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Fühner-Wieland's Sammlung von Vergiftungsfällen

  1432-0738

  0370-8497

 

Cơ quản chủ quản:  Springer Heidelberg , Springer Verlag

Lĩnh vực:
Medicine (miscellaneous)ToxicologyHealth, Toxicology and Mutagenesis

Các bài báo tiêu biểu

Determination of chinoform in biological fluids and nervous tissues of the dog by gas chromatography-mass spectrometry
Tập 59 - Trang 374-378 - 1987
Yasuhiko Matsuki, Tomiharu Ito, Katsuharu Fukuhara, Masahiro Abe, Tsuneo Othaki, Toshio Nambara
A sensitive gas chromatographic-mass spectrometric method for the determination of 5-chloro-7-iodo-8-hydroxyquinoline (chinoform, clioquinol) in biological fluids and nervous tissues is described. Chinoform was converted into the pentafluorobenzyl ether, which was separated on a 10% Dexsil 300GC column and determined by the use of chinoform-d 4 as an internal standard. The clean-up of chionoform in plasma and urine was efficiently achieved by extracting with benzene, while the drug in the tissue was pretreated successively by extraction with 12.5% v/v pyridine-benzene, separation on a Clin-Elut cartridge and adsorption on alumina. The quantitation limit of chinoform was 100pg, and the recovery rates of chinoform added to plasma and tissue were 98% and 92%, respectively. The chinoform levels in biological fluids and tissues in dogs after prolonged administration of the drug at a dose of 400 mg/kg/day were measured by the proposed method. The plasma level and tissue distribution of chinoform are also discussed.
Acute and subchronic toxicity of sulfotep
Tập 33 Số 1 - Trang 1-16 - 1974
Georg Kimmerle, O. R. Klimmer
Vergiftungen durch Schädlingsbekämpfungsmittel
Tập 11 - Trang C103-C124 - 1940
Hans Joachim Kießig
Adverse outcome pathways
Tập 91 - Trang 4023-4024 - 2017
Hermann M. Bolt
Evaluation of the use of salivary lead levels as a surrogate of blood lead or plasma lead levels in lead exposed subjects
Tập 80 Số 10 - Trang 633-637 - 2006
Fernando Barbosa, Maria Heloísa Corrêa Rodrigues, Maria R. Buzalaf, Francisco José Krug, Raquel Fernanda Gerlach, José Eduardo Tanus‐Santos
Adverse outcome pathways: opportunities, limitations and open questions
Tập 91 Số 11 - Trang 3477-3505 - 2017
Marcel Leist, Ahmed Ghallab, Rabea Graepel, Rosemarie Marchan, Reham Hassan, Susanne Hougaard Bennekou, Alice Limonciel, Mathieu Vinken, Stefan Schildknecht, Tanja Waldmann, Erik H.J. Danen, B. van Ravenzwaay, Hennicke Kamp, Iain Gardner, Patrício Godoy, Frédéric Bois, Albert Braeuning, Raymond Reif, Franz Oesch, Dirk Drasdo, Stefan Höhme, Michael Schwarz, Thomas Hartung, Thomas Braunbeck, Joost B. Beltman, Harry Vrieling, Ferrán Sanz, Anna Forsby, Domenico Gadaleta, Ciarán Fisher, Jens M. Kelm, David A. Fluri, Gerhard Ecker, Barbara Zdrazil, Andrea Terron, Paul Jennings, Bart van der Burg, Steven Dooley, Annemarie H. Meijer, Egon Willighagen, Marvin Martens, Chris T. Evelo, Enrico Mombelli, Olivier Taboureau, Alberto Mantovani, Barry Hardy, Bjørn E. V. Koch, Sylvia Escher, Christoph van Thriel, Cristina Cadenas, Dinant Kroese, Bob van de Water, Jan G. Hengstler
Alterations in neurofilaments content and calpains activity of sciatic nerve of carbon disulfide-treated rats
Tập 83 - Trang 587-594 - 2009
Fuyong Song, Cuili Zhang, Qingshan Wang, Tao Zeng, Keqin Xie
Chronic exposure to carbon disulfide (CS2) can induce polyneuropathy in occupational worker and experimental animals, but underlying mechanism for CS2 neurotoxicity is currently unknown. In the present study, male Wistar rats were randomly divided into two experimental groups and one control group. The rats in two experimental groups were treated with CS2 by gavage at dosages of 300 and 500 mg/kg per day, respectively, five times per week for 12 weeks. The contents of neurofilament triplet proteins (NF-H, NF-M, NF-L) and two calpain isoforms (m-calpain and u-calpain) in sciatic nerves were determined by immunoblotting. In the meantime, the mRNA levels of NF-H, NF-M and NF-L in spinal cords were quantified by reverse transcriptase-polymerase chain reaction, and the total activity of calpains in sciatic nerves was measured by fluorescence assay. Results showed that the contents of NF-M and NF-L in CS2-treated rats sciatic nerves increased significantly except NF-M in low dose group. The contents and activity of m-calpain and u-calpain in sciatic nerve also demonstrated a significant elevation. Furthermore, the levels of mRNA expression of NFH, NFM and NFL genes were up-regulated consistently in spinal cords of treated rats. These findings suggested that CS2 intoxication was associated with the disruption of neurofilaments homeostasis and activiation of calpains in rat sciatic nerves, which might be involved in the development of CS2-induced peripheral neuropathy.
Toxische Erscheinungen bei der Goldtherapie
Tập 8 Số 1 - Trang A49-A50 - 1937
G. J. Villiers Crosby, Hubert Vollmer
Absorption of blue light by cigarette smoke components is highly toxic for retinal pigmented epithelial cells
Tập 93 - Trang 453-465 - 2018
Corinne Zinflou, Patrick J. Rochette
Lesion to the retinal pigment epithelium (RPE) is a crucial event in the development of age-related macular degeneration (AMD), the leading cause of blindness in industrialized countries. Tobacco smoking and high-energy visible blue (HEV; 400–500 nm) light exposure are major environmental risk factors for AMD. Individually, they have been shown to cause damage to the RPE. Tobacco smoke contains toxic polycyclic aromatic hydrocarbons (PAH) that can accumulate in RPE and which absorb HEV light. It can thus be postulated that the interaction between both factors in RPE cells can have a synergic toxic effect to the RPE. To test this hypothesis, cultured human RPE cells (ARPE19) were treated with nanomolar concentrations of benzo[a]pyrene (BaP) or indeno[1,2,3-cd]pyrene (IcdP), then exposed to HEV light using an irradiation system that mimics the solar spectrum normally transmitted to the retina through the human ocular media. Using mitochondrial network morphology changes and key features of AMD-related RPE defects such as apoptotic cell death and oxidative stress, we demonstrate that a synergistic phototoxicity is generated when nanomolar concentrations (≤ 500 nM) of IcdP interact with sub-lethal amounts of HEV light. Indeed, we found IcdP to be at least 3000 times more toxic for RPE cells when irradiated with HEV light. This synergy translates into disruption of mitochondrial network, ROS enhanced accumulation and apoptosis of RPE cells. Our results underline an important interplay between two environmental risk factors involved in AMD progression and strongly indicate that IcdP, upon interaction with HEV light, may initiate the biological mechanisms underlying the association between cigarette smoking and AMD-related RPE degeneration.
Hibiscus protocatechuic acid inhibits lipopolysaccharide-induced rat hepatic damage
Tập 77 Số 1 - Trang 42-47 - 2003
Lin Lin, Hsieh Y.-J., Chou F.-P., Wang C.-J., Cheng M.-T., Tseng T.-H.