Targeted cancer immunotherapy with oncolytic adenovirus coding for a fully human monoclonal antibody specific for CTLA-4Gene Therapy - Tập 19 Số 10 - Trang 988-998 - 2012
João D. Dias, Otto Hemminki, Ioan Diaconu, Mari Hirvinen, Kosuke Hashimoto, Kilian Guse, Sophie Escutenaire, Anna Kanerva, Saila K. Pesonen, Angelica Loskog, Vincenzo Cerullo, Akseli Hemminki
Modulation of TNFα, a determinant of acute toxicity associated with systemic delivery of first-generation and helper-dependent adenoviral vectorsGene Therapy - Tập 13 Số 17 - Trang 1272-1280 - 2006
Vaishali R. Mane, Gabriele Toietta, William M. McCormack, Ian Del Conde, Christian Clarke, Donna Palmer, Milton J. Finegold, Lucio Pastore, Robin J. Parks, Job E. López, Brendan Lee
Efficient in vivo delivery of DNA to pulmonary cells using the novel lipid EDMPCGene Therapy - Tập 4 - Trang 983-992 - 1997
CM Gorman, M Aikawa, B Fox, E Fox, C Lapuz, B Michaud, H Nguyen, E Roche, T Sawa, JP Wiener-Kronish
We compared the efficacy of gene transfer in vitro and in vivo using various formulations of DNA–lipid complexes based on the novel cationic lipid EDMPC (1,2-dimyristoyl-sn-glycero-3-ethylphosphocholine, chloride salt). In vitro studies analyzed delivery of marker genes to four established cell lines, including two of pulmonary origin. The in vivo analysis used intralobar delivery of marker genes ...... hiện toàn bộ