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Geroprotective interventions in the 3xTg mouse model of Alzheimer’s disease
GeroScience - Tập 45 - Trang 1343-1381 - 2023
Michelle M. Sonsalla, Dudley W. Lamming
Alzheimer’s disease (AD) is an age-associated neurodegenerative disease. As the population ages, the increasing prevalence of AD threatens massive healthcare costs in the coming decades. Unfortunately, traditional drug development efforts for AD have proven largely unsuccessful. A geroscience approach to AD suggests that since aging is the main driver of AD, targeting aging itself may be an effect...... hiện toàn bộ
Deprescribing in cardiometabolic conditions in older patients: a systematic review
GeroScience - Tập 45 - Trang 3491-3512 - 2023
Elizabeth Hickman, Mansha Seawoodharry, Clare Gillies, Kamlesh Khunti, Samuel Seidu
We conduct a systematic review to investigate current deprescribing practices and evaluate outcomes and adverse events with deprescribing of preventive medications in older patients with either an end-of-life designation or residing in long-term care facilities with cardiometabolic conditions. Studies were identified using a literature search of MEDLINE, EMBASE, Web of Science, clinicaltrials.gov....... hiện toàn bộ
Aging, stress, and senescence in plants: what can biological diversity teach us?
GeroScience - Tập 43 - Trang 167-180 - 2021
Marina Pérez-Llorca, Sergi Munné-Bosch
Aging, stress, and senescence in plants are interconnected processes that determine longevity. We focus here on compiling and discussing our current knowledge on the mechanisms of development that long-lived perennial plants have evolved to prevent and delay senescence. Clonal and nonclonal perennial herbs of various life forms and longevities will be particularly considered to illustrate what bio...... hiện toàn bộ
Microglial MHC-I induction with aging and Alzheimer’s is conserved in mouse models and humans
GeroScience - Tập 45 - Trang 3019-3043 - 2023
Collyn M. Kellogg, Kevin Pham, Adeline H. Machalinski, Hunter L. Porter, Harris E. Blankenship, Kyla B. Tooley, Michael B. Stout, Heather C. Rice, Amanda L. Sharpe, Michael J. Beckstead, Ana J. Chucair-Elliott, Sarah R. Ocañas, Willard M. Freeman
Major histocompatibility complex I (MHC-I) CNS cellular localization and function is still being determined after previously being thought to be absent from the brain. MHC-I expression has been reported to increase with brain aging in mouse, rat, and human whole tissue analyses, but the cellular localization was undetermined. Neuronal MHC-I is proposed to regulate developmental synapse elimination...... hiện toàn bộ
Angiotensin receptor blocker use is associated with upregulation of the memory-protective angiotensin type 4 receptor (AT4R) in the postmortem brains of individuals without cognitive impairment
GeroScience - - 2023
Çağlar Coşarderelioğlu, Lolita S. Nidadavolu, Claudene J. George, Ruth Marx-Rattner, Laura Powell, Qian‐Li Xue, Jing Tian, Esther S. Oh, Luigi Ferrucci, Pervin Dinçer, David A. Bennett, Jeremy D. Walston, Peter M. Abadir
Identification of biomarkers for physical frailty and sarcopenia through a new multi-marker approach: results from the BIOSPHERE study
GeroScience - Tập 43 - Trang 727-740 - 2020
Riccardo Calvani, Anna Picca, Federico Marini, Alessandra Biancolillo, Jacopo Gervasoni, Silvia Persichilli, Aniello Primiano, Hélio J. Coelho-Junior, Matteo Cesari, Maurizio Bossola, Andrea Urbani, Graziano Onder, Francesco Landi, Roberto Bernabei, Emanuele Marzetti
Physical frailty and sarcopenia (PF&S) is a prototypical geriatric condition characterized by reduced physical function and low muscle mass. The aim of the present study was to provide an initial selection of biomarkers for PF&S using a novel multivariate analytic strategy. Two-hundred community-dwellers, 100 with PF&S and 100 non-physically frail, non-sarcopenic (nonPF&S) controls aged 70 and old...... hiện toàn bộ
Growth hormone increases DNA damage in ovarian follicles and macrophage infiltration in the ovaries
GeroScience - - 2022
Tatiana D. Saccon, Monique Tomazele Rovani, Driele Neske Garcia, J. Pradieé, Rafael Gianella Mondadori, Luis A. Cruz, Carlos Castilho Barros, Yimin Fang, Samuel McFadden, Jeffrey B. Mason, Andrzej Bartke, Michał M. Masternak, Augusto Schneider
High-velocity resistance training mitigates physiological and functional impairments in middle-aged and older adults with and without mobility-limitation
GeroScience - - 2022
Gustavo Z. Schaun, Marcas M. Bamman, Luana Siqueira Andrade, Gabriela Barreto David, Vitor L. Krüger, Eduardo Frio Marins, Gabriela Neves Nunes, Mariana Silva Häfele, Graciele Ferreira Mendes, Maria Laura Brizio Gomes, Paula Campelo, Ronei Silveira Pinto, Cristine Lima Alberton
Imaging retinal microvascular manifestations of carotid artery disease in older adults: from diagnosis of ocular complications to understanding microvascular contributions to cognitive impairment
GeroScience - Tập 43 - Trang 1703-1723 - 2021
Lilla István, Cecilia Czakó, Ágnes Élő, Zsuzsanna Mihály, Péter Sótonyi, Andrea Varga, Zoltán Ungvári, Anna Csiszár, Andriy Yabluchanskiy, Shannon Conley, Tamás Csipő, Ágnes Lipecz, Illés Kovács, Zoltán Zsolt Nagy
Carotid artery stenosis (CAS) is a consequence of systemic atherosclerotic disease affecting the aging populations of the Western world. CAS is frequently associated with cognitive impairment. However, the mechanisms contributing to the development of vascular cognitive impairment (VCI) associated with CAS are multifaceted and not fully understood. In addition to embolization and decreased blood f...... hiện toàn bộ
Drug synergy as a strategy for compression of morbidity in a Caenorhabditis elegans model of Alzheimer’s disease
GeroScience - Tập 42 - Trang 849-856 - 2020
Emelyne Teo, Sheng Fong, Nicholas Tolwinski, Jan Gruber
Alzheimer’s disease (AD) is the most common cause of dementia worldwide. AD is a multifactorial disease with simultaneous occurrence of several connected pathological processes including mitochondrial dysfunction and impaired proteostasis. Most of these are also implicated in organismal aging per se. The presence of separable pathological conditions poses the opportunity to try combination treatme...... hiện toàn bộ
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