The Present State and Future Perspectives of Cardiac Regenerative Therapy Using Human Pluripotent Stem CellsFrontiers in Cardiovascular Medicine - Tập 8
Y Soma, Yuika Morita, Yoshikazu Kishino, Hideaki Kanazawa, Keiichi Fukuda, Shugo Tohyama
The number of patients with heart failure (HF) is increasing with aging in our
society worldwide. Patients with HF who are resistant to medication and device
therapy are candidates for heart transplantation (HT). However, the shortage of
donor hearts is a serious issue. As an alternative to HT, cardiac regenerative
therapy using human pluripotent stem cells (hPSCs), such as human embryonic stem
ce... hiện toàn bộ
Case report: Transplantation of human induced pluripotent stem cell-derived cardiomyocyte patches for ischemic cardiomyopathyFrontiers in Cardiovascular Medicine - Tập 9
Shigeru Miyagawa, Satoshi Kainuma, Takuji Kawamura, Kota Suzuki, Yoshito Ito, Hiroko Iseoka, Emiko Ito, Maki Takeda, Masao Sasai, Noriko Mochizuki‐Oda, Tomomi Shimamoto, Yukako Nitta, Hiromi Dohi, Tadashi Watabe, Yasushi Sakata, Köichi Toda, Yoshiki Sawa
Despite major therapeutic advances, heart failure, as a non-communicable
disease, remains a life-threatening disorder, with 26 million patients
worldwide, causing more deaths than cancer. Therefore, novel strategies for the
treatment of heart failure continue to be an important clinical need. Based on
preclinical studies, allogenic human induced pluripotent stem cell-derived
cardiomyocyte (hiPSC-C... hiện toàn bộ
Why Is COVID-19 More Severe in Patients With Diabetes? The Role of Angiotensin-Converting Enzyme 2, Endothelial Dysfunction and the Immunoinflammatory SystemFrontiers in Cardiovascular Medicine - Tập 7
Jacob Roberts, Antonia L. Pritchard, Andrew T. Treweeke, Adriano G. Rossi, Nicole Brace, Paul A. Cahill, Sandra MacRury, Jun Wei, Ian L. Megson
Meta-analyses have indicated that individuals with type 1 or type 2 diabetes are
at increased risk of suffering a severe form of COVID-19 and have a higher
mortality rate than the non-diabetic population. Patients with diabetes have
chronic, low-level systemic inflammation, which results in global cellular
dysfunction underlying the wide variety of symptoms associated with the disease,
including a... hiện toàn bộ
Prognostic Significance of Feature-Tracking Right Ventricular Global Longitudinal Strain in Non-ischemic Dilated CardiomyopathyFrontiers in Cardiovascular Medicine - Tập 8
Marco Cittar, Alberto Cipriani, Marco Merlo, Giancarlo Vitrella, Marco Masè, Anna Carrer, Giulia Barbati, Manuel Belgrano, Lorenzo Pagnan, Manuel De Lazzari, Benedetta Giorgi, Maria Assunta Cova, Sabino Iliceto, Cristina Basso, Davide Stolfo, Gianfranco Sinagra, Martina Perazzolo Marra
Aims: Left ventricular global longitudinal strain (GLS) by cardiac magnetic
resonance feature tracking (CMR-FT) analysis has shown an incremental prognostic
value compared to classical parameters in non-ischemic dilated cardiomyopathy
(NICM). However, less is known about the role of right ventricular (RV) GLS. Our
objective was to evaluate the prognostic impact of RV-GLS by CMR-FT analysis in
a po... hiện toàn bộ
Heart Failure Probability and Early Outcomes of Critically Ill Patients With COVID-19: A Prospective, Multicenter StudyFrontiers in Cardiovascular Medicine - Tập 8
Weibo Gao, Jiasai Fan, Di Sun, Mengxi Yang, Wei Guo, Liyuan Tao, Jingang Zheng, Jihong Zhu, Tianbing Wang, Jingyi Ren
Background: The relationship between cardiac functions and the fatal outcome of
coronavirus disease 2019 (COVID-19) is still largely underestimated. We aim to
explore the role of heart failure (HF) and NT-proBNP in the prognosis of
critically ill patients with COVID-19 and construct an easy-to-use predictive
model using machine learning.Methods: In this multicenter and prospective study,
a total o... hiện toàn bộ