Classification of colorectal cancer based on correlation of clinical, morphological and molecular features Tập 50 Số 1 - Trang 113-130 - 2007
J R Jass
Over the last 20 years it has become clear that colorectal cancer (CRC) evolves
through multiple pathways. These pathways may be defined on the basis of two
molecular features: (i) DNA microsatellite instability (MSI) status stratified
as MSI‐high (MSI‐H), MSI‐low (MSI‐L) and MS stable (MSS), and (ii) CpG island
methylator phenotype (CIMP) stratified as CIMP‐high, CIMP‐low and CIMP‐negative
(CIMP‐... hiện toàn bộ
Postmortem examination of COVID‐19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction Tập 77 Số 2 - Trang 198-209 - 2020
Thomas Menter, Jasmin D. Haslbauer, Ronny Nienhold, Spasenija Savic, Helmut Hopfer, Nikolaus Deigendesch, Stephan Frank, Daniel Turek, Niels Willi, Hans Pargger, Stefano Bassetti, Jörg D. Leuppi, Gieri Cathomas, Markus Tolnay, Kirsten D. Mertz, Alexandar Tzankov
AimsCoronavirus disease 2019 (COVID‐19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2), has rapidly evolved into a sweeping
pandemic. Its major manifestation is in the respiratory tract, and the general
extent of organ involvement and the microscopic changes in the lungs remain
insufficiently characterised. Autopsies are essential to elucidate
COVID‐19‐associated organ alt... hiện toàn bộ
Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases Tập 41 Số 1 - Trang 1-29 - 2002
Stefano Pileri, Thomas M. Grogan, Nancy L. Harris, Peter M. Banks, Elı́as Campo, John K. Chan, Riccardo Dalla Favera, Georges Delsol, Christiane De Wolf‐Peeters, Brunangelo Falini, R. D. Gascoyne, Philippe Gaulard, Kevin C. Gatter, Peter G. Isaacson, Elaine S. Jaffe, Philip M. Kluin, Daniel M. Knowles, Miguel Á. Piris, Shunsuke Mori, Hans Konrad Müller‐Hermelink, Elisabeth Ralfkiær, Harald Stein, Ih‐Jen Su, Roger A. Warnke, Lawrence M. Weiss
Tumours of histiocytes and accessory dendritic cells: an immunohistochemical
approach to classification from the International Lymphoma Study Group based on
61 cases Neoplasms of histiocytes and dendritic cells are rare, and their
phenotypic and biological definition is incomplete. Seeking to identify antigens
detectable in paraffin‐embedded sections that might allow a more complete,
rational immu... hiện toàn bộ
Synovitis score: discrimination between chronic low‐grade and high‐grade synovitis Tập 49 Số 4 - Trang 358-364 - 2006
Veit Krenn, Lars Morawietz, Gerd R Burmester, Raimund W. Kinne, Ulf Mueller‐Ladner, B Müller, Frank Buttgereit
Aims : To standardize the histopathological assessment of synovial membrane
specimens in order to contribute to the diagnostics of rheumatic and
non‐rheumatic joint diseases.Methods and results : Three features of chronic
synovitis (enlargement of lining cell layer, cellular density of synovial
stroma, leukocytic infiltrate) were semiquantitatively evaluated (from 0, absent
to 3, strong) and each ... hiện toàn bộ
Ki67 protein: the immaculate deception? Tập 40 Số 1 - Trang 2-11 - 2002
D C Brown, Kevin C. Gatter
Ki67 protein: the immaculate deception? This article updates our previous review
of Ki67 published in Histopathology 10 years ago. In this period the numbers of
papers published featuring this antibody has increased 10‐fold from 338 to 3489
indicating the considerable enthusiasm with which this antibody has been
studied. This review attempts to provide an update on the characterization of
the Ki67... hiện toàn bộ
Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease Tập 38 Số 2 - Trang 120-134 - 2001
M. R. D’Andrea, Robert G. Nagele, H‐Y Wang, Peter Højrup, D H S Lee
Aims:Amyloid has recently been shown to accumulate intracellularly in the brains
of patients with Alzheimer's disease (AD), yet amyloid plaques are generally
thought to arise from gradual extracellular amyloid deposition. We have
investigated the possibility of a link between these two apparently conflicting
observations.Methods and results:Immunohistochemistry and digital image analysis
was used ... hiện toàn bộ
Ultrastructure of airways in children with asthma Tập 2 Số 6 - Trang 407-421 - 1978
Ernest Cutz, Henry Levison, David M. L. Cooper
This study describes the histopathology and ultrastructure of bronchial mucosa
in lung biopsies from two children with bronchial asthma in remission, and
compares them with lung samples from two children who died in status
asthmaticus. Light microscopy of all samples showed changes typical of bronchial
asthma, e.g. mucus plugging, goblet cell hyperplasia, ‘thickening of bronchial
basement membrane... hiện toàn bộ