Frontiers in Molecular Biosciences

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Bioevaluation and Targeted Modification of Temporin-FL From the Skin Secretion of Dark-Spotted Frog (Pelophylax nigromaculatus)
Frontiers in Molecular Biosciences - Tập 8
Wenjie Wang, Wanqing Yang, Shouying Du, Xinping Xi, Chengbang Ma, Lei Wang, Mei Zhou
Bioactive proteins secreted by the granular glands of amphibian skin play a self-defensive role, and exhibit various bioactivities in vitro and in vivo. In light of the severity of the problem of antibiotic resistance for treating infections, many antimicrobial peptides (AMPs) have been developed and applied in clinical microbial treatm...... hiện toàn bộ
Simple Methods and Rational Design for Enhancing Aptamer Sensitivity and Specificity
Frontiers in Molecular Biosciences - Tập 5
Priya Kalra, Abhijeet Dhiman, William C. Cho, John G. Bruno, Tarun Kumar Sharma
Identification of Prognostic Glycolysis-Related lncRNA Signature in Tumor Immune Microenvironment of Hepatocellular Carcinoma
Frontiers in Molecular Biosciences - Tập 8
Yang Bai, Haiping Lin, Jiaqi Chen, Yulian Wu, Shi’an Yu
Purpose: The purpose of this study was to construct a novel risk scoring model with prognostic value that could elucidate tumor immune microenvironment of hepatocellular carcinoma (HCC).Samples and methods: Data were obtained through The Cancer Genome Atlas (TCGA) database. Univariate Cox analysis, least absolute shrinkage and ...... hiện toàn bộ
Non-lysine ubiquitylation: Doing things differently
Frontiers in Molecular Biosciences - Tập 9
Ian R. Kelsall
The post-translational modification of proteins with ubiquitin plays a central role in nearly all aspects of eukaryotic biology. Historically, studies have focused on the conjugation of ubiquitin to lysine residues in substrates, but it is now clear that ubiquitylation can also occur on cysteine, serine, and threonine residues, as well as on the N-terminal amino group of proteins. Paradigm...... hiện toàn bộ
Digital-Droplet PCR for Quantification of CD19-Directed CAR T-Cells
Frontiers in Molecular Biosciences - Tập 7
Thomas Mika, Abdelouahid Maghnouj, Susanne Klein‐Scory, Swetlana Ladigan‐Badura, Alexander Baraniskin, Julia Thomson, Justin Hasenkamp, Stephan A. Hahn, Gerald Wulf, Roland Schroers
Does Early Childhood Vaccination Protect Against COVID-19?
Frontiers in Molecular Biosciences - Tập 7
Karzan R. Sidiq, Dana Khdr Sabir, Shakhawan M. Ali, Rimantas Kodzius
NMR Metabolite Profiles of the Bivalve Mollusc Mytilus galloprovincialis Before and After Immune Stimulation With Vibrio splendidus
Frontiers in Molecular Biosciences - Tập 8
Riccardo Frizzo, Enrico Bortoletto, Tobia Riello, Luigi Leanza, Elisabetta Schievano, Paola Venier, Stefano Mammi
The hemolymph metabolome of Mytilus galloprovincialis injected with live Vibrio splendidus bacteria was analyzed by 1H-NMR spectrometry. Changes in spectral hemolymph profiles were already detected after mussel acclimation (3 days at 18 or 25 °C). A significant decrease of succinic acid was accompanied by an increas...... hiện toàn bộ
Current State of Target Treatment in BRAF Mutated Melanoma
Frontiers in Molecular Biosciences - Tập 7
Enrica T. Tanda, Irene Vanni, Andrea Boutros, Virginia Andreotti, William Bruno, Paola Ghiorzo, Francesco Spagnolo
Players in Mitochondrial Dynamics and Female Reproduction
Frontiers in Molecular Biosciences - Tập 8
Weiwei Zou, Dongmei Ji, Zhiguo Zhang, Li Yang, Yunxia Cao
Mitochondrial dynamics (fission and fusion) are essential physiological processes for mitochondrial metabolic function, mitochondrial redistribution, and mitochondrial quality control. Various proteins are involved in regulating mitochondrial dynamics. Aberrant expression of these proteins interferes with mitochondrial dynamics and induces a range of diseases. Multiple therapeutic approach...... hiện toàn bộ
SARS-CoV-2 Spike Protein Unlikely to Bind to Integrins via the Arg-Gly-Asp (RGD) Motif of the Receptor Binding Domain: Evidence From Structural Analysis and Microscale Accelerated Molecular Dynamics
Frontiers in Molecular Biosciences - Tập 9
Houcemeddine Othman, Haifa Ben Messaoud, Oussema Khamessi, Hazem Ben-Mabrouk, Kaïs Ghedira, Avani Bharuthram, Florette K. Treurnicht, Ikechukwu Achilonu, Yasien Sayed, Najet Srairi‐Abid
The Receptor Binding Domain (RBD) of SARS-CoV-2 virus harbors a sequence of Arg-Gly-Asp tripeptide named RGD motif, which has also been identified in extracellular matrix proteins that bind integrins as well as other disintegrins and viruses. Accordingly, integrins have been proposed as host receptors for SARS-CoV-2. However, given that the microenvironment of the RGD motif imposes a struc...... hiện toàn bộ
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