Therapeutic drug monitoring-guided dosing of busulfan differs from weight-based dosing in hematopoietic stem cell transplant patientsHematology/Oncology and Stem Cell Therapy - Tập 10 - Trang 70 - 2017
Salam Al-Kindi, Murtadha Al-Khabori, Bushra Salman, Khalil Al-Farsi, Abdulhakeem Al-Rawas, Melanie Tauro, David Dennison, Mohammed Al-Za'abi, Mohammed Al-Huneini
Busulfan (Bu)-based preparative regimens in hematopoietic stem cell
transplantation are commonly used. Previous studies have shown that Bu at a
fixed dose of 3.2mg/kg/day (FBD) given intravenously decreases variability in
drug pharmacokinetics and this decreases the dependency on therapeutic drug
monitoring (TDM) of Bu. We compared the Bu dose given using TDM with the FBD of
3.2mg/kg/day. Seventy-... hiện toàn bộ
#Busulfan #Pharmacokinetics #Drug monitoring #Hematopoietic stem cell transplantation