Increase in blood–brain barrier leakage in healthy, older adults Tập 42 Số 4 - Trang 1183-1193 - 2020
Inge C.M. Verheggen, Joost J.A. de Jong, Martin P.J. van Boxtel, E. H. B. M. Gronenschild, Walter M. Palm, Alida A. Postma, Jacobus F.A. Jansen, Frans R.J. Verhey, Walter H. Backes
AbstractBlood–brain barrier (BBB) breakdown can disrupt nutrient supply and
waste removal, which affects neuronal functioning. Currently, dynamic
contrast-enhanced (DCE) MRI is the preferred in-vivo method to quantify BBB
leakage. Dedicated DCE MRI studies in normal aging individuals are lacking,
which could hamper value estimation and interpretation of leakage rate in
pathological conditions. The... hiện toàn bộ
Age-related impairment of neurovascular coupling responses: a dynamic vessel analysis (DVA)-based approach to measure decreased flicker light stimulus-induced retinal arteriolar dilation in healthy older adults Tập 41 - Trang 341-349 - 2019
Agnes Lipecz, Tamas Csipo, Stefano Tarantini, Rachel A. Hand, Bich-Thy N. Ngo, Shannon Conley, Gabor Nemeth, Alexis Tsorbatzoglou, Donald L. Courtney, Valeriya Yabluchanska, Anna Csiszar, Zoltan I. Ungvari, Andriy Yabluchanskiy
Aging is a major risk factor for vascular cognitive impairment and dementia
(VCID). Recent studies demonstrate that cerebromicrovascular dysfunction plays a
causal role in the development of age-related cognitive impairment, in part via
disruption of neurovascular coupling (NVC) responses. NVC (functional hyperemia)
is responsible for adjusting cerebral blood flow to the increased energetic
demand... hiện toàn bộ
Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation–induced impairment of neurovascular coupling responses protecting cognitive function in mice Tập 42 Số 2 - Trang 409-428 - 2020
Andriy Yabluchanskiy, Stefano Tarantini, Priya Balasubramanian, Tamás Kiss, Tamás Csípő, Gábor Fülöp, Ágnes Lipécz, Chetan Ahire, Jordan DelFavero, Ádám Nyúl‐Tóth, William E. Sonntag, Michal Laniado Schwartzman, Judith Campisi, Anna Csiszár, Zoltán Ungvári
Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice - 2019
Gabriela E. Farias Quipildor, Kai Mao, Zunju Hu, Ardijana Novaj, Min Cui, Maria Gulinello, Craig A. Branch, Sriram Gubbi, Khushbu Patel, Douglas R. Moellering, Stefano Tarantini, Tamás Kiss, Andriy Yabluchanskiy, Zoltán Ungvári, William E. Sonntag, Derek M. Huffman