Genesis
SCIE-ISI SCOPUS (2000-2023)
1526-954X
1526-968X
Mỹ
Cơ quản chủ quản: WILEY , Wiley-Liss Inc.
Lĩnh vực:
EndocrinologyGeneticsMedicine (miscellaneous)Cell Biology
Các bài báo tiêu biểu
A global double‐fluorescent Cre reporter mouseAbstract The Cre/loxP system has been used extensively for conditional mutagenesis in mice. Reporters of Cre activity are important for defining the spatial and temporal extent of Cre‐mediated recombination. Here we describe mT/mG , a double‐fluorescent Cre reporter mouse that expresses membrane‐targeted tandem dimer Tomato (mT) prior to Cr... ... hiện toàn bộ
Tập 45 Số 9 - Trang 593-605 - 2007
Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancerAbstract Summary: We have used a Prx1 limb enhancer to drive expression of Cre Recombinase in transgenic mice. This regulatory element leads to Cre expression throughout the early limb bud mesenchyme and in a subset of craniofacial mesenchyme. Crossing a murine line carrying this transgene to a reporter mouse harboring a floxed Cre‐reporte... ... hiện toàn bộ
Tập 33 Số 2 - Trang 77-80 - 2002
hGFAP‐cre transgenic mice for manipulation of glial and neuronal function in vivoAbstract With the goal of performing astrocyte‐specific modification of genes in the mouse, we have generated a transgenic line expressing Cre recombinase under the control of the human glial fibrillary acidic protein (hGFAP) promoter. Activity was monitored by crossing the hGFAP‐cre transgenics with either of two reporter lines carrying a lacZ... hiện toàn bộ
Tập 31 Số 2 - Trang 85-94 - 2001
Genetic targeting of principal neurons in neocortex and hippocampus of NEX-Cre mice
Tập 44 Số 12 - Trang 611-621 - 2006
Consequences of knocking out BMP signaling in the mouseAbstract Summary: During the past two decades, a significant amount of data has been accumulated revealing the intriguing functions of bone morphogenetic proteins (BMPs) in all aspects of embryonic development and organogenesis. Numerous genes encoding BMPs, BMP receptors, and their downstream signal transducers have been mutated in the mouse through targeted mutage... ... hiện toàn bộ
Tập 35 Số 1 - Trang 43-56 - 2003
Efficient, inducible Cre‐recombinase activation in vascular endotheliumAbstract In recent years, gene‐targeting studies in mice have elucidated many molecular mechanisms in vascular biology. However, it has been difficult to apply this approach to the study of postnatal animals because mutations affecting the vasculature are often embryonically lethal. We have therefore generated transgenic mice that express a tamoxifen‐inducible form ... ... hiện toàn bộ
Tập 46 Số 2 - Trang 74-80 - 2008
A CamKIIα iCre BAC allows brain‐specific gene inactivationAbstract Summary: We describe the generation of transgenic mouse lines expressing the Cre recombinase enzyme in brain under control of the CamKIIα gene present in a BAC expression vector. The CamKIIα BAC transgene gave a faithful expression pattern resembling the pattern of the endogenous CamKIIα gene. Specifically, high levels of CamKIIα Cre were detected in hippoc... ... hiện toàn bộ
Tập 31 Số 1 - Trang 37-42 - 2001
Generation of Pax2‐Cre mice by modification of a Pax2 bacterial artificial chromosomeAbstract Summary: The Pax2 gene is expressed in the developing otocyst, kidney, and midbrain–hindbrain boundary. We generated Pax2‐Cre transgenic lines by modification of a Pax2 bacterial artificial chromosome (BAC). In one Pax2‐Cre line, Cre mRNA starts to be expressed in the otic placode at the late presomite stage. R26R reporter mouse analysis revealed that the C... ... hiện toàn bộ
Tập 38 Số 4 - Trang 195-199 - 2004
Characterization of Notch3‐deficient mice: Normal embryonic development and absence of genetic interactions with a Notch1 mutationAbstract The Notch signaling pathway is an evolutionarily conserved signaling mechanism and mutations in its components disrupt cell fate specification and embryonic development in many organisms. To analyze the in vivo role of the Notch3 gene in mice, we created a deletion allele by gene targeting. Embryos homozygous for this mutation dev... ... hiện toàn bộ
Tập 37 Số 3 - Trang 139-143 - 2003