GLIA
SCOPUS (1988-2025)SCIE-ISI
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Cơ quản chủ quản: John Wiley & Sons Inc. , WILEY
Lĩnh vực:
Cellular and Molecular NeuroscienceNeurology
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
Tập 55 Số 5 - Trang 453-462 - 2007
AbstractInflammation is implicated in the progressive nature of
neurodegenerative diseases, such as Parkinson's disease, but the mechanisms are
poorly understood. A single systemic lipopolysaccharide (LPS, 5 mg/kg, i.p.) or
tumor necrosis factor alpha (TNFα, 0.25 mg/kg, i.p.) injection was administered
in adult wild‐type mice and in mice lacking TNFα receptors (TNF R1/R2−/−) to
discern the mechani...
Microglia as a source and target of cytokines
Tập 40 Số 2 - Trang 140-155 - 2002
AbstractCytokines constitute a significant portion of the immuno‐ and
neuromodulatory messengers that can be released by activated microglia. By
virtue of potent effects on resident and invading cells, microglial cyto‐ and
chemokines regulate innate defense mechanisms, help the initiation and influence
the type of immune responses, participate in the recruitment of leukocytes to
the CNS, and suppo...
Immune function of astrocytes
Tập 36 Số 2 - Trang 180-190 - 2001
AbstractAstrocytes are the major glial cell within the central nervous system
(CNS) and have a number of important physiological properties related to CNS
homeostasis. The aspect of astrocyte biology addressed in this review article is
the astrocyte as an immunocompetent cell within the brain. The capacity of
astrocytes to express class II major histocompatibility complex (MHC) antigens
and costim...
Immune function of microglia
Tập 36 Số 2 - Trang 165-179 - 2001
AbstractDuring the past decade, mechanisms involved in the immune surveillance
of the central nervous system (CNS) have moved to the forefront of
neuropathological research mainly because of the recognition that most
neurological disorders involve activation and, possibly, dysregulation of
microglia, the intrinsic macrophages of the CNS. Increasing evidence indicates
that, in addition to their wel...
Human cortical glial tumors contain neural stem‐like cells expressing astroglial and neuronal markers in vitro
Tập 39 Số 3 - Trang 193-206 - 2002
AbstractNeural stem cells from neurogenic regions of mammalian CNS are
clonogenic in an in vitro culture system exploiting serum and anchorage
withdrawal in medium supplemented with methyl cellulose and the pleiotropic
growth factors EGF, FGF2, and insulin. The aim of this study was to test whether
cortical glial tumors contain stem‐like cells capable, under this culture
system, of forming clones ...
Microglia as neuroprotective, immunocompetent cells of the CNS
Tập 40 Số 2 - Trang 133-139 - 2002
AbstractThe role of glial cells is to support and sustain proper neuronal
function and microglia are no exception to this. This viewpoint article
emphasizes the fundamental interdependence of microglia and neurons and takes a
look at the possibility of what could happen if microglial cells became
dysfunctional as a result of aging, genetics, or epigenetics. Could microglial
senescence be a factor ...
Toll‐like receptor 4 is required for α‐synuclein dependent activation of microglia and astroglia
Tập 61 Số 3 - Trang 349-360 - 2013
AbstractAlpha‐synucleinopathies (ASP) are neurodegenerative disorders,
characterized by accumulation of misfolded α‐synuclein, selective neuronal loss,
and extensive gliosis. It is accepted that microgliosis and astrogliosis
contribute to the disease progression in ASP. Toll‐like receptors (TLRs) are
expressed on cells of the innate immune system, including glia, and TLR4
dysregulation may play a ...
Activation of p38 mitogen‐activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury
Tập 45 Số 1 - Trang 89-95 - 2004
AbstractNeuropathic pain is an expression of pathological operation of the
nervous system, which commonly results from nerve injury and is characterized by
pain hypersensitivity to innocuous stimuli, a phenomenon known as tactile
allodynia. The mechanisms by which nerve injury creates tactile allodynia have
remained largely unknown. We report that the development of tactile allodynia
following ner...
Astroglia in CNS injury
Tập 4 Số 2 - Trang 233-243 - 1991
AbstractThe astroglial response to CNS injury is considered in the context of
neuron‐glial relationships. Although previous models suggested that astroglial
cells present in “scars” impede axon regrowth owing to irreversible changes in
the glial cell following injury, recent in vivo and in vitro studies indicate
that astroglial cells exhibit considerable plasticity, elevating expression of
the gli...
Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease
Tập 58 Số 7 - Trang 831-838 - 2010
AbstractAstrocytes are fundamental for brain homeostasis and are at the fulcrum
of neurological diseases including Alzheimer's disease (AD). Here, we monitored
changes in astroglia morphology throughout the age‐dependent progression of AD.
We used an immunohistochemical approach that allows us to determine the domain
of glial cytoskeleton, by measuring the surface, volume, and the relationship
bet...