Histopathology
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Ki67 protein: the immaculate deception?
Histopathology - Tập 40 Số 1 - Trang 2-11 - 2002
Ki67 protein: the immaculate deception? This article updates our previous review
of Ki67 published in Histopathology 10 years ago. In this period the numbers of
papers published featuring this antibody has increased 10‐fold from 338 to 3489
indicating the considerable enthusiasm with which this antibody has been
studied. This review attempts to provide an update on the characterization of
the Ki67...
Synovitis score: discrimination between chronic low‐grade and high‐grade synovitis
Histopathology - Tập 49 Số 4 - Trang 358-364 - 2006
Aims : To standardize the histopathological assessment of synovial membrane
specimens in order to contribute to the diagnostics of rheumatic and
non‐rheumatic joint diseases.Methods and results : Three features of chronic
synovitis (enlargement of lining cell layer, cellular density of synovial
stroma, leukocytic infiltrate) were semiquantitatively evaluated (from 0, absent
to 3, strong) and each ...
Maintenance of polarity and a dual cell population in adenoid cystic carcinoma of the breast: an immunohistochemical study
Histopathology - Tập 32 Số 3 - Trang 232-238 - 1998
Aims:Adenoid cystic carcinoma (ACC) of the breast, although quite uncommon, is
histologically distinct and has an excellent prognosis. Our purpose was to
characterize molecular markers of cellular differentiation and polarity to
define better the role that these combined features might play in the excellent
prognosis of ACC in this site.Methods and results:We performed
immunohistochemical stains f...
High sensitivity and specificity of immunohistochemistry for the detection of hormone receptors in breast carcinoma: comparison with biochemical determination in a prospective study of 793 cases
Histopathology - Tập 37 Số 6 - Trang 536-545 - 2000
The hormone receptor (HR) status of breast cancer is an important prognostic
factor and predictive parameter of the response to hormone therapy. Enzyme
immunoassay (EIA) is currently the standard for determination of HR, but
immunohistochemistry (IHC) represents a potentially useful alternative. We used
IHC to determine HR status in a large prospective study and compared the results
to those obtai...
Adenoid cystic carcinoma of the breast: a case with axillary lymph node metastasis
Histopathology - Tập 10 Số 4 - Trang 415-424 - 1986
A breast tumour with proven lymph node metastasis is conclusively characterized
as an adenoid cystic carcinoma using immunocytochemistry and electron
microscopy. The majority of tumour cells showed certain of the characteristic
features of myoepithetial cells while the pseudocystic spaces contained large
amounts of reduplicated basal lamina. A small proportion of tumour cells,
however, showed epit...
Calibration of immunohistochemistry for assessment of HER2 in breast cancer: results of the French Multicentre GEFPICS* Study
Histopathology - Tập 42 Số 4 - Trang 337-347 - 2003
Aims: HER2 protein is over‐expressed in 15–30% of breast carcinomas.
Immunohistochemistry (IHC) is a common and inexpensive method able to
specifically detect HER2 protein. However, lack of standardization of IHC has
been considered responsible for discrepancies in HER2 status assessment
performed by IHC and fluorescence in‐situ hybridization (FISH). This prompted us
to perform a multicentric IHC...
Adenoid cystic carcinoma of the breast: a tumour commonly devoid of oestrogen receptors and related proteins
Histopathology - Tập 35 Số 3 - Trang 241-248 - 1999
AimAdenoid cystic carcinoma (ACC) of the breast is an uncommon
well‐differentiated tumour with good prognosis, and sometimes difficult to
distinguish from in‐situ and invasive cribriform carcinoma (ICC) which are
relatively more common. Recently, we encountered a case of ACC that proved to be
totally oestrogen receptor (ER) negative by immunohistochemistry. We
investigated the possibility that thi...
Slide navigation patterns among pathologists with long experience of digital review
Histopathology - Tập 67 Số 2 - Trang 185-192 - 2015
AimsIn order to develop efficient digital pathology workstations, we studied the
navigation patterns of pathologists diagnosing whole‐slide images. To gain a
better understanding of these patterns, we built a conceptual model based on
observations. We also determined whether or not new navigation patterns have
emerged among pathologists with extensive digital experience.Methods and
resultsFive pat...
Handling of radical prostatectomy specimens: total or partial embedding?
Histopathology - Tập 58 Số 2 - Trang 211-216 - 2011
Vainer B, Toft B G, Olsen K E, Jacobsen G K & Marcussen N
(2011)
Histopathology58, 211–216
Handling of radical prostatectomy specimens: total or
partial embedding?Aims: Proper examination and accurate reporting of radical
prostatectomy specimens (RPS) is essential in determining post‐surgical
treatment and predicting patient outcome. Surveys have demonstrated the absence
of consensus on handling ...
Dysplastic naevi: an update
Histopathology - Tập 56 Số 1 - Trang 112-120 - 2010
Elder D E
(2010) Histopathology56, 112–120
Dysplastic naevi: an updateDysplastic
naevi are clinically atypical and histologically are characterized by
architectural disorder and cytological atypia. Their diagnosis is reproducible
if criteria and thresholds are agreed upon. They are significant only in
relation to melanoma, as simulants of melanoma, as markers of individuals at
increased risk of de...
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