Long‐range effect of upd, a ligand for Jak/STAT pathway, on cell cycle in Drosophila eye development

Genesis - Tập 39 Số 2 - Trang 141-153 - 2004
Yu‐Chen Tsai1,2, Y. Henry Sun1,2
1Institute of Genetics, National Yang-Ming University, Taipei, Taiwan, Republic of China
2Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, Republic of China

Tóm tắt

Abstract

unpaired (upd) encodes a ligand for the Jak/STAT signaling pathway in Drosophila. In the second instar and early third larval eye disc, upd is expressed in the center of the posterior margin. upd loss‐of‐function mutations caused eye size reduction and upd overexpression caused eye enlargement. Upd regulates eye size through the Dome/Jak(Hop)/STAT92 signaling pathway to promote cell proliferation. Interestingly, the effect of Upd is only on cells located anterior to the morphogenetic furrow (MF), but has no effect on the second mitotic wave, which is posterior to MF. Overexpression of upd behind MF can nonautonomously induce cell proliferation up to 20 rows of cells anterior to MF. The G1 cyclin, cycD transcript level was also enhanced anterior to MF. Consistent with the long‐range effect, we found that the extracellular Upd protein can be detected over a comparable long range, suggesting that Upd acts directly over a long distance as a signaling molecule. genesis 39:141–153, 2004. © 2004 Wiley‐Liss, Inc.

Từ khóa


Tài liệu tham khảo

10.1016/S1534-5807(03)00244-2

Bach EA, 2003, A sensitized genetic screen to identify novel regulators and components of the Drosophila janus kinase/signal transducer and activator of transcription pathway, Genetics, 165, 1149, 10.1093/genetics/165.3.1149

10.1016/S0092-8674(01)00266-5

10.1073/pnas.171302098

10.1101/gad.8.3.300

10.1006/dbio.1996.0038

10.1016/0092-8674(95)90291-0

10.1016/S0960-9822(01)00524-3

10.1242/dev.00535

10.1101/gad.955202

10.1016/S1534-5807(03)00024-8

Chern JJ, 2002, Lobe mediates Notch signaling to control domain‐specific growth in the Drosophila eye disc, Development, 129, 4005, 10.1242/dev.129.17.4005

10.1126/science.277.5332.1630

10.1093/emboj/19.17.4543

10.1038/24402

10.1101/gad.11.1.94

10.1038/417299a

10.1038/43213

10.1073/pnas.93.7.3011

10.1016/S0092-8674(00)81385-9

10.1007/BF00272212

10.1242/dev.125.11.2031

10.1126/science.7892602

10.1101/gad.12.20.3252

10.1016/S0092-8674(03)00557-9

10.1073/pnas.96.2.564

10.1242/dev.120.8.2121

Heberlein U, 1991, Cell‐fate determination in the developing Drosophila eye: role of the rough gene, Development, 112, 703, 10.1242/dev.112.3.703

10.1016/S0960-9822(02)01057-6

10.1242/dev.125.24.5069

10.1016/S0092-8674(00)81286-6

10.1016/S1534-5807(02)00376-3

10.1242/dev.124.4.761

Juni N, 1996, The Om (1E) mutation in Drosophila ananassae causes compound eye overgrowth due to tom retrotransposon‐driven overexpression of a novel gene, Genetics, 143, 1257, 10.1093/genetics/143.3.1257

10.1242/dev.00168

10.1016/S1534-5807(03)00328-9

Lindsley DLaZGG, 1992, The genome of Drosophila melanogaster

10.1006/dbio.1999.9390

10.1093/emboj/18.5.1367

10.1016/S0378-1119(99)00033-5

10.1007/s000180050394

10.1038/43219

10.1038/287795a0

10.1101/gad.12.3.435

10.1126/science.275.5297.203

10.1126/science.7914031

10.1016/0012-1606(76)90225-6

10.1016/S0925-4773(97)00127-5

10.1038/35016119

10.1016/S0092-8674(01)00607-9

Staehling‐Hampton K, 1994, Specificity of bone morphogenetic protein‐related factors: cell fate and gene expression changes in Drosophila embryos induced by decapentaplegic but not 60A, Cell Growth Differ, 5, 585

10.1038/43206

10.1016/S0960-9822(00)00378-X

10.1093/genetics/141.3.1075

10.1002/gene.10135

10.1007/BF00291041

10.1016/0092-8674(94)90440-5

10.1016/0012-1606(88)90067-X

10.1126/science.1066700

10.1016/S0959-437X(00)00119-2

10.1242/dev.113.3.841

10.1016/S1534-5807(02)00412-4

10.1073/pnas.93.12.5842

10.1016/S0092-8674(00)81287-8

10.1242/dev.126.24.5857

10.1016/S0960-9822(00)80081-0

10.1101/gad.13.10.1342

Thông tin
Thông tin xuất bản

Genesis

Tập 39 Số 2

141-153

Thông tin tác giả