Fühner-Wieland's Sammlung von Vergiftungsfällen

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Genetic and epigenetic cancer chemoprevention on molecular targets during multistage carcinogenesis
Fühner-Wieland's Sammlung von Vergiftungsfällen - Tập 90 - Trang 2389-2404 - 2016
Hyung Sik Kim, Sam Kacew, Byung Mu Lee
The main goal of cancer chemoprevention is to prevent or halt the progression of carcinogenesis with the administration of synthetic or natural compounds. Fundamental chemopreventive strategies include inhibition of genetic damage, anti-proliferation/cell cycle regulation, and induction of apoptosis and anti-inflammatory processes, which may be critical for carcinogenesis intervention. Recently, a...... hiện toàn bộ
Toxicological assessment of magnesium oxide nanoparticles in HT29 intestinal cells
Fühner-Wieland's Sammlung von Vergiftungsfällen - Tập 93 - Trang 1491-1500 - 2019
Anna Mittag, Thomas Schneider, Martin Westermann, Michael Glei
Nanoparticles (NPs) are increasingly used in different consumer-related areas, for instance in food packaging or as additives, because of their enormous potential. Magnesium oxide (MgO) is an EU-approved food additive (E number 530). It is commonly used as a drying agent for powdered foods, for colour retention or as a food supplement. There are no consistent results regarding the effects of oral ...... hiện toàn bộ
Aristolochic acid IVa forms DNA adducts in vitro but is non-genotoxic in vivo
Fühner-Wieland's Sammlung von Vergiftungsfällen - Tập 95 - Trang 2839-2850 - 2021
Jingjing Wan, Ruixue Chen, Zhou Yang, Jing Xi, Yiyi Cao, Yu Chen, Xinyu Zhang, Yang Luan
Aristolochic acids (AAs) are a family of natural compounds with AA I and AA II being known carcinogens, whose bioactivation causes DNA adducts formation. However, other congeners have rarely been investigated. This study aimed to investigate genotoxicity of AA IVa, which differs from AA I by a hydroxyl group, abundant in Aristolochiaceae plants. AA IVa reacted with 2'-deoxyadenosine (dA) and 2'-de...... hiện toàn bộ
Reactivators of organophosphate-inhibited cholinesterase
Fühner-Wieland's Sammlung von Vergiftungsfällen - Tập 49 - Trang 285-291 - 1982
Vjera Deljac, Matej Maksimović, Ljiljana Radović, Dušanka Rakin, Verica Markov, Ivo Bregovec, Zlatko Binenfeld
Eleven isomeric phenylhydroxymethyl and cyclohexylhydroxymethyl derivatives of 1-(2-hydroxyiminomethyl-1-pyridinio)-3-(1-pyridinio)-2-oxapropane diiodide and 1-(4-hydroxyiminomethyl-1-pyridinio)-3-(1-pyridinio)-2-oxapropane diiodide were prepared and characterized by spectroscopic methods and pKa values. The inhibitory power (I50) of the investigated oximes was determined on purified bovine erythr...... hiện toàn bộ
Phanodorm-Vergiftung mit ungewöhnlichem Dekubitus (Suicid.)
Fühner-Wieland's Sammlung von Vergiftungsfällen - Tập 10 Số 1 - Trang A81-A82 - 1939
O. Scheurer
Evaluation of a testicular sperm head counting technique using rats exposed to dimethoxyethyl phthalate (DMEP), glycerolα-monochlorohydrin (GMCH), epichlorohydrin (ECH), formaldehyde (FA), or methyl methanesulphonate (MMS)
Fühner-Wieland's Sammlung von Vergiftungsfällen - Tập 53 - Trang 71-78 - 1983
S. L. Cassidy, K. M. Dix, T. Jenkins
Single dosages of DMEP (1,000–2,000 mg/kg), GMCH (50 mg/kg), ECH (25 and 50 mg/kg), FA (100 and 200 mg/kg), and MMS (100–400 mg/kg) were administered orally to 10 week old male Wistar rats. The rats were necropsied on the 11th day following dosing. The testes were weighed, homogenised and sonicated; numbers of sperm heads (total and abnormal) were counted and percentage sperm head abnormalities we...... hiện toàn bộ
The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines
Fühner-Wieland's Sammlung von Vergiftungsfällen - Tập 92 - Trang 2649-2664 - 2018
Fiona R. Kolbinger, Emily Koeneke, Johannes Ridinger, Tino Heimburg, Michael Müller, Theresa Bayer, Wolfgang Sippl, Manfred Jung, Nikolas Gunkel, Aubry K. Miller, Frank Westermann, Olaf Witt, Ina Oehme
High histone deacetylase (HDAC) 8 and HDAC10 expression levels have been identified as predictors of exceptionally poor outcomes in neuroblastoma, the most common extracranial solid tumor in childhood. HDAC8 inhibition synergizes with retinoic acid treatment to induce neuroblast maturation in vitro and to inhibit neuroblastoma xenograft growth in vivo. HDAC10 inhibition increases intracellular acc...... hiện toàn bộ
Beobachtungen bei einer Wasserglas-Vergiftung
Fühner-Wieland's Sammlung von Vergiftungsfällen - Tập 10 - Trang A139-A140 - 1939
Felix Steigerwaldt
Über die toxische Beständigkeit arsenhaltiger Reizkampfstoffe
Fühner-Wieland's Sammlung von Vergiftungsfällen - Tập 17 - Trang 210-213 - 1958
J. Martinius
Die arsenhaltigen Blaukreuzkampfstoffe des letzten Weltkrieges werden im allgemeinen leicht durch Wasser zersetzt und können deshalb durch Versenken ins Meer unschädlich gemacht werden. Praktisch so gut wie beständig im Meerwasser ist allein der BlaukreuzkampfstoffAdamsit. Es wird über einen Fund dieses Kampfstoffes in der Ostsee berichtet. Das aufgefischte Adamsit war trotz jahrelanger Einwirkung...... hiện toàn bộ
Cytotoxic effects of hexavalent chromium in cultured murine macrophages
Fühner-Wieland's Sammlung von Vergiftungsfällen - Tập 66 - Trang 347-353 - 1992
Margot Martiny Christensen, Erik Ernst, Svend Ellermann-Eriksen
The in vitro effect of hexavalent chromium (CrVI) on mouse peritoneal macrophages was investigated. Our results demonstrate the existence of a threshold concentration of 2.5 ΜM of CrVI above which chromium affects the viability of macrophages in a concentration dependent manner. Morphological changes were seen with increasing concentrations of chromium. Evidence is presented that protein productio...... hiện toàn bộ
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