Renal effects of in utero exposure to mercuric chloride in rats
Tóm tắt
The transplacental nephrotoxicity of mercuric chloride has been studied in female Sprague-Dawley rats. Mercuric chloride was injected s. c. to rats at the dose of 1 mg/kg during the last 8 gestational days or the whole pregnancy. Both mothers and newborns developed a transient renal dysfunction resulting in an increased urinary excretion of beta2-microglobulin and albumin. In mothers and their female offspring, these effects were completely reversible and did not influence the subsequent evolution of the renal function. In the male offspring, however, transitory changes in protein excretion were again observed a few months later, concomitantly with an enhanced accumulation of alpha2u-globulin in the kidney. The transfer of mercury from maternal to fetal tissues was very small. The kidney concentrations of mercury in newborns were more than 300 times lower than in mothers. The barrier role of the placenta is not sufficient to prevent the occurrence of renal effects in the offspring of rats treated with inorganic mercury during pregnancy.
Tài liệu tham khảo
Bakka A, Samarawekrama GP, Webb M (1981) Metabolism of zinc and copper in the neonate: effect of cadmium administration during late gestation in the rat on the zinc and copper metabolism of the newborn. Chem Biol Interact 34: 161–171
Bernard AM, Lauwerys RR (1983) Continuous flow system for the automation of latex immunoassay by particle counting. Clin Chem 29: 1007–1011
Bernard AM, Lauwerys RR (1991) Proteinuria: changes and mechanisms in toxic nephropathies. Crit Rev Toxicol 21: 373–405
Coyle P, Hartley T (1981) Automated determination of mercury in urine and blood by the Magos reagent and cold vapour atomic absorption spectrometry. Anal Chem 53: 354–356
Falconer-Smith JF, Van Hegan RI, Esmouff MP, Ross BP (1979) Characteristics of renal handling of human immunoglobulin light chain by the perfused rat kidney. Clin Sci 57: 113–120
Gale T, Ferm V (1971) Embryopathic effects of mercuric salts. Life Sci 10: 1341–1347
Kavlock RJ, Gray LE (1983) Postnatal evaluation of morphological and functional effects of prenatal exposure to nitrofen in the Long-Evans rat. J Toxicol Environ Health 11: 679–690
Kavlock RJ, Rogers EH, Rehnberg BF (1986) Renal functional teratogenesis resulting from adriamycin exposure. Teratology 33: 213–220
Koos BJ, Longo LD (1976) Mercury toxicity in the pregnant woman, fetus, and newborn infant. Am J Obstet Gynecol 126: 390–409
Lauwerys RR, Bonnier Ch, Evrard Ph, Gennart JPh, Bernard A (1987) Prenatal and early postnatal intoxication by inorganic mercury resulting from the maternal use of mercury containing soap. Hum Toxicol 6: 253–256
Mallié JP, Gerard H, Gerard A (1986) In utero gentamicin induced nephrotoxicity in rats. Pediatr Pharmacol 5: 229–239
Olson MJ, Johnson JT, Reidy CA (1990) A comparison of male rat and human urinary proteins. Implications for human resistance to hyaline droplet nephropathy. Toxicol Appl Pharmacol 102: 524–536
Provoost AP, De Keyzer MH, Wolff ED and Molenaar JC (1977) Development of renal function in the rat. The measurement of GFR and ERPF and correlation to body and kidney weight. Renal Physiol 6: 1–9
Saillenfait AM, Brondeau MT, Zissu D, De Ceauritz J (1989) Effects of prenatal methylmercury exposure on urinary proximal tubular enzyme excretion in neonatal rats. Toxicology 55: 153–160
Saillenfait AM, Payan JP, Brondeau MT, Zissu D, De Ceauritz J (1991) Changes in urinary proximal tubule parameters in neonatal rats exposed to cadmium chloride during pregnancy. J Appl Toxicol 11: 23–27
Viau C, Bernard A, Lauwerys R (1986) Determination of rat beta2-microglobulin in urine and serum. I. Development of an immunoassay based on latex particle agglutination. J Appl Toxicol 6: 185–189
Webb M (1979) The metallothioneins In: Webb M (ed). The chemistry, biochemistry and biology of cadmium. Topics in environmental health. Elsevier/North-Holland Biomedical Press, Amsterdam, pp 195–266