Risks and Benefits of Gene Therapy for Immunodeficiency: a Reality Check
Tóm tắt
Từ khóa
Tài liệu tham khảo
Cavazzano-Calvo M et al. Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease Science 2000 288: 669–672
Hacein-Bey-Abina S et al. Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy N Engl J Med 2002 346: 1185–1193
Elleder D, Pavlicek A, Paces J, Hejnar J . Preferential integration of human immunodeficiency virus type 1 into genes, cytogenetic R bands and GC-rich DNA regions: insight from the human genome sequence FEBS Lett 2002 517: 285–286
Schroder AR et al. HIV-1 integration in the human genome favors active genes and local hotspots Cell 2002 110: 521–529
Scherdin U, Rhodes K, Breindl M . Transcriptionally active genome regions are preferred targets for retrovirus integration J Virol 1990 64: 907–912
Weidhaas JB, Angelichio EL, Fenner S, Coffin JM . Relationship between retroviral DNA integration and gene expression J Virol 2000 74: 8382–8389
Ortiz-Urda S et al. Stable nonviral genetic correction of inherited human skin disease Nat Med 2002 8: 1166–1170