GeroScience

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Genome-wide analysis of hepatic DNA methylation reveals impact of epigenetic aging on xenobiotic metabolism and transport genes in an aged mouse model
GeroScience -
Sara Abudahab, Mohamad M. Kronfol, Mikhail G. Dozmorov, Thomas J. Campbell, Fay M. Jahr, Jasmine Nguyen, Ola AlAzzeh, Dalia Al Saeedy, Andrea Victor, S. G. Lee, Shravani Malay, Dana M. Lapato, Matthew S. Halquist, MaryPeace McRae, Laxmikant S. Deshpande, Patricia W. Slattum, Elvin Price, Joseph L. McClay
AbstractHepatic xenobiotic metabolism and transport decline with age, while intact xenobiotic metabolism is associated with longevity. However, few studies have examined the genome-wide impact of epigenetic aging on these processes. We used reduced representation bisulfite sequencing (RRBS) to map DNA methylation changes in liver DNA from mice ages 4 and 24 months. We identified several thousand a... hiện toàn bộ
Factors influencing gait performance in older adults in a dual-task paradigm
GeroScience - - Trang 1-13 - 2024
Karina Elizabeth Andrade Lara, José Carlos Cabrera Linares, Juan Antonio Párraga Montilla, Pedro Ángel Latorre Román
The aim of this study was to determine the effect of cognitive interference through a dual-task (DT) paradigm on gait parameters by sex or other predictive variables, such as physical fitness, health status, and cognition. A total of 125 older adults joined in this study (age, 72.42 ± 5.56 years old; 28 men and 97 women). The DT paradigm was evaluated through Comfortable Linear Gait (CLG) and Comp... hiện toàn bộ
Combining exercise with cognitive training and vitamin D3 to improve functional brain connectivity (FBC) in older adults with mild cognitive impairment (MCI). Results from the SYNERGIC trial
GeroScience -
Nick W. Bray, Frederico Pieruccini‐Faria, Suzanne T. Witt, Robert Bartha, Timothy J. Doherty, Lindsay S. Nagamatsu, Quincy J. Almeida, Teresa Liu-Ambrose, Laura Middleton, Louis Bherer, Manuel Montero‐Odasso
Astaxanthin supplementation modulates cognitive function and synaptic plasticity in young and aged mice
GeroScience - Tập 41 - Trang 77-87 - 2019
Bethany Grimmig, Charles Hudson, Lauren Moss, Melinda Peters, Meena Subbarayan, Edwin J. Weeber, Paula C. Bickford
The incidence of neurodegenerative disorders and cognitive impairment is increasing. Rising prevalence of age-related medical conditions is associated with a dramatic economic burden; therefore, developing strategies to manage these health concerns is of great public health interest. Nutritionally based interventions have shown promise in treatment of these age-associated conditions. Astaxanthin i... hiện toàn bộ
SARS-CoV-2 infection in HIV-infected patients: potential role in the high mutational load of the Omicron variant emerging in South Africa
GeroScience - Tập 44 Số 5 - Trang 2337-2345 - 2022
Katalin Réka Tarcsai, Oliga Corolciuc, Attila Tordai, J Ongrádi
AbstractA new variant of SARS-CoV-2 named Omicron (B.1.1.529) was isolated from an HIV-infected patient in Botswana, South Africa, in November 2021. Whole genome sequencing revealed a multitude of mutations and its relationship to the mutation-rich Alpha variant that had been isolated from a cancer patient. It is conceivable that very high prevalence of HIV-infected individuals as susceptible host... hiện toàn bộ
Man’s best friend in life and death: scientific perspectives and challenges of dog brain banking
GeroScience - Tập 43 Số 4 - Trang 1653-1668 - 2021
Sára Sándor, Kálmán Czeibert, Attila Salamon, Enikő Kubinyi
AbstractBiobanking refers to the systematic collection, storage, and distribution of pre- or post-mortem biological samples derived from volunteer donors. The demand for high-quality human specimens is clearly demonstrated by the number of newly emerging biobanking facilities and large international collaborative networks. Several animal species are relevant today in medical research; therefore, s... hiện toàn bộ
Changes in cAMP signaling are associated with age-related downregulation of spontaneously beating atrial tissue energetic indices
GeroScience - Tập 45 - Trang 209-219 - 2022
Noa Kirschner Peretz, Sofia Segal, Rotem Shapira, Ori Shemla, Yevgeniya Lukyanenko, Inbar Brosh, Edward G. Lakatta, Kenta Tsutsui, Yael Yaniv
The prevalence of atria-related diseases increases exponentially with age and is associated with ATP supply-to-demand imbalances. Because evidence suggests that cAMP regulates ATP supply-to-demand, we explored aged-associated alterations in atrial ATP supply-to-demand balance and its correlation with cAMP levels. Right atrial tissues driven by spontaneous sinoatrial node impulses were isolated fro... hiện toàn bộ
Einstein-Nathan Shock Center: translating the hallmarks of aging to extend human health span
GeroScience - Tập 43 - Trang 2167-2182 - 2021
Ana Maria Cuervo, Derek M. Huffman, Jan Vijg, Sofiya Milman, Rajat Singh, Nir Barzilai
The overarching mission of the Einstein-Nathan Shock Center (E-NSC) is to make scientific discoveries in geroscience, leveraging on the expertise in our center in 6 out of the 7 pillars of aging, and to translate their effects towards drug discovery. The relevance of this basic biology of aging discoveries to humans will be confirmed through the unique gero-human resource at E-NSC. This is achieve... hiện toàn bộ
Relationship of psychotropic medication use with physical function among postmenopausal women
GeroScience - - 2024
Hind A. Beydoun, May A. Beydoun, Edward Kwon, Brook T. Alemu, Alan B. Zonderman, Robert Brunner
To examine cross-sectional and longitudinal relationships of psychotropic medications with physical function after menopause. Analyses involved 4557 Women’s Health Initiative Long Life Study (WHI-LLS) participants (mean age at WHI enrollment (1993–1998): 62.8 years). Antidepressant, anxiolytic, and sedative/hypnotic medications were evaluated at WHI enrollment and 3-year follow-up visits. Performa... hiện toàn bộ
The frailty index outperforms DNA methylation age and its derivatives as an indicator of biological age
GeroScience - Tập 39 - Trang 83-92 - 2017
Sangkyu Kim, Leann Myers, Jennifer Wyckoff, Katie E. Cherry, S. Michal Jazwinski
The measurement of biological age as opposed to chronological age is important to allow the study of factors that are responsible for the heterogeneity in the decline in health and function ability among individuals during aging. Various measures of biological aging have been proposed. Frailty indices based on health deficits in diverse body systems have been well studied, and we have documented t... hiện toàn bộ
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