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Genome-wide analysis of hepatic DNA methylation reveals impact of epigenetic aging on xenobiotic metabolism and transport genes in an aged mouse model
GeroScience -
AbstractHepatic xenobiotic metabolism and transport decline with age, while
intact xenobiotic metabolism is associated with longevity. However, few studies
have examined the genome-wide impact of epigenetic aging on these processes. We
used reduced representation bisulfite sequencing (RRBS) to map DNA methylation
changes in liver DNA from mice ages 4 and 24 months. We identified several
thousand a...
Factors influencing gait performance in older adults in a dual-task paradigm
GeroScience - - Trang 1-13 - 2024
The aim of this study was to determine the effect of cognitive interference
through a dual-task (DT) paradigm on gait parameters by sex or other predictive
variables, such as physical fitness, health status, and cognition. A total of
125 older adults joined in this study (age, 72.42 ± 5.56 years old; 28 men and
97 women). The DT paradigm was evaluated through Comfortable Linear Gait (CLG)
and Comp...
Astaxanthin supplementation modulates cognitive function and synaptic plasticity in young and aged mice
GeroScience - Tập 41 - Trang 77-87 - 2019
The incidence of neurodegenerative disorders and cognitive impairment is
increasing. Rising prevalence of age-related medical conditions is associated
with a dramatic economic burden; therefore, developing strategies to manage
these health concerns is of great public health interest. Nutritionally based
interventions have shown promise in treatment of these age-associated
conditions. Astaxanthin i...
SARS-CoV-2 infection in HIV-infected patients: potential role in the high mutational load of the Omicron variant emerging in South Africa
GeroScience - Tập 44 Số 5 - Trang 2337-2345 - 2022
AbstractA new variant of SARS-CoV-2 named Omicron (B.1.1.529) was isolated from
an HIV-infected patient in Botswana, South Africa, in November 2021. Whole
genome sequencing revealed a multitude of mutations and its relationship to the
mutation-rich Alpha variant that had been isolated from a cancer patient. It is
conceivable that very high prevalence of HIV-infected individuals as susceptible
host...
Man’s best friend in life and death: scientific perspectives and challenges of dog brain banking
GeroScience - Tập 43 Số 4 - Trang 1653-1668 - 2021
AbstractBiobanking refers to the systematic collection, storage, and
distribution of pre- or post-mortem biological samples derived from volunteer
donors. The demand for high-quality human specimens is clearly demonstrated by
the number of newly emerging biobanking facilities and large international
collaborative networks. Several animal species are relevant today in medical
research; therefore, s...
Einstein-Nathan Shock Center: translating the hallmarks of aging to extend human health span
GeroScience - Tập 43 - Trang 2167-2182 - 2021
The overarching mission of the Einstein-Nathan Shock Center (E-NSC) is to make
scientific discoveries in geroscience, leveraging on the expertise in our center
in 6 out of the 7 pillars of aging, and to translate their effects towards drug
discovery. The relevance of this basic biology of aging discoveries to humans
will be confirmed through the unique gero-human resource at E-NSC. This is
achieve...
Relationship of psychotropic medication use with physical function among postmenopausal women
GeroScience - - 2024
To examine cross-sectional and longitudinal relationships of psychotropic
medications with physical function after menopause. Analyses involved 4557
Women’s Health Initiative Long Life Study (WHI-LLS) participants (mean age at
WHI enrollment (1993–1998): 62.8 years). Antidepressant, anxiolytic, and
sedative/hypnotic medications were evaluated at WHI enrollment and 3-year
follow-up visits. Performa...
The frailty index outperforms DNA methylation age and its derivatives as an indicator of biological age
GeroScience - Tập 39 - Trang 83-92 - 2017
The measurement of biological age as opposed to chronological age is important
to allow the study of factors that are responsible for the heterogeneity in the
decline in health and function ability among individuals during aging. Various
measures of biological aging have been proposed. Frailty indices based on health
deficits in diverse body systems have been well studied, and we have documented
t...
A robust machine learning framework to identify signatures for frailty: a nested case-control study in four aging European cohorts
GeroScience - Tập 43 - Trang 1317-1329 - 2021
Phenotype-specific omic expression patterns in people with frailty could provide
invaluable insight into the underlying multi-systemic pathological processes and
targets for intervention. Classical approaches to frailty have not considered
the potential for different frailty phenotypes. We characterized associations
between frailty (with/without disability) and sets of omic factors (genomic,
prote...
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