorphism and schizophrenia: meta-analysis of case–control and family-based studies. Am. J. Psychiatry , 160 , 469 –476.

Duan, J., Wainwright, M.S., Comeron, J.M., Saitou, N., Sanders, A.R., Gelernter, J. and Gejman, P.V. ( 2003 ) Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. Hum. Mol. Genet. , 12 , 205 –216.

Abiola, O., Angel, J.M., Avner, P., Bachmanov, A.A., Belknap, J.K., Bennett, B., Blankenhorn, E.P., Blizard, D.A., Bolivar, V., Brockmann, G.A. et al. ( 2003 ) The nature and identification of quantitative trait loci: a community's view. Nat. Rev. Genet. , 4 , 911 –916.

Drysdale, C.M., McGraw, D.W., Stack, C.B., Stephens, J.C., Judson, R.S., Nandabalan, K., Arnold, K., Ruano, G. and Liggett, S.B. ( 2000 ) Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proc. Natl Acad. Sci. USA , 97 , 10483 –10488.

Bray, N.J., Buckland, P.R., Williams, N.M., Williams, H.J., Norton, N., Owen, M.J. and O'Donovan, M.C. ( 2003 ) A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain. Am. J. Hum. Genet. , 73 , 152 –161.

Davidson, S. ( 2000 ) Research suggests importance of haplotypes over SNPs. Nat. Biotechnol. , 18 , 1134 –1135.

Khasar, S.G., Green, P.G., Miao, F.J. and Levine, J.D. ( 2003 ) Vagal modulation of nociception is mediated by adrenomedullary epinephrine in the rat. Eur. J. Neurosci. , 17 , 909 –915.

Jaeger, B. and Reeves, J.L. ( 1986 ) Quantification of changes in myofascial trigger point sensitivity with the pressure algometer following passive stretch. Pain , 27 , 203 –210.

Fruhstorfer, H., Lindblom, U. and Schmidt, W.G. ( 1976 ) Method for quantitative estimation of thermal thresholds in patients. J. Neurol. Neurosurg. Psychiatry , 39 , 1071 –1075.

Price, D.D., Hu, J.W., Dubner, R. and Gracely, R.H. ( 1977 ) Peripheral suppression of first pain and central summation of second pain evoked by noxious heat pulses. Pain , 3 , 57 –68.

Vierck, C.J., Jr, Cannon, R.L., Fry, G., Maixner, W. and Whitsel, B.L. ( 1997 ) Characteristics of temporal summation of second pain sensations elicited by brief contact of glabrous skin by a preheated thermode. J. Neurophysiol. , 78 , 992 –1002.

Shi, M.M., Bleavins, M.R. and de la Iglesia, F.A. ( 1999 ) Technologies for detecting genetic polymorphisms in pharmacogenomics. Mol. Diagn. , 4 , 343 –351.

Shagin, D.A., Rebrikov, D.V., Kozhemyako, V.B., Altshuler, I.M., Shcheglov, A.S., Zhulidov, P.A., Bogdanova, E.A., Staroverov, D.B., Rasskazov, V.A. and Lukyanov, S. ( 2002 ) A novel method for SNP detection using a new duplex-specific nuclease from crab hepatopancreas. Genome Res. , 12 , 1935 –1942.

Masuda, M., Tsunoda, M., Yusa, Y., Yamada, S. and Imai, K. ( 2002 ) Assay of catechol- O -methyltransferase activity in human erythrocytes using norepinephrine as a natural substrate. Ann. Clin. Biochem. , 39 , 589 –594.

Chaplan, S.R., Pogrel, J.W. and Yaksh, T.L. ( 1994 ) Role of voltage-dependent calcium channel subtypes in experimental tactile allodynia. J. Pharmacol. Exp. Ther. , 269 , 1117 –1123.

Hargreaves, K., Dubner, R., Brown, F., Flores, C. and Joris, J. ( 1988 ) A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain , 32 , 77 –88.