Genes to Cells

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Roles of Sall4 in the generation of pluripotent stem cells from blastocysts and fibroblasts
Genes to Cells - Tập 14 Số 6 - Trang 683-694 - 2009
Noriko Tsubooka, Tomoko Ichisaka, Keisuke Okita, Kazutoshi Takahashi, Masato Nakagawa, Shinya Yamanaka
Pluripotency of embryonic stem (ES) cells is maintained by a network consisting of multiple transcription factors, including Oct3/4, Sox2, Nanog, Klf4 and Sall4. Among these factors, the forced expressions of Oct3/4, Sox2 and Klf4 are sufficient to reprogram fibroblasts into induced pluripotent stem (iPS) cells. The current study analyzed the role of Sall4 during the generation of ES cells and iPS... hiện toàn bộ
Architectural flexibility in lambda site‐specific recombination: three alternate conformations channel the attL site into three distinct pathways
Genes to Cells - Tập 1 Số 5 - Trang 453-463 - 1996
Anca M. Segall, Howard A. Nash
Background:  In the phage lambda life cycle, the Integrase (Int) protein carries out recombination between two different sets of DNA substrates: attP and attB in integration, attL and attR in excision. In each case, the partners are very different in structure from each other and the recombination reaction between them is effectively irreversible. For comparison, we have studied the recombination ... hiện toàn bộ
Competition between a noncoding exon and introns: Gomafu contains tandem UACUAAC repeats and associates with splicing factor-1
Genes to Cells - Tập 16 Số 5 - Trang 479-490 - 2011
Hitomi Tsuiji, Rei Yoshimoto, Yūko Hasegawa, Masaaki Furuno, Minoru Yoshida, Shinichi Nakagawa
MST1‐JNK promotes apoptosis via caspase‐dependent and independent pathways
Genes to Cells - Tập 6 Số 6 - Trang 519-530 - 2001
Seiji Ura, Norihisa Masuyama, Jonathan D. Graves, Yukiko Gotoh
Background MST1 is an upstream kinase of the JNK and p38 MAPK pathways whose expression induces apoptotic morphological changes such as nuclear condensation. During apoptosis, caspase cleavage of MST1 removes a C‐terminal regulatory domain, increasing the kinase activity of the MST1 N‐terminal domain. Downstream pathways of MST1 in the induction of apoptosis remain to be clarified. Results In this... hiện toàn bộ
Densin‐180, a synaptic protein, links to PSD‐95 through its direct interaction with MAGUIN‐1
Genes to Cells - Tập 7 Số 11 - Trang 1149-1160 - 2002
Kazuhiro Ohtakara, Miwako Nishizawa, Ichiro Izawa, Yutaka Hata, Satoshi Matsushima, Waro Taki, Hiroyasu Inada, Yoshimi Takai, Masaki Inagaki
AbstractBackground: Densin‐180, a brain‐specific protein highly concentrated at the postsynaptic density (PSD), belongs to the LAP [leucine‐rich repeats and PSD‐95/Dlg‐A/ZO‐1 (PDZ) domains] family of proteins, some of which play fundamental roles in the establishment of cell polarity.Results: To identify new Densin‐180‐interacting proteins, we screened a yeast two‐hybrid library using the COOH‐ter... hiện toàn bộ
Attenuation of cell motility observed with high doses of sphingosine 1‐phosphate or phosphorylated FTY720 involves RGS2 through its interactions with the receptor S1P
Genes to Cells - Tập 13 Số 7 - Trang 747-757 - 2008
Takayuki Kohno, Yasuyuki Igarashi
Sphingosine 1‐phosphate (S1P) stimulation enhances cell motility via the G‐protein coupled S1P receptor S1P1. This ligand‐induced, receptor‐mediated cell motility follows a typical bell‐shaped dose–response curve, that is, stimulation with low concentrations of S1P enhances cell motility, whereas excess ligand stimulation does not enhance it. So far, the attenuation of the response at higher ligan... hiện toàn bộ
Maintenance of self‐renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b
Genes to Cells - Tập 11 Số 7 - Trang 805-814 - 2006
Akiko Tsumura, Tomohiro Hayakawa, Yuichi Kumaki, Shin‐ichiro Takebayashi, Masaki Sakaue, Chisa Matsuoka, Kunitada Shimotohno, Fuyuki Ishikawa, En Li, Hiroki R. Ueda, Jun‐ichi Nakayama, Masaki Okano
DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b cooperatively regulate cytosine methylation in CpG dinucleotides in mammalian genomes, providing an epigenetic basis for gene silencing and maintenance of genome integrity. Proper CpG methylation is required for the normal growth of various somatic cell types, indicating its essential role in the basic cellular function of mammalian cells. Previous s... hiện toàn bộ
MutT‐related error avoidance mechanism for DNA synthesis
Genes to Cells - Tập 1 Số 2 - Trang 139-145 - 1996
Mutsuo Sekiguchi
Mutator mutants that show an increased frequency of spontaneous mutation have led to the elucidation of the multiple pathways of spontaneous mutagenesis. 8‐Oxo‐dGTP (8‐oxo‐7,8‐dihydrodeoxyguanosine triphosphate) is formed in the nucleotide pool of a cell during normal cellular metabolism, and when it is incorporated into DNA causes mutation. MutT protein of Escherichia coli and related mammalian e... hiện toàn bộ
Condensin function at centromere chromatin facilitates proper kinetochore tension and ensures correct mitotic segregation of sister chromatids
Genes to Cells - Tập 12 Số 9 - Trang 1075-1090 - 2007
Vladimir Yong‐Gonzalez, Bi‐Dar Wang, Pavel Butylin, Ilia I. Ouspenski, Alexander Strunnikov
The condensin complex is essential for sister chromatid segregation in eukaryotic mitosis. Nevertheless, in budding yeast, condensin mutations result in massive mis‐segregation of chromosomes containing the nucleolar organizer, while other chromosomes, which also contain condensin binding sites, remain genetically stable. To investigate this phenomenon we analyzed the mechanism of the cell‐cycle a... hiện toàn bộ
AAA+ superfamily ATPases: common structure–diverse function
Genes to Cells - Tập 6 Số 7 - Trang 575-597 - 2001
Teru Ogura, Anthony J. Wilkinson
The AAA+ superfamily of ATPases, which contain a homologous ATPase module, are found in all kingdoms of living organisms where they participate in diverse cellular processes including membrane fusion, proteolysis and DNA replication. Recent structural studies have revealed that they usually form ring‐shaped oligomers, which are crucial for their ATPase activities and mechanisms of action. These ri... hiện toàn bộ
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