Efficient in vivo delivery of DNA to pulmonary cells using the novel lipid EDMPCGene Therapy - Tập 4 - Trang 983-992 - 1997
CM Gorman, M Aikawa, B Fox, E Fox, C Lapuz, B Michaud, H Nguyen, E Roche, T Sawa, JP Wiener-Kronish
We compared the efficacy of gene transfer in vitro and in vivo using various formulations of DNA–lipid complexes based on the novel cationic lipid EDMPC (1,2-dimyristoyl-sn-glycero-3-ethylphosphocholine, chloride salt). In vitro studies analyzed delivery of marker genes to four established cell lines, including two of pulmonary origin. The in vivo analysis used intralobar delivery of marker genes ...... hiện toàn bộ