Genesis

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GAL4 system in drosophila: A fly geneticist's swiss army knife
Genesis - Tập 34 Số 1-2 - Trang 1-15 - 2002
Joseph B. Duffy
vavCre Transgenic mice: A tool for mutagenesis in hematopoietic and endothelial lineages
Genesis - Tập 34 Số 4 - Trang 251-256 - 2002
Pantelis Georgiades, Sarah Ogilvy, Hélène Duval, Diana R. Licence, D. Stephen Charnock‐Jones, S. K. Smith, Cristin G. Print
AbstractSummary: Cre transgenic mice can be used to delete gene sequences flanked by loxP sites in specific somatic tissues. We have generated vavCre transgenic mice, which can be used to inactivate genes specifically in adult hematopoietic and endothelial cells. In these animals, a Cre transgene is expressed under control of murine vav gene regulatory elements. To assess their usefulness, vavCre ... hiện toàn bộ
Long‐range effect of upd, a ligand for Jak/STAT pathway, on cell cycle in Drosophila eye development
Genesis - Tập 39 Số 2 - Trang 141-153 - 2004
Yu‐Chen Tsai, Y. Henry Sun
Abstractunpaired (upd) encodes a ligand for the Jak/STAT signaling pathway in Drosophila. In the second instar and early third larval eye disc, upd is expressed in the center of the posterior margin. upd loss‐of‐function mutations caused eye size reduction and upd overexpression caused eye enlargement. Upd regulates eye size through the Dome/Jak(Hop)/STAT92 signaling pathway to promote cell prolif... hiện toàn bộ
Generation of Pax2‐Cre mice by modification of a Pax2 bacterial artificial chromosome
Genesis - Tập 38 Số 4 - Trang 195-199 - 2004
Takahiro Ohyama, Andrew K. Groves
AbstractSummary: The Pax2 gene is expressed in the developing otocyst, kidney, and midbrain–hindbrain boundary. We generated Pax2‐Cre transgenic lines by modification of a Pax2 bacterial artificial chromosome (BAC). In one Pax2‐Cre line, Cre mRNA starts to be expressed in the otic placode at the late presomite stage. R26R reporter mouse analysis revealed that the Cre expression is sufficient to de... hiện toàn bộ
A fate map of Tbx1 expressing cells reveals heterogeneity in the second cardiac field
Genesis - Tập 45 Số 7 - Trang 470-475 - 2007
Tuong Huynh, Li Chen, Phillip Terrell, Antonio Baldini
AbstractTbx1 is required for the expansion of second heart field (SHF) cardiac progenitors destined to the outflow tract of the heart. Loss of Tbx1 causes heart defects in humans and mice. We report a novel Tbx1Cre knock‐in allele that we use to fate map Tbx1‐expressing cells during development in conjunction with a reporter and 3D image reconstruction. Tbx1 descendants constitute a mesodermal cel... hiện toàn bộ
Gain of function of Tbx1 affects pharyngeal and heart development in the mouse
Genesis - Tập 47 Số 3 - Trang 188-195 - 2009
Francesca Vitelli, Tuong Huynh, Antonio Baldini
AbstractMammalian development is highly sensitive to Tbx1 gene dosage reduction. Gene function insights can also be learned from increased or ectopic expression. The authors generated a novel mouse transgenic line, named COET, which expresses Tbx1 upon Cre‐mediated recombination. The authors crossed this transgenic line with Tbx1Cre animals to activate expression in the Tbx1‐expression domain. Com... hiện toàn bộ
Efficient recombination in pancreatic islets by a tamoxifen-inducible Cre-recombinase
Genesis - Tập 42 Số 3 - Trang 210-217 - 2005
Hongjie Zhang, Yoshio Fujitani, Christopher V.E. Wright, Maureen Gannon
Pdx‐1 knockdown reduces insulin promoter activity in zebrafish
Genesis - Tập 30 Số 3 - Trang 134-136 - 2001
Haigen Huang, Ning‐Ai Liu, Shuo Lin
Zebrafish pdx1 morphant displays defects in pancreas development and digestive organ chirality, and potentially identifies a multipotent pancreas progenitor cell
Genesis - Tập 30 Số 3 - Trang 137-140 - 2001
Nelson S. Yee, Shamila Yusuff, Michael Pack
A CamKIIα iCre BAC allows brain‐specific gene inactivation
Genesis - Tập 31 Số 1 - Trang 37-42 - 2001
Emilio Casanova, Sandra Fehsenfeld, Theo Mantamadiotis, Thomas Lemberger, Erich F. Greiner, Andrew F. Stewart, Günther Schütz
AbstractSummary: We describe the generation of transgenic mouse lines expressing the Cre recombinase enzyme in brain under control of the CamKIIα gene present in a BAC expression vector. The CamKIIα BAC transgene gave a faithful expression pattern resembling the pattern of the endogenous CamKIIα gene. Specifically, high levels of CamKIIα Cre were detected in hippocampus, cortex, and amygdala, and ... hiện toàn bộ
Tổng số: 39   
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