Genesis

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What cardiovascular defect does my prenatal mouse mutant have, and why?
Genesis - Tập 35 Số 1 - Trang 1-21 - 2003
Simon J. Conway, Agnieszka Kruzynska‐Frejtag, Paige L. Kneer, Michał Machnicki, Srinagesh V. Koushik
AbstractSummary: Since the advent of mouse targeted mutations, gene traps, an escalating use of a variety of complex transgenic manipulations, and large‐scale chemical mutagenesis projects yielding many mutants with cardiovascular defects, it has become increasingly evident that defects within the heart and vascular system are largely responsible for the observed i...... hiện toàn bộ
Molecular genetics of supernumerary tooth formation
Genesis - Tập 49 Số 4 - Trang 261-277 - 2011
Xiu‐Ping Wang, Jiabing Fan
AbstractDespite advances in the knowledge of tooth morphogenesis and differentiation, relatively little is known about the aetiology and molecular mechanisms underlying supernumerary tooth formation. A small number of supernumerary teeth may be a common developmental dental anomaly, while multiple supernumerary teeth usually have a genetic component and they are so...... hiện toàn bộ
GAL4 system in drosophila: A fly geneticist's swiss army knife
Genesis - Tập 34 Số 1-2 - Trang 1-15 - 2002
Joseph B. Duffy
vavCre Transgenic mice: A tool for mutagenesis in hematopoietic and endothelial lineages
Genesis - Tập 34 Số 4 - Trang 251-256 - 2002
Pantelis Georgiades, Sarah Ogilvy, Hélène Duval, Diana R. Licence, D. Stephen Charnock‐Jones, S. K. Smith, Cristin G. Print
AbstractSummary: Cre transgenic mice can be used to delete gene sequences flanked by loxP sites in specific somatic tissues. We have generated vavCre transgenic mice, which can be used to inactivate genes specifically in adult hematopoietic and endothelial cells. In these animals, a ... hiện toàn bộ
Long‐range effect of upd, a ligand for Jak/STAT pathway, on cell cycle in Drosophila eye development
Genesis - Tập 39 Số 2 - Trang 141-153 - 2004
Yu‐Chen Tsai, Y. Henry Sun
Abstractunpaired (upd) encodes a ligand for the Jak/STAT signaling pathway in Drosophila. In the second instar and early third larval eye disc, upd is expressed in the center of the posterior margin. upd loss‐of‐function mutations c...... hiện toàn bộ
Generation of Pax2‐Cre mice by modification of a Pax2 bacterial artificial chromosome
Genesis - Tập 38 Số 4 - Trang 195-199 - 2004
Takahiro Ohyama, Andrew K. Groves
AbstractSummary: The Pax2 gene is expressed in the developing otocyst, kidney, and midbrain–hindbrain boundary. We generated Pax2‐Cre transgenic lines by modification of a Pax2 bacterial artificial chromosome (BAC). In one Pax2‐Cre line, Cre mRNA starts to be expressed in the otic placode at the late presomite stage. R26R reporter mouse analysis revealed that the C...... hiện toàn bộ
A fate map of Tbx1 expressing cells reveals heterogeneity in the second cardiac field
Genesis - Tập 45 Số 7 - Trang 470-475 - 2007
Tuong Huynh, Li Chen, Phillip Terrell, Antonio Baldini
AbstractTbx1 is required for the expansion of second heart field (SHF) cardiac progenitors destined to the outflow tract of the heart. Loss of Tbx1 causes heart defects in humans and mice. We report a novel Tbx1Cre knock‐in allele that we use to fate map ... hiện toàn bộ
Gain of function of Tbx1 affects pharyngeal and heart development in the mouse
Genesis - Tập 47 Số 3 - Trang 188-195 - 2009
Francesca Vitelli, Tuong Huynh, Antonio Baldini
AbstractMammalian development is highly sensitive to Tbx1 gene dosage reduction. Gene function insights can also be learned from increased or ectopic expression. The authors generated a novel mouse transgenic line, named COET, which expresses Tbx1 upon Cre‐mediated recombination. The authors crossed this transge...... hiện toàn bộ
Efficient recombination in pancreatic islets by a tamoxifen-inducible Cre-recombinase
Genesis - Tập 42 Số 3 - Trang 210-217 - 2005
Hongjie Zhang, Yoshio Fujitani, Christopher V.E. Wright, Maureen Gannon
Pdx‐1 knockdown reduces insulin promoter activity in zebrafish
Genesis - Tập 30 Số 3 - Trang 134-136 - 2001
Haigen Huang, Ning‐Ai Liu, Shuo Lin
Tổng số: 39   
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