Genes to Cells

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MBSJ MCC Young Scientist Award 2009 REVIEW: Selective autophagy regulates various cellular functions
Genes to Cells - Tập 15 Số 9 - Trang 923-933 - 2010
Masaaki Komatsu, Yoshinobu Ichimura
Autophagy is a self‐eating system conserved among eukaryotes, in which cellular components including organelles are entrapped into a double membrane structure called the autophagosome and then degraded by lysosomal hydrolases. In addition to its role in supplying amino acids in response to nutrient starvation, autophagy is involved in quality control to maintain cell health. Thus, inactiva...... hiện toàn bộ
The superoxide‐producing NAD(P)H oxidase Nox4 in the nucleus of human vascular endothelial cells
Genes to Cells - Tập 10 Số 12 - Trang 1139-1151 - 2005
Junya Kuroda, Kazunori Nakagawa, Tomoko Yamasaki, Kei‐ichiro Nakamura, Ryu Takeya, Futoshi Kuribayashi, Shinobu Imajoh‐Ohmi, Kazuhiko Igarashi, Yosaburo Shibata, Katsuo Sueishi, Hideki Sumimoto
The superoxide‐producing NAD(P)H oxidase Nox4 was initially identified as an enzyme that is highly expressed in the kidney and is possibly involved in oxygen sensing and cellular senescence. Although the oxidase is also abundant in vascular endothelial cells, its role remains to be elucidated. Here we show that Nox4 preferentially localizes to the nucleus of human umbilical vein endothelia...... hiện toàn bộ
Membrane lipid saturation activates IRE1α without inducing clustering
Genes to Cells - Tập 18 Số 9 - Trang 798-809 - 2013
Yuto Kitai, Hiroyuki Ariyama, Nozomu Kono, Daisuke Oikawa, Takao Iwawaki, Hiroyuki Arai
The unfolded protein response (UPR) is an adaptive stress response that responds to the accumulation of unfolded proteins in the lumen of the endoplasmic reticulum (ER) and that adjusts the protein‐folding capacity to the needs of the cell. Perturbation of cellular li...... hiện toàn bộ
COUP‐TFII regulates the functions of Prox1 in lymphatic endothelial cells through direct interaction
Genes to Cells - Tập 14 Số 3 - Trang 425-434 - 2009
Tomoko Yamazaki, Yasuhiro Yoshimatsu, Yasuyuki Morishita, Kohei Miyazono, Tetsuro Watabe
During embryonic lymphatic development, Prox1 homeobox transcription factor is expressed in a subset of venous blood vascular endothelial cells (BECs) in which COUP‐TFII orphan nuclear receptor is highly expressed. Prox1 induces differentiation of BECs into lymphatic endothelial cells (LECs) by inducing the expression of various LEC markers including vascular endothelial growth factor rece...... hiện toàn bộ
Control of body size in C. elegans dependent on food and insulin/IGF-1 signal
Genes to Cells - Tập 16 Số 6 - Trang 639-651 - 2011
Shuhei So, Kohji Miyahara, Yasumi Ohshima
Aurora C is directly associated with Survivin and required for cytokinesis
Genes to Cells - Tập 10 Số 6 - Trang 617-626 - 2005
Xiaomei Yan, Lihuan Cao, Qiang Li, Yanhua Wu, Haoxing Zhang, Hexige Saiyin, Xiang-hua Liu, Xuqing Zhang, Qinghua Shi, Long Yu
Much recent attention has been focused on Aurora C, the third member of the mammalian Aurora kinases family that plays significant roles in mitosis. We report here that using sensitive RT‐PCR to amplify the C‐terminal, we found that Aurora C is not only expressed highly in testis, but also among 16 other human tissues in a broad‐spectrum way. Aurora C, as a chromosomal passenger protein, i...... hiện toàn bộ
Densin‐180, a synaptic protein, links to PSD‐95 through its direct interaction with MAGUIN‐1
Genes to Cells - Tập 7 Số 11 - Trang 1149-1160 - 2002
Kazuhiro Ohtakara, Miwako Nishizawa, Ichiro Izawa, Yutaka Hata, Satoshi Matsushima, Waro Taki, Hiroyasu Inada, Yoshimi Takai, Masaki Inagaki
AbstractBackground: Densin‐180, a brain‐specific protein highly concentrated at the postsynaptic density (PSD), belongs to the LAP [leucine‐rich repeats and PSD‐95/Dlg‐A/ZO‐1 (PDZ) domains] family of proteins, some of which play fundamental roles in the establishment of cell polarity.Results: To identif...... hiện toàn bộ
MST1‐JNK promotes apoptosis via caspase‐dependent and independent pathways
Genes to Cells - Tập 6 Số 6 - Trang 519-530 - 2001
Seiji Ura, Norihisa Masuyama, Jonathan D. Graves, Yukiko Gotoh
Background MST1 is an upstream kinase of the JNK and p38 MAPK pathways whose expression induces apoptotic morphological changes such as nuclear condensation. During apoptosis, caspase cleavage of MST1 removes a C‐terminal regulatory domain, increasing the kinase activity of the MST1 N‐terminal domain. Downstream pathways of MST1 in the induction of apoptosis remain t...... hiện toàn bộ
Alternative splicing ofMef2cpromoted by Fox‐1 during neural differentiation in P19 cells
Genes to Cells - Tập 15 Số 3 - Trang 255-267 - 2010
Nor Hakimah Ab Hakim, Toshiki Kounishi, AHM Khurshid Alam, Toshifumi Tsukahara, Hitoshi Suzuki
Mef2c protein is one of the MADS‐box type transcription factors involved in muscular differentiation and synaptic formation. Previously, it has been reported that theMef2cgene is responsible for three alternative splicing regulations. Here, we investigated the alternative splicing variants ofMef2cduring neural differentiation of P19 cel...... hiện toàn bộ
Identification of target genes for the CDK subunits of the Mediator complex
Genes to Cells - Tập 16 Số 12 - Trang 1208-1218 - 2011
Taiki Tsutsui, Rikiya Fukasawa, Aki Tanaka, Yutaka Hirose, Yoshiaki Ohkuma
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