Genetics

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The genetics of catalase in Drosophila melanogaster: isolation and characterization of acatalasemic mutants.
Genetics - Tập 122 Số 3 - Trang 643-652 - 1989
William J. Mackay, Glenn C. Bewley
Abstract Activated oxygen species have been demonstrated to be the important agents in oxygen toxicity by disrupting the structural and functional integrity of cells through lipid peroxidation events, DNA damage and protein inactivation. The biological consequences of free radical damage have long been hypothesized to be a causal agent in many aging-related diseases. Catalase (H2O2:H2O2 oxidoreduc... hiện toàn bộ
An Allele of RFA1 Suppresses RAD52-Dependent Double-Strand Break Repair in Saccharomyces cerevisiae
Genetics - Tập 151 Số 2 - Trang 447-458 - 1999
Julianne Smith, Rodney Rothstein
Abstract An allele of RFA1, the largest subunit of the single-stranded DNA-binding complex RP-A, was identified as a suppressor of decreased direct-repeat recombination in rad1 rad52 double mutants. In this study, we used two LEU2 direct-repeat assays to investigate the mechanism by which the rfa1-D228Y allele increases recombination. We found that both intrachromatid and sister chromatid recombin... hiện toàn bộ
Requirement for Three Novel Protein Complexes in the Absence of the Sgs1 DNA Helicase in Saccharomyces cerevisiae
Genetics - Tập 157 Số 1 - Trang 103-118 - 2001
Janet R. Mullen, Vivek Kaliraman, Samer Ibrahim, Steven J. Brill
Abstract The Saccharomyces cerevisiae Sgs1 protein is a member of the RecQ family of DNA helicases and is required for genome stability, but not cell viability. To identify proteins that function in the absence of Sgs1, a synthetic-lethal screen was performed. We obtained mutations in six complementation groups that we refer to as SLX genes. Most of the SLX genes encode uncharacterized open readin... hiện toàn bộ
Genomic Prediction in Animals and Plants: Simulation of Data, Validation, Reporting, and Benchmarking
Genetics - Tập 193 Số 2 - Trang 347-365 - 2013
Hans D. Daetwyler, M.P.L. Calus, Ricardo Pong‐Wong, Gustavo de los Campos, John M. Hickey
AbstractThe genomic prediction of phenotypes and breeding values in animals and plants has developed rapidly into its own research field. Results of genomic prediction studies are often difficult to compare because data simulation varies, real or simulated data are not fully described, and not all relevant results are reported. In addition, some new methods have been compared only in limited genet... hiện toàn bộ
Meuwissen et al. on Genomic Selection
Genetics - Tập 203 Số 1 - Trang 5-7 - 2016
Dirk‐Jan de Koning
The Extent of Linkage Disequilibrium in Rice (Oryza sativa L.)
Genetics - Tập 177 Số 4 - Trang 2223-2232 - 2007
Kristie A. Mather, Ana L. Caicedo, Nicholas R. Polato, Kenneth M. Olsen, Susan R. McCouch, Michael D. Purugganan
Abstract Despite its status as one of the world's major crops, linkage disequilibrium (LD) patterns have not been systematically characterized across the genome of Asian rice (Oryza sativa). Such information is critical to fully exploit the genome sequence for mapping complex traits using association techniques. Here we characterize LD in five 500-kb regions of the rice genome in three major culti... hiện toàn bộ
Needles: Toward Large-Scale Genomic Prediction with Marker-by-Environment Interaction
Genetics - Tập 203 Số 1 - Trang 543-555 - 2016
Arne De Coninck, Bernard De Baets, Drosos Kourounis, Fabio Verbosio, Olaf Schenk, Steven Maenhout, Jan Fostier
Abstract Genomic prediction relies on genotypic marker information to predict the agronomic performance of future hybrid breeds based on trial records. Because the effect of markers may vary substantially under the influence of different environmental conditions, marker-by-environment interaction effects have to be taken into account. However, this may lead to a dramatic increase in the computatio... hiện toàn bộ
Involvement ofEscherichia coliDNA Polymerase IV in Tolerance of Cytotoxic Alkylating DNA Lesionsin Vivo
Genetics - Tập 176 Số 3 - Trang 1431-1440 - 2007
Ivana Bjedov, Chitralekha Nag Dasgupta, Dea Slade, Sophie Le Blastier, Marjorie Selva, Ivan Matić
AbstractEscherichia coli PolIV, a DNA polymerase capable of catalyzing synthesis past replication-blocking DNA lesions, belongs to the most ubiquitous branch of Y-family DNA polymerases. The goal of this study is to identify spontaneous DNA damage that is bypassed specifically and accurately by PolIV in vivo. We increased the amount of spontaneous DNA lesions using mutants deficient for different ... hiện toàn bộ
Mutants of Escherichia coli with increased fidelity of DNA replication.
Genetics - Tập 134 Số 4 - Trang 1023-1030 - 1993
Iwona J. Fijałkowska, R L Dunn, Roel M. Schaaper
Abstract To improve our understanding of the role of DNA replication fidelity in mutagenesis, we undertook a search for Escherichia coli antimutator strains with increased fidelity of DNA replication. The region between 4 and 5 min of the E. coli chromosome was mutagenized using localized mutagenesis mediated by bacteriophage P1. This region contains the dnaE and dnaQ genes, which encode, respecti... hiện toàn bộ
Bipartite Inhibition of Drosophila Epidermal Growth Factor Receptor by the Extracellular and Transmembrane Domains of Kekkon1
Genetics - Tập 167 Số 1 - Trang 187-202 - 2004
Diego Alvarado, Amy H Rice, Joseph B. Duffy
AbstractIn Drosophila, signaling by the epidermal growth factor receptor (EGFR) is required for a diverse array of developmental decisions. Essential to these decisions is the precise regulation of the receptor's activity by both stimulatory and inhibitory molecules. To better understand the regulation of EGFR activity we investigated inhibition of EGFR by the transmembrane protein Kekkon1 (Kek1).... hiện toàn bộ
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