LPD lipopolyplex initiates a potent cytokine response and inhibits tumor growth

Gao X, Huang L . Potentiation of cationic liposome-mediated gene delivery by polycations Biochemistry 1996 35: 1027–1036

Sorgi FL, Bhattacharya S, Huang L . Protamine sulfate enhances lipid-mediated gene transfer Gene Therapy 1997 4: 961–968

Li S, Huang L . In vivo gene transfer via intravenous administration of cationic lipid-protamine-DNA (LPD) complexes Gene Therapy 1997 4: 891–900

Li S, Rizzo M, Bhattacharya S, Huang L . Characterization of cationic lipid-protamine-DNA (LPD) complexes for intravenous gene delivery Gene Therapy 1998 5: 930–937

Li S et al. Effect of immune response on gene transfer to the lung via systemic administration of cationic lipidic vectors Am J Physiol 1999 276: L796–L804

Song YK, Liu F, Chu S, Liu D . Characterization of cationic liposome-mediated gene transfer in vivo by intravenous administration Hum Gene Ther 1997 8: 1585–1594

Irvine KR et al. Enhancing efficacy of recombinant anticancer vaccines with prime/boost regimens that use two different vectors J Nat Cancer Inst 1997 89: 1595–1601

Nakaichi M, Takeuchi A, Shitara N, Takakura K . The antitumor activity of the DNA fraction from Mycobacterium bovis BCG (MY-1) for glioblastoma J Vet Med Sci 1995 57: 583–585

Krieg AM, Love-Homan L, Yi AK, Harty JT . CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge J Immunol 1998 161: 2428–2434

Sparwasser T et al. Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-alpha-mediated shock Eur J Immunol 1997 27: 1671–1679

Conry RM et al. Selected strategies to augment polynucleotide immunization Gene Therapy 1996 3: 67–74

Hurpin C et al. The mode of presentation and route of administration are critical for the induction of immune responses to p53 and antitumor immunity Vaccine 1998 16: 208–215

Parker SE et al. Plasmid DNA gene therapy: studies with the human interleukin-2 gene in tumor cells in vitro and in the murine B16 melanoma model in vivo Cancer Gene Ther 1996 3: 175–185.

Freimark BD et al. Cationic lipids enhance cytokine and cell influx levels in the lung following administration of plasmid: cationic lipid complexes J Immunol 1998 160: 4580–4586

Schwartz DA et al. CpG motifs in bacterial DNA cause inflammation in the lower respiratory tract J Clin Invest 1997 100: 68–73.

Krieg AM . Lymphocyte activation by CpG dinucleotide motifs in prokaryotic DNA Trends Microbiol 1996 4: 73–76

Stacey KJ, Sweet MJ, Hume DA . Macrophages ingest and are activated by bacterial DNA J Immunol 1996 157: 2116–2122

Jakob T et al. Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: a role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA J Immunol 1998 161: 3042–3049

Sparwasser T et al. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells Eur J Immunol 1998 28: 2045–2054

Klinman DM et al. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma Proc Nat Acad Sci USA 1996 93: 2879–2883

Yi AK, Chace JH, Cowdery JS, Krieg AM . IFN-gamma promotes IL-6 and IgM secretion in response to CpG motifs in bacterial DNA and oligodeoxynucleotides J Immunol 1996 156: 558–564

Ballas ZK, Rasmussen WL, Krieg AM . Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA J Immunol 1996 157: 1840–1845

Chace JH et al. Bacterial DNA-induced NK cell IFN-gamma production is dependent on macrophage secretion of IL-12 Clin Immunol Immunopathol 1997 84: 185–193

He Y, Huang L . Growth inhibition of human papillomavirus 16 DNA-positive mouse tumor by antisense RNA transcribed from U6 promoter Cancer Res 1997 57: 3993–3999

Hofland H, Huang L . Inhibition of human ovarian carcinoma cell proliferation by liposome–plasmid DNA complex Biochem Biophys Res Commun 1995 207: 492–496

Sweet MJ et al. IFN-gamma primes macrophage responses to bacterial DNA J Inter Cytok Res 1998 18: 263–271

Lew D et al. Cancer gene therapy using plasmid DNA: pharmacokinetic study of DNA following injection in mice (see comments) Hum Gene Ther 1995 6: 553–564

Cowdery JS, Chace JH, Yi AK, Krieg AM . Bacterial DNA induces NK cells to produce IFN-gamma in vivo and increases the toxicity of lipopolysaccharides J Immunol 1996 156: 4570–4575.

Yu A et al. RB-mediated suppression of spontaneous multiple neuroendocrine neoplasia and lung metastases in Rb+/− mice Proc Nat Acad Sci USA 1999 96: 3916–3921

Lui Y et al. Systemic gene delivery expands the repertoire of effective antiangiogenic agents J Biol Chem 1999 274: 13338–13344.

Gorelik E, Peppoloni S, Overton R, Herberman RB . Increase in H-2 antigen expression and immunogenicity of BL6 melanoma cells treated with N-methyl-N′-nitronitrosoguanidine Cancer Res 1985 45: 5341–5347

Gorelik E, Gunji Y, Herberman RB . H-2 antigen expression and sensitivity of BL6 melanoma cells to natural killer cell cytotoxicity J Immunol 1988 140: 2096–2102

De Bruijn ML et al. Immunization with human papillomavirus type 16 (HPV16) oncoprotein-loaded dendritic cells as well as protein in adjuvant induces MHC class I-restricted protection to HPV16-induced tumor cells Cancer Res 1998 58: 724–731

Ressing ME et al. Human CTL epitopes encoded by human papillomavirus type 16 E6 and E7 identified through in vivo and in vitro immunogenicity studies of HLA-A*0201-binding peptides J Immunol 1995 154: 5934–5943

Feltkamp MC et al. Cytotoxic T lymphocytes raised against a subdominant epitope offered as a synthetic peptide eradicate human papillomavirus type 16-induced tumors Eur J Immunol 1995 25: 2638–2642

Hwu P et al. In vivo antitumor activity of T cells redirected with chimeric antibody/T-cell receptor genes Cancer Res 1995 55: 3369–3373.

Tuting T, Storkus W, Lotze M . Gene-based strategies for the immunotherapy of cancer J Mol Med 1997 75: 478–491

Maini A et al. New developments in the use of cytokines for cancer therapy Anticancer Res 1997 17: 3803–3808

Brazolot Millan CL et al. CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice Proc Nat Acad Sci USA 1998 95: 15553–15558

He YK et al. Potentiation of E7 antisense RNA-induced antitumor immunity by co-delivery of IL-12 gene in HPV16 DNA-positive mouse tumor Gene Therapy 1998 5: 1462–1471

Robbins PD, Tahara H, Ghivizzani SC . Viral vectors for gene therapy Trends Biotechnol 1998 16: 35–40

Liu Y et al. Cationic liposome-mediated intravenous gene delivery J Biol Chem 1995 270: 24864–24870

Stiles BG, Bavari S, Krakauer T, Ulrich RG . Toxicity of staphylococcal enterotoxins potentiated by lipopolysaccharide: major histocompatibility complex class II molecule dependency and cytokine release Infect Immun 1993 61: 5333–5338

Hinshaw LB et al. Lethal Staphylococcus aureus-induced shock in primates: prevention of death with anti-TNF antibody J Trauma 1992 33: 568–573

Freudenberg MA, Galanos C . Tumor necrosis factor alpha mediates lethal activity of killed gram-negative and gram-positive bacteria in D-galactosamine-treated mice Infect Immun 1991 59: 2110–2115

Templeton NS et al. Improved DNA: liposome complexes for increased systemic delivery and gene expression Nat Biotechnol 1997 15: 647–652

Shiloni E et al. Retroviral transduction of interferon-gamma cDNA into a nonimmunogenic murine fibrosarcoma: generation of T cells in draining lymph nodes capable of treating established parental metastatic tumor Cancer Immunol Immunother 1993 37: 286–292

Karp SE et al. Cytokine secretion by genetically modified nonimmunogenic murine fibrosarcoma. Tumor inhibition by IL-2 but not tumor necrosis factor J Immunol 1993 150: 896–908

Wexler H . Accurate identification of experimental pulmonary metastases J Nat Cancer Inst 1966 36: 641–645