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Factors influencing gait performance in older adults in a dual-task paradigm
GeroScience - - Trang 1-13 - 2024
The aim of this study was to determine the effect of cognitive interference through a dual-task (DT) paradigm on gait parameters by sex or other predictive variables, such as physical fitness, health status, and cognition. A total of 125 older adults joined in this study (age, 72.42 ± 5.56 years old; 28 men and 97 women). The DT paradigm was evaluated through Comfortable Linear Gait (CLG) and Comp......
Einstein-Nathan Shock Center: translating the hallmarks of aging to extend human health span
GeroScience - Tập 43 - Trang 2167-2182 - 2021
The overarching mission of the Einstein-Nathan Shock Center (E-NSC) is to make scientific discoveries in geroscience, leveraging on the expertise in our center in 6 out of the 7 pillars of aging, and to translate their effects towards drug discovery. The relevance of this basic biology of aging discoveries to humans will be confirmed through the unique gero-human resource at E-NSC. This is achieve......
The frailty index outperforms DNA methylation age and its derivatives as an indicator of biological age
GeroScience - Tập 39 - Trang 83-92 - 2017
The measurement of biological age as opposed to chronological age is important to allow the study of factors that are responsible for the heterogeneity in the decline in health and function ability among individuals during aging. Various measures of biological aging have been proposed. Frailty indices based on health deficits in diverse body systems have been well studied, and we have documented t......
Early-life educational attainment, APOE ε4 alleles, and incident dementia risk in late life
GeroScience - Tập 44 - Trang 1479-1488 - 2022
We examined the interactions between educational attainment and genetic susceptibility on dementia risk among adults over 60 years old. A total of 174,161 participants were free of dementia at baseline. The APOE ε4–related genetic risk was evaluated by the number of APOE ε4 alleles. The overall genetic susceptibility of dementia was evaluated by polygenetic risk score (PRS). Cox proportional hazar......
Associations between sociodemographic factors, health spending, disease burden, and life expectancy of older adults (70 + years old) in 22 countries in the Western Pacific Region, 1995–2019: estimates from the Global Burden of Disease (GBD) Study 2019
GeroScience - Tập 44 - Trang 925-951 - 2022
The needs of the aging populations are putting increasing burden on healthcare particularly in the Western Pacific Region (WPR), which is the home of aging economies such as Hong Kong and Japan alongside rapid increases in older people in low- and middle-income countries (LMICs). However, little is known about the associations between sociodemographic factors, disease burden, and life expectancy i......
Hypothalamic microstructure and function are related to body mass, but not mental or cognitive abilities across the adult lifespan
GeroScience - Tập 45 - Trang 277-291 - 2022
Physical, mental, and cognitive resources are essential for healthy aging. Aging impacts on the structural integrity of various brain regions, including the hippocampus. Even though recent rodent studies hint towards a critical role of the hypothalamus, there is limited evidence on functional consequences of age-related changes of this region in humans. Given its central role in metabolic regulati......
Molecular cross-talk between long COVID-19 and Alzheimer’s diseaseAbstract The long COVID (coronavirus disease), a multisystemic condition following severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, is one of the widespread problems. Some of its symptoms affect the nervous system and resemble symptoms of Alzheimer’s disease (AD)—a neurodegenerative condition caused by the accumulation of amyloid beta and hype... ...
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Physiological phenotypes have optimal values relevant to healthy aging: sweet spots deduced from the Canadian Longitudinal Study on Aging
GeroScience - - Trang 1-17 - 2023
Previous observations on a group of exceptionally healthy “Super-Seniors” showed a lower variance of multiple physiological measures relevant for health than did a less healthy group of the same age. The finding was interpreted as the healthier individuals having physiological measurement values closer to an optimal level, or “sweet spot.” Here, we tested the generalizability of the sweet-spot hyp......
Investigating impacts of the mycothiazole chemotype as a chemical probe for the study of mitochondrial function and aging
GeroScience - - 2024
Small molecule inhibitors of the mitochondrial electron transport chain (ETC) hold significant promise to provide valuable insights to the field of mitochondrial research and aging biology. In this study, we investigated two molecules: mycothiazole (MTZ) - from the marine sponge C. mycofijiensis and its more stable semisynthetic analog 8-O-acetylmycothiazole (8-OAc) as potent and selective chemica......
Translatability of mouse muscle-aging for humans: the role of sexAbstract Muscle-aging drives sarcopenia and is a major public health issue. Mice are frequently used as a model for human muscle-aging, however, research investigating their translational value is limited. In addition, mechanisms underlying muscle-aging may have sex-specific features in humans, but it is not yet assessed whether these are recapitulated in mice. Here... ...
GeroScience - Tập 46 Số 3 - Trang 3341-3360
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