The genetics of catalase in Drosophila melanogaster: isolation and characterization of acatalasemic mutants.Genetics - Tập 122 Số 3 - Trang 643-652 - 1989
William J. Mackay, Glenn C. Bewley
Abstract
Activated oxygen species have been demonstrated to be the important agents in oxygen toxicity by disrupting the structural and functional integrity of cells through lipid peroxidation events, DNA damage and protein inactivation. The biological consequences of free radical damage have long been hypothesized to be a causal agent in many aging-...... hiện toàn bộ
The Extent of Linkage Disequilibrium in Rice (Oryza sativa L.)Genetics - Tập 177 Số 4 - Trang 2223-2232 - 2007
Kristie A. Mather, Ana L. Caicedo, Nicholas R. Polato, Kenneth M. Olsen, Susan R. McCouch, Michael D. Purugganan
Abstract
Despite its status as one of the world's major crops, linkage disequilibrium (LD) patterns have not been systematically characterized across the genome of Asian rice (Oryza sativa). Such information is critical to fully exploit the genome sequence for mapping complex traits using association techniques. Here we characterize LD in five 500-kb...... hiện toàn bộ
Involvement ofEscherichia coliDNA Polymerase IV in Tolerance of Cytotoxic Alkylating DNA Lesionsin VivoGenetics - Tập 176 Số 3 - Trang 1431-1440 - 2007
Ivana Bjedov, Chitralekha Nag Dasgupta, Dea Slade, Sophie Le Blastier, Marjorie Selva, Ivan Matić
AbstractEscherichia coli PolIV, a DNA polymerase capable of catalyzing synthesis past replication-blocking DNA lesions, belongs to the most ubiquitous branch of Y-family DNA polymerases. The goal of this study is to identify spontaneous DNA damage that is bypassed specifically and accurately by PolIV in vivo. We increased the amount of spontaneous DNA lesions using...... hiện toàn bộ
Mutants of Escherichia coli with increased fidelity of DNA replication.Genetics - Tập 134 Số 4 - Trang 1023-1030 - 1993
Iwona J. Fijałkowska, R L Dunn, Roel M. Schaaper
Abstract
To improve our understanding of the role of DNA replication fidelity in mutagenesis, we undertook a search for Escherichia coli antimutator strains with increased fidelity of DNA replication. The region between 4 and 5 min of the E. coli chromosome was mutagenized using localized mutagenesis mediated by bacteriophage P1. This region contains...... hiện toàn bộ
Multiple Quantitative Trait Locus Analysis of Bovine Chromosome 6 in the Israeli Holstein Population by a Daughter DesignGenetics - Tập 159 Số 2 - Trang 727-735 - 2001
Micha Ron, David Kliger, E. Feldmesser, Eyal Seroussi, E. Ezra, J.I. Weller
Abstract
Nine Israeli Holstein sire families with 2978 daughters were analyzed for quantitative trait loci effects on chromosome 6 for five milk production traits by a daughter design. All animals were genotyped for 2 markers. The three families with significant effects were genotyped for up to 10 additional markers spanning positions 0–122 cM of BTA...... hiện toàn bộ
Association Mapping of Kernel Size and Milling Quality in Wheat (Triticum aestivum L.) CultivarsGenetics - Tập 172 Số 2 - Trang 1165-1177 - 2006
F. Breseghello, Mark E. Sorrells
Abstract
Association mapping is a method for detection of gene effects based on linkage disequilibrium (LD) that complements QTL analysis in the development of tools for molecular plant breeding. In this study, association mapping was performed on a selected sample of 95 cultivars of soft winter wheat. Population structure was estimated on the basis ...... hiện toàn bộ
Association of Candidate Genes With Flowering Time and Water-Soluble Carbohydrate Content in Lolium perenne (L.)Genetics - Tập 177 Số 1 - Trang 535-547 - 2007
Leif Skøt, Jan L Humphreys, Mervyn O. Humphreys, Daniel Thorogood, Joe Gallagher, Ruth Sanderson, Ian Armstead, Ian Thomas
Abstract
We describe a candidate gene approach for associating SNPs with variation in flowering time and water-soluble carbohydrate (WSC) content and other quality traits in the temperate forage grass species Lolium perenne. Three analysis methods were used, which took the significant population structure into account. First, a linear mixed model was...... hiện toàn bộ