Bi-directional changes in the levels of messenger RNAs encoding γ-aminobutyric acidA receptor α subunits after flurazepam treatmentEuropean Journal of Pharmacology: Molecular Pharmacology - Tập 226 - Trang 335 - 1992
O'Donovan Michael C., McGuffin Peter, Buckland Paul R., Spurlock Gillian
Changes in γ-aminobutyric acidA (GABAA) receptor function have been observed following chronic benzodiazepine administration. The molecular mechanisms responsible are unknown, but one possibility is that benzodiazepines induce alterations in the expression of genes which encode subunits of the GABAA receptor complex, resulting in changes in the receptor structure and function. We have investigated...... hiện toàn bộ
#Benzodiazepines #Tolerance #GABAA receptor #mRNA levels #(Rat)