GLIA
SCOPUS (SonsInc.)SCIE-ISI
0894-1491
1098-1136
Mỹ
Cơ quản chủ quản: John Wiley & Sons Inc. , WILEY
Lĩnh vực:
Cellular and Molecular NeuroscienceNeurology
Các bài báo tiêu biểu
Systemic LPS causes chronic neuroinflammation and progressive neurodegenerationAbstract Inflammation is implicated in the progressive nature of neurodegenerative diseases, such as Parkinson's disease, but the mechanisms are poorly understood. A single systemic lipopolysaccharide (LPS, 5 mg/kg, i.p.) or tumor necrosis factor alpha (TNFα, 0.25 mg/kg, i.p.) injection was administered in adult wild‐type mice and in mice lacking TNFα receptors (TNF... ... hiện toàn bộ
Tập 55 Số 5 - Trang 453-462 - 2007
Microglia as a source and target of cytokinesAbstract Cytokines constitute a significant portion of the immuno‐ and neuromodulatory messengers that can be released by activated microglia. By virtue of potent effects on resident and invading cells, microglial cyto‐ and chemokines regulate innate defense mechanisms, help the initiation and influence the type of immune responses, participate in the recruitment of... ... hiện toàn bộ
Tập 40 Số 2 - Trang 140-155 - 2002
Immune function of astrocytesAbstract Astrocytes are the major glial cell within the central nervous system (CNS) and have a number of important physiological properties related to CNS homeostasis. The aspect of astrocyte biology addressed in this review article is the astrocyte as an immunocompetent cell within the brain. The capacity of astrocytes to express class II major histocompatibility ... ... hiện toàn bộ
Tập 36 Số 2 - Trang 180-190 - 2001
Immune function of microgliaAbstract During the past decade, mechanisms involved in the immune surveillance of the central nervous system (CNS) have moved to the forefront of neuropathological research mainly because of the recognition that most neurological disorders involve activation and, possibly, dysregulation of microglia, the intrinsic macrophages of the CNS. Increasing evidence indicat... ... hiện toàn bộ
Tập 36 Số 2 - Trang 165-179 - 2001
Human cortical glial tumors contain neural stem‐like cells expressing astroglial and neuronal markers in vitroAbstract Neural stem cells from neurogenic regions of mammalian CNS are clonogenic in an in vitro culture system exploiting serum and anchorage withdrawal in medium supplemented with methyl cellulose and the pleiotropic growth factors EGF, FGF2, and insulin. The aim of this study was to test whether cortical glial tumors contain stem‐like cells capable, under this c... ... hiện toàn bộ
Tập 39 Số 3 - Trang 193-206 - 2002
Microglia as neuroprotective, immunocompetent cells of the CNSAbstract The role of glial cells is to support and sustain proper neuronal function and microglia are no exception to this. This viewpoint article emphasizes the fundamental interdependence of microglia and neurons and takes a look at the possibility of what could happen if microglial cells became dysfunctional as a result of aging, genetics, or epigenetics. Could m... ... hiện toàn bộ
Tập 40 Số 2 - Trang 133-139 - 2002
Toll‐like receptor 4 is required for α‐synuclein dependent activation of microglia and astrogliaAbstract Alpha‐synucleinopathies (ASP) are neurodegenerative disorders, characterized by accumulation of misfolded α‐synuclein, selective neuronal loss, and extensive gliosis. It is accepted that microgliosis and astrogliosis contribute to the disease progression in ASP. Toll‐like receptors (TLRs) are expressed on cells of the innate immune system, including glia, a... ... hiện toàn bộ
Tập 61 Số 3 - Trang 349-360 - 2013
Activation of p38 mitogen‐activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injuryAbstract Neuropathic pain is an expression of pathological operation of the nervous system, which commonly results from nerve injury and is characterized by pain hypersensitivity to innocuous stimuli, a phenomenon known as tactile allodynia. The mechanisms by which nerve injury creates tactile allodynia have remained largely unknown. We report that the development o... ... hiện toàn bộ
Tập 45 Số 1 - Trang 89-95 - 2004
Astroglia in CNS injuryAbstract The astroglial response to CNS injury is considered in the context of neuron‐glial relationships. Although previous models suggested that astroglial cells present in “scars” impede axon regrowth owing to irreversible changes in the glial cell following injury, recent in vivo and in vitro studies indicate that astroglial cells exhibit considerable plasticity... ... hiện toàn bộ
Tập 4 Số 2 - Trang 233-243 - 1991
Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's diseaseAbstract Astrocytes are fundamental for brain homeostasis and are at the fulcrum of neurological diseases including Alzheimer's disease (AD). Here, we monitored changes in astroglia morphology throughout the age‐dependent progression of AD. We used an immunohistochemical approach that allows us to determine the domain of glial cytoskeleton, by measuring the surface,... ... hiện toàn bộ
Tập 58 Số 7 - Trang 831-838 - 2010