Genes to Cells
SCIE-ISI SCOPUS (1996-2025)
1365-2443
1356-9597
Anh Quốc
Cơ quản chủ quản: Wiley-Blackwell Publishing Ltd , WILEY
Lĩnh vực:
GeneticsCell BiologyMedicine (miscellaneous)
Các bài báo tiêu biểu
Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution
Tập 16 Số 2 - Trang 123-140 - 2011
AAA+ superfamily ATPases: common structure–diverse function
Tập 6 Số 7 - Trang 575-597 - 2001
The AAA+ superfamily of ATPases, which contain a homologous ATPase module, are
found in all kingdoms of living organisms where they participate in diverse
cellular processes including membrane fusion, proteolysis and DNA replication.
Recent structural studies have revealed that they usually form ring‐shaped
oligomers, which are crucial for their ATPase activities and mechanisms of
action. These ri...
Maintenance of self‐renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b
Tập 11 Số 7 - Trang 805-814 - 2006
DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b cooperatively regulate cytosine
methylation in CpG dinucleotides in mammalian genomes, providing an epigenetic
basis for gene silencing and maintenance of genome integrity. Proper CpG
methylation is required for the normal growth of various somatic cell types,
indicating its essential role in the basic cellular function of mammalian cells.
Previous s...
The superoxide‐producing NAD(P)H oxidase Nox4 in the nucleus of human vascular endothelial cells
Tập 10 Số 12 - Trang 1139-1151 - 2005
The superoxide‐producing NAD(P)H oxidase Nox4 was initially identified as an
enzyme that is highly expressed in the kidney and is possibly involved in oxygen
sensing and cellular senescence. Although the oxidase is also abundant in
vascular endothelial cells, its role remains to be elucidated. Here we show that
Nox4 preferentially localizes to the nucleus of human umbilical vein endothelial
cells ...
Initiation of Sendai virus multiplication from transfected cDNA or RNA with negative or positive sense
Tập 1 Số 6 - Trang 569-579 - 1996
Background: The mononegavirus superfamily (Mononegavirales) comprises three
families, Rhabdoviridae, Paramyxoviridae and Filoviridae. These viruses possess
a single stranded negative sense RNA as the genome. Recent success in the
recovery of infectious virus from a transfected cDNA of mononegaviruses
including Sendai virus, a prototypic paramyxovirus, is opening the possibility
of their genetic en...
The shortest path from the surface to the nucleus: RBP‐Jκ/Su(H) transcription factor
Tập 1 Số 1 - Trang 1-9 - 1996
Communication between cell surface receptors and nuclear transcription factors
is of primary importance to multicellular organisms. Since there are numerous
molecules involved in this process, their mutual interaction forms complex
networks of informational regulation, which is still under extensive
investigation. The RBP‐Jκ transcription factor interacts directly with the Notch
receptor involved ...
MBSJ MCC Young Scientist Award 2009 REVIEW: Selective autophagy regulates various cellular functions
Tập 15 Số 9 - Trang 923-933 - 2010
Autophagy is a self‐eating system conserved among eukaryotes, in which cellular
components including organelles are entrapped into a double membrane structure
called the autophagosome and then degraded by lysosomal hydrolases. In addition
to its role in supplying amino acids in response to nutrient starvation,
autophagy is involved in quality control to maintain cell health. Thus,
inactivation of ...
Role of p300, a transcriptional coactivator, in signalling of TGF‐β
Tập 3 Số 9 - Trang 613-623 - 1998
BackgroundSmad proteins are novel transcriptional regulators mediating the
signalling of the transforming growth factor‐β (TGF‐β) superfamily. Coactivators
such as p300/CBP promote transactivation by various transcription factors
through a direct interaction with them. Adenoviral oncoprotein E1A, which binds
p300, was shown to inhibit the signalling of TGF‐β. These findings raise the
possibility t...
Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres
Tập 3 Số 12 - Trang 801-810 - 1998
Background: Activating transcription factor‐4 (ATF4)—also termed CREB2, C/ATF,
and TAXREB67—is a basic‐leucine zipper (bZip) transcription factor that belongs
to the ATF/CREB family. In addition to its own family members, ATF4 can also
form heterodimers with other related but distinct bZIP proteins such as the
C/EBP, AP‐1 and Maf families, which may give rise to a variety of combinatorial
diversit...
Roles of Sall4 in the generation of pluripotent stem cells from blastocysts and fibroblasts
Tập 14 Số 6 - Trang 683-694 - 2009
Pluripotency of embryonic stem (ES) cells is maintained by a network consisting
of multiple transcription factors, including Oct3/4, Sox2, Nanog, Klf4 and
Sall4. Among these factors, the forced expressions of Oct3/4, Sox2 and Klf4 are
sufficient to reprogram fibroblasts into induced pluripotent stem (iPS) cells.
The current study analyzed the role of Sall4 during the generation of ES cells
and iPS...