Genetics

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The genetics of catalase in Drosophila melanogaster: isolation and characterization of acatalasemic mutants.
Genetics - Tập 122 Số 3 - Trang 643-652 - 1989
William J. Mackay, Glenn C. Bewley
Abstract Activated oxygen species have been demonstrated to be the important agents in oxygen toxicity by disrupting the structural and functional integrity of cells through lipid peroxidation events, DNA damage and protein inactivation. The biological consequences of free radical damage have long been hypothesized to be a causal agent in many aging-...... hiện toàn bộ
Requirement for Three Novel Protein Complexes in the Absence of the Sgs1 DNA Helicase in Saccharomyces cerevisiae
Genetics - Tập 157 Số 1 - Trang 103-118 - 2001
Janet R. Mullen, Vivek Kaliraman, Samer Ibrahim, Steven J. Brill
Abstract The Saccharomyces cerevisiae Sgs1 protein is a member of the RecQ family of DNA helicases and is required for genome stability, but not cell viability. To identify proteins that function in the absence of Sgs1, a synthetic-lethal screen was performed. We obtained mutations in six complementation groups that we refer to as SLX genes. Most of ...... hiện toàn bộ
The Extent of Linkage Disequilibrium in Rice (Oryza sativa L.)
Genetics - Tập 177 Số 4 - Trang 2223-2232 - 2007
Kristie A. Mather, Ana L. Caicedo, Nicholas R. Polato, Kenneth M. Olsen, Susan R. McCouch, Michael D. Purugganan
Abstract Despite its status as one of the world's major crops, linkage disequilibrium (LD) patterns have not been systematically characterized across the genome of Asian rice (Oryza sativa). Such information is critical to fully exploit the genome sequence for mapping complex traits using association techniques. Here we characterize LD in five 500-kb...... hiện toàn bộ
Involvement ofEscherichia coliDNA Polymerase IV in Tolerance of Cytotoxic Alkylating DNA Lesionsin Vivo
Genetics - Tập 176 Số 3 - Trang 1431-1440 - 2007
Ivana Bjedov, Chitralekha Nag Dasgupta, Dea Slade, Sophie Le Blastier, Marjorie Selva, Ivan Matić
AbstractEscherichia coli PolIV, a DNA polymerase capable of catalyzing synthesis past replication-blocking DNA lesions, belongs to the most ubiquitous branch of Y-family DNA polymerases. The goal of this study is to identify spontaneous DNA damage that is bypassed specifically and accurately by PolIV in vivo. We increased the amount of spontaneous DNA lesions using...... hiện toàn bộ
Mutants of Escherichia coli with increased fidelity of DNA replication.
Genetics - Tập 134 Số 4 - Trang 1023-1030 - 1993
Iwona J. Fijałkowska, R L Dunn, Roel M. Schaaper
Abstract To improve our understanding of the role of DNA replication fidelity in mutagenesis, we undertook a search for Escherichia coli antimutator strains with increased fidelity of DNA replication. The region between 4 and 5 min of the E. coli chromosome was mutagenized using localized mutagenesis mediated by bacteriophage P1. This region contains...... hiện toàn bộ
Bipartite Inhibition of Drosophila Epidermal Growth Factor Receptor by the Extracellular and Transmembrane Domains of Kekkon1
Genetics - Tập 167 Số 1 - Trang 187-202 - 2004
Diego Alvarado, Amy H Rice, Joseph B. Duffy
AbstractIn Drosophila, signaling by the epidermal growth factor receptor (EGFR) is required for a diverse array of developmental decisions. Essential to these decisions is the precise regulation of the receptor's activity by both stimulatory and inhibitory molecules. To better understand the regulation of EGFR activity we investigated inhibition of EGFR by the tran...... hiện toàn bộ
Genetic Mechanisms Underlying Apimaysin and Maysin Synthesis and Corn Earworm Antibiosis in Maize (Zea mays L.)
Genetics - Tập 149 Số 4 - Trang 1997-2006 - 1998
E. A. Lee, Patrick F. Byrne, Michael D. McMullen, M. E. Snook, B. R. Wiseman, N. W. Widstrom, E. H. Coe
AbstractC-glycosyl flavones in maize silks confer resistance (i.e., antibiosis) to corn earworm (Helicoverpa zea [Boddie]) larvae and are distinguished by their B-ring substitutions, with maysin and apimaysin being the di- and monohydroxy B-ring forms, respectively. Herein, we examine the genetic mechanisms underlying the synthesis of maysin and apimaysin and the c...... hiện toàn bộ
Spontaneous mutation in the Escherichia coli lacI gene.
Genetics - Tập 129 Số 2 - Trang 317-326 - 1991
Roel M. Schaaper, R L Dunn
Abstract To gain more detailed insight into the nature and mechanisms of spontaneous mutations, we undertook a DNA sequence analysis of a large collection of spontaneous mutations in the N-terminal region of the Escherichia coli lacI gene. This region of circa 210 base pairs is the target for dominant lacI mutations (i-d) and is suitable for studies ...... hiện toàn bộ
Multiple Quantitative Trait Locus Analysis of Bovine Chromosome 6 in the Israeli Holstein Population by a Daughter Design
Genetics - Tập 159 Số 2 - Trang 727-735 - 2001
Micha Ron, David Kliger, E. Feldmesser, Eyal Seroussi, E. Ezra, J.I. Weller
Abstract Nine Israeli Holstein sire families with 2978 daughters were analyzed for quantitative trait loci effects on chromosome 6 for five milk production traits by a daughter design. All animals were genotyped for 2 markers. The three families with significant effects were genotyped for up to 10 additional markers spanning positions 0–122 cM of BTA...... hiện toàn bộ
A New Enhancer of Position-Effect Variegation in Drosophila melanogaster Encodes a Putative RNA Helicase That Binds Chromosomes and Is Regulated by the Cell Cycle
Genetics - Tập 146 Số 3 - Trang 951-963 - 1997
Daniel F. Eberl, Lori J Lorenz, Michael Melnick, Vanita D. Sood, Paul Lasko, Norbert Perrimon
In Drosophila melanogaster, position-effect variegation of the white gene has been a useful phenomenon by which to study chromosome structure and the genes that modify it. We have identified a new enhancer of variegation locus, Dmrnahel (hel). Deletion or mutation of hel enhances white variegation, and this can be reversed by a transformed copy of her  +. In the presence of two endogenous ...... hiện toàn bộ
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