GeroScience
2509-2723
Cơ quản chủ quản: SPRINGER , Springer International Publishing AG
Lĩnh vực:
AgingCardiology and Cardiovascular MedicineGeriatrics and GerontologyComplementary and Alternative MedicineVeterinary (miscellaneous)
Các bài báo tiêu biểu
Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation
- 2018
Increase in blood–brain barrier leakage in healthy, older adults Abstract Blood–brain barrier (BBB) breakdown can disrupt nutrient supply and waste removal, which affects neuronal functioning. Currently, dynamic contrast-enhanced (DCE) MRI is the preferred in-vivo method to quantify BBB leakage. Dedicated DCE MRI studies in normal aging individuals are lacking, which could hamper value estimation and interpretation of leakage rate in pathological conditions. Therefore, we applied DCE MRI to investigate the association between BBB disruption and age in a healthy sample. Fifty-seven cognitively and neurologically healthy, middle-aged to older participants (mean age: 66 years, range: 47–91 years) underwent MRI, including DCE MRI with intravenous injection of a gadolinium-based contrast agent. Pharmacokinetic modeling was applied to contrast concentration time-curves to estimate BBB leakage rate in each voxel. Subsequently, leakage rate was calculated in the white and gray matter, and primary (basic sensory and motor functions), secondary (association areas), and tertiary (higher-order cognition) brain regions. A difference in vulnerability to deterioration was expected between these regions, with especially tertiary regions being affected by age. Higher BBB leakage rate was significantly associated with older age in the white and gray matter, and also in tertiary, but not in primary or secondary brain regions. Even in healthy individuals, BBB disruption was stronger in older persons, which suggests BBB disruption is a normal physiologically aging phenomenon. Age-related increase in BBB disruption occurred especially in brain regions most vulnerable to age-related deterioration, which may indicate that BBB disruption is an underlying mechanism of normal age-related decline. Netherlands Trial Register number: NL6358, date of registration: 2017-03-24.
Tập 42 Số 4 - Trang 1183-1193 - 2020
Demonstration of impaired neurovascular coupling responses in TG2576 mouse model of Alzheimer’s disease using functional laser speckle contrast imaging
Tập 39 Số 4 - Trang 465-473 - 2017
Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation–induced impairment of neurovascular coupling responses protecting cognitive function in mice
Tập 42 Số 2 - Trang 409-428 - 2020
Does SARS-CoV-2 infection cause chronic neurological complications?
Tập 42 Số 4 - Trang 1083-1087 - 2020