GLIA

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
Steroid hormone receptor expression and function in microglia
GLIA - Tập 56 Số 6 - Trang 659-674 - 2008
Amanda Sierra, Andres Gottfried‐Blackmore, Teresa A. Milner, Bruce S. McEwen, Karen Bulloch
AbstractSteroid hormones such as glucocorticoids and estrogens are well‐known regulators of peripheral immune responses and also show anti‐inflammatory properties in the brain. However, the expression of steroid hormone receptors in microglia, the pivotal immune cell that coordinates the brain inflammatory response, is still controversial. Here we use real time RT‐PCR to show that microglia, isola... hiện toàn bộ
Single‐channel characteristics of the large‐conductance anion channel in rat cortical astrocytes in primary culture
GLIA - Tập 9 Số 3 - Trang 227-237 - 1993
Tuula O. Jalonen
AbstractCultured rat cortical astrocytes, in addition to a variety of voltage‐sensitive potassium channels, also express anion channels. However, the behavior and regulation of these anion channels have been far less studied. This paper describes a patch‐clamp study on a voltage‐sensitive 200–300 pS high‐conductance single‐channel anion current, which seems to possess at least five different open ... hiện toàn bộ
Doxycycline restrains glia and confers neuroprotection in a 6‐OHDA Parkinson model
GLIA - Tập 61 Số 7 - Trang 1084-1100 - 2013
Márcio Lazzarini, Sabine Martin, Mišo Mitkovski, Rita Raisman Vozari, Walter Stühmer, Elaine Aparecida Del Bel
Neuron–glia interactions play a key role in maintaining and regulating the central nervous system. Glial cells are implicated in the function of dopamine neurons and regulate their survival and resistance to injury. Parkinson's disease is characterized by the loss of dopamine neurons in the substantia nigra pars compacta, decreased striatal dopamine levels and consequent onset of extrapyramidal mo... hiện toàn bộ
TREM2 is upregulated in amyloid plaque‐associated microglia in aged APP23 transgenic mice
GLIA - Tập 56 Số 13 - Trang 1438-1447 - 2008
Stefanie Frank, Guido J. Burbach, Michael Bonin, Michael Walter, Wolfgang J. Streit, Ingo Bechmann, Thomas Deller
AbstractAlzheimer's disease (AD) is characterized by extracellular deposits of amyloid‐β protein which attract dense clusters of microglial cells. Here, we analyzed amyloid plaque‐associated areas in aged APP23 transgenic mice, an animal model of AD, by combining laser microdissection with microarray analysis and quantitative RT‐PCR (qPCR). By comparing gene expression profiles, we found that 538 ... hiện toàn bộ
STAT1/IRF‐1 signaling pathway mediates the injurious effect of interferon‐gamma on oligodendrocyte progenitor cells
GLIA - Tập 58 Số 2 - Trang 195-208 - 2010
Yan Wang, Zhihua Ren, Tao Duan, Shilpa Tilwalli, Rajendra Goswami, Roumen Balabanov
AbstractInterferon‐gamma (IFN‐γ) is a pleiotropic cytokine that is critically involved in the pathogenesis of inflammatory demyelinating diseases. There is strong evidence that IFN‐γ can function as a distinct and independent injurious factor to oligodendrocyte progenitor cells (OPCs). The intracellular signaling pathways leading to OPC death, however, remain poorly understood. In this study, we e... hiện toàn bộ
Astrocytes, but not olfactory ensheathing cells or Schwann cells, promote myelination of CNS axons in vitro
GLIA - Tập 56 Số 7 - Trang 750-763 - 2008
Annette Sørensen, Keith Moffat, Christine E. Thomson, Susan C. Barnett
AbstractWe have examined the interaction between olfactory ensheathing cells (OECs), Schwann cells (SC), oligodendrocytes, and CNS axons using cultures generated from embryonic rat spinal cord. Oligodendrocyte process extension and myelination in these cultures was poor if the cells were plated on OECs or SCs. Myelin internodes and nodes of Ranvier formed frequently if these cultures were plated o... hiện toàn bộ
Remyelination of cytokine‐ or antibody‐demyelinated CNS aggregate cultures is inhibited by macrophage supplementation
GLIA - Tập 45 Số 3 - Trang 278-286 - 2004
Lara T. Diemel, Guus Wolswijk, Samuel J. Jackson, M L Cuzner
AbstractRemyelination in CNS aggregate cultures is determined both by macrophage enrichment and the mode of demyelination. Despite the same degree of myelin loss, accumulation of MBP in anti‐MOG antibody‐demyelinated aggregates overtakes that of controls, while recovery is significantly delayed following IFN‐γ‐induced demyelination. In antibody‐treated cultures, remyelination was associated with a... hiện toàn bộ
The antiapoptotic effect of guanosine is mediated by the activation of the PI 3‐kinase/AKT/PKB pathway in cultured rat astrocytes
GLIA - Tập 46 Số 4 - Trang 356-368 - 2004
Patrizia Di Iorio, Patrizia Ballerini, U. Traversa, Ferdinando Nicoletti, Iolanda D’Alimonte, Sonya Kleywegt, Eva S. Werstiuk, Michel P. Rathbone, Francesco Caciagli, Renata Ciccarelli
AbstractGuanosine has many trophic effects in the CNS, including the stimulation of neurotrophic factor synthesis and release by astrocytes, which protect neurons against excitotoxic death. Therefore, we questioned whether guanosine protected astrocytes against apoptosis induced by staurosporine. We evaluated apoptosis in cultured rat brain astrocytes, following exposure (3 h) to 100 nM staurospor... hiện toàn bộ
KCa3.1—a microglial target ready for drug repurposing?
GLIA - Tập 64 Số 10 - Trang 1733-1741 - 2016
E Dale, Roland G. W. Staal, Claudia Eder, Thomas Möller
Over the past decade, glial cells have attracted attention for harboring unexploited targets for drug discovery. Several glial targets have attracted de novo drug discovery programs, as highlighted in this GLIA Special Issue. Drug repurposing, which has the objective of utilizing existing drugs as well as abandoned, failed, or not yet pursued clinical development candidates for new indications, mi... hiện toàn bộ
Hormones and diet, but not body weight, control hypothalamic microglial activity
GLIA - Tập 62 Số 1 - Trang 17-25 - 2014
Yuanqing Gao, Nickki Ottaway, Sonja C. Schriever, Beata Legutko, Cristina García‐Cáceres, Esther de la Fuente, Clarita Mergen, Susanne Bour, Joshua P. Thaler, Randy J. Seeley, Jessica A. Filosa, Javier E. Stern, Diego Pérez–Tilve, Michael W. Schwartz, Matthias H. Tschöp, Chun‐Xia Yi
The arcuate nucleus (ARC) of the hypothalamus plays a key role in sensing metabolic feedback and regulating energy homeostasis. Recent studies revealed activation of microglia in mice with high‐fat diet (HFD)‐induced obesity (DIO), suggesting a potential pathophysiological role for inflammatory processes within the hypothalamus. To further investigate the metabolic causes and molecular underpinnin... hiện toàn bộ
Tổng số: 180   
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 10