Genes to Cells
SCIE-ISI SCOPUS (1996-2023)
1365-2443
1356-9597
Anh Quốc
Cơ quản chủ quản: Wiley-Blackwell Publishing Ltd , WILEY
Lĩnh vực:
GeneticsCell BiologyMedicine (miscellaneous)
Các bài báo tiêu biểu
Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution
Tập 16 Số 2 - Trang 123-140 - 2011
AAA+ superfamily ATPases: common structure–diverse functionThe AAA+ superfamily of ATPases, which contain a homologous ATPase module, are found in all kingdoms of living organisms where they participate in diverse cellular processes including membrane fusion, proteolysis and DNA replication. Recent structural studies have revealed that they usually form ring‐shaped oligomers, which are crucial for their ATPase activities and m... ... hiện toàn bộ
Tập 6 Số 7 - Trang 575-597 - 2001
Maintenance of self‐renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3bDNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b cooperatively regulate cytosine methylation in CpG dinucleotides in mammalian genomes, providing an epigenetic basis for gene silencing and maintenance of genome integrity. Proper CpG methylation is required for the normal growth of various somatic cell types, indicating its essential role in the basic cellular function of mammalian cells. Pr... ... hiện toàn bộ
Tập 11 Số 7 - Trang 805-814 - 2006
The superoxide‐producing NAD(P)H oxidase Nox4 in the nucleus of human vascular endothelial cellsThe superoxide‐producing NAD(P)H oxidase Nox4 was initially identified as an enzyme that is highly expressed in the kidney and is possibly involved in oxygen sensing and cellular senescence. Although the oxidase is also abundant in vascular endothelial cells, its role remains to be elucidated. Here we show that Nox4 preferentially localizes to the nucleus of human umbilical vein endothelia... ... hiện toàn bộ
Tập 10 Số 12 - Trang 1139-1151 - 2005
Initiation of Sendai virus multiplication from transfected cDNA or RNA with negative or positive sense Background : The mononegavirus superfamily (Mononegavirales) comprises three families, Rhabdoviridae , Paramyxoviridae and Filoviridae . These viruses possess a single stranded negative sense RNA as the genome. Recent success in the recovery of infectious virus from a transfected cDNA ... ... hiện toàn bộ
Tập 1 Số 6 - Trang 569-579 - 1996
The shortest path from the surface to the nucleus: RBP‐Jκ/Su(H) transcription factorCommunication between cell surface receptors and nuclear transcription factors is of primary importance to multicellular organisms. Since there are numerous molecules involved in this process, their mutual interaction forms complex networks of informational regulation, which is still under extensive investigation. The RBP‐Jκ transcription factor interacts directly with the Notch receptor i... ... hiện toàn bộ
Tập 1 Số 1 - Trang 1-9 - 1996
MBSJ MCC Young Scientist Award 2009 REVIEW: Selective autophagy regulates various cellular functionsAutophagy is a self‐eating system conserved among eukaryotes, in which cellular components including organelles are entrapped into a double membrane structure called the autophagosome and then degraded by lysosomal hydrolases. In addition to its role in supplying amino acids in response to nutrient starvation, autophagy is involved in quality control to maintain cell health. Thus, inactiva... ... hiện toàn bộ
Tập 15 Số 9 - Trang 923-933 - 2010
Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres Background : Activating transcription factor‐4 (ATF4)—also termed CREB2, C/ATF, and TAXREB67—is a basic‐leucine zipper (bZip) transcription factor that belongs to the ATF/CREB family. In addition to its own family members, ATF4 can also form heterodimers with other related but distinct bZIP proteins such as the C/EBP, AP‐1 and Maf families, which may give rise to... ... hiện toàn bộ
Tập 3 Số 12 - Trang 801-810 - 1998
Role of p300, a transcriptional coactivator, in signalling of TGF‐βBackground Smad proteins are novel transcriptional regulators mediating the signalling of the transforming growth factor‐β (TGF‐β) superfamily. Coactivators such as p300/CBP promote transactivation by various transcription factors through a direct interaction with them. Adenoviral oncoprotein E1A, which binds p300, was shown to inhibit the signalling of TG...
Tập 3 Số 9 - Trang 613-623 - 1998
Roles of Sall4 in the generation of pluripotent stem cells from blastocysts and fibroblastsPluripotency of embryonic stem (ES) cells is maintained by a network consisting of multiple transcription factors, including Oct3/4, Sox2, Nanog, Klf4 and Sall4. Among these factors, the forced expressions of Oct3/4, Sox2 and Klf4 are sufficient to reprogram fibroblasts into induced pluripotent stem (iPS) cells. The current study analyzed the role of Sall4 during the generation of ES cells... ... hiện toàn bộ
Tập 14 Số 6 - Trang 683-694 - 2009