EPMA Journal

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Antithrombotic and antiplatelet effects of plant-derived compounds: a great utility potential for primary, secondary, and tertiary care in the framework of 3P medicine
EPMA Journal - Tập 13 - Trang 407-431 - 2022
Peter Kubatka, Alena Mazurakova, Lenka Koklesova, Marek Samec, Juraj Sokol, Samson Mathews Samuel, Erik Kudela, Kamil Biringer, Ondrej Bugos, Martin Pec, Barbara Link, Marian Adamkov, Karel Smejkal, Dietrich Büsselberg, Olga Golubnitschaja
Thromboembolism is the third leading vascular disease, with a high annual incidence of 1 to 2 cases per 1000 individuals within the general population. The broader term venous thromboembolism generally refers to deep vein thrombosis, pulmonary embolism, and/or a combination of both. Therefore, thromboembolism can affect both – the central and peripheral veins. Arterial thromboembolism causes syste... hiện toàn bộ
Chronic inflammation: key player and biomarker-set to predict and prevent cancer development and progression based on individualized patient profiles
EPMA Journal - Tập 10 - Trang 365-381 - 2019
Shehua Qian, Olga Golubnitschaja, Xianquan Zhan
A strong relationship exists between tumor and inflammation, which is the hot point in cancer research. Inflammation can promote the occurrence and development of cancer by promoting blood vessel growth, cancer cell proliferation, and tumor invasiveness, negatively regulating immune response, and changing the efficacy of certain anti-tumor drugs. It has been demonstrated that there are a large num... hiện toàn bộ
Muti-omics integration analysis revealed molecular network alterations in human nonfunctional pituitary neuroendocrine tumors in the framework of 3P medicine
EPMA Journal - Tập 13 - Trang 9-37 - 2022
Siqi Wen, Chunling Li, Xianquan Zhan
Nonfuctional pituitary neuroendocrine tumor (NF-PitNET) is highly heterogeneous and generally considered a common intracranial tumor. A series of molecules are involved in NF-PitNET pathogenesis that alter in multiple levels of genome, transcriptome, proteome, and metabolome, and those molecules mutually interact to form dynamically associated molecular-network systems. This article reviewed signa... hiện toàn bộ
Mutual effect of homocysteine and uric acid on arterial stiffness and cardiovascular risk in the context of predictive, preventive, and personalized medicine
EPMA Journal - Tập 13 - Trang 581-595 - 2022
Zhiyuan Wu, Haiping Zhang, Zhiwei Li, Haibin Li, Xinlei Miao, Huiying Pan, Jinqi Wang, Xiangtong Liu, Xiaoping Kang, Xia Li, Lixin Tao, Xiuhua Guo
Arterial stiffness is a major risk factor and effective predictor of cardiovascular diseases and a common pathway of pathological vascular impairments. Homocysteine (Hcy) and uric acid (UA) own the shared metabolic pathways to affect vascular function. Serum uric acid (UA) has a great impact on arterial stiffness and cardiovascular risk, while the mutual effect with Hcy remains unknown yet. This s... hiện toàn bộ
Challenges in breast cancer management and prevention
EPMA Journal - Tập 5 - Trang 1-2 - 2014
Manuel Debald, Walther Kuhn, Olga Golubnitschaja
Automated detection of nine infantile fundus diseases and conditions in retinal images using a deep learning system
EPMA Journal - - Trang 1-13 - 2024
Yaling Liu, Hai Xie, Xinyu Zhao, Jiannan Tang, Zhen Yu, Zhenquan Wu, Ruyin Tian, Yi Chen, Miaohong Chen, Dimitrios P. Ntentakis, Yueshanyi Du, Tingyi Chen, Yarou Hu, Sifan Zhang, Baiying Lei, Guoming Zhang
We developed an Infant Retinal Intelligent Diagnosis System (IRIDS), an automated system to aid early diagnosis and monitoring of infantile fundus diseases and health conditions to satisfy urgent needs of ophthalmologists. We developed IRIDS by combining convolutional neural networks and transformer structures, using a dataset of 7697 retinal images (1089 infants) from four hospitals. It identifie... hiện toàn bộ
Comparative cerebrospinal fluid metabolites profiling in glioma patients to predict malignant transformation and leptomeningeal metastasis with a potential for preventive personalized medicine
EPMA Journal - Tập 11 - Trang 469-484 - 2020
Ji Hye Im, Byong Chul Yoo, Jun Hwa Lee, Kyung-Hee Kim, Tae Hoon Kim, Kyue-Yim Lee, Jong Heon Kim, Jong Bae Park, Ji-Woong Kwon, Sang Hoon Shin, Heon Yoo, Ho-Shin Gwak
Glioma shows progression presenting as malignant transformation or leptomeningeal metastasis (LM). However, longitudinal biopsy of brain parenchyma is difficult due to its critical location, whereas cerebrospinal fluid (CSF) can be obtained serially with a little invasiveness of puncture. Thus, if we could find a biomarker for glioma progression, we could predict such event and determine therapeut... hiện toàn bộ
Frailty mediating the causality between leucocyte telomere length and mortality: a cohort study of 440,551 UK Biobank participants
EPMA Journal - - Trang 1-12
Jian, Xuening, Sun, Wenxin, Zhang, Jie, Zhang, Qiaoyun, Meng, Xiaoni, Lu, Huimin, Zheng, Deqiang, Wu, Lijuan, Wang, Youxin
Previous studies reported leucocyte telomere length (LTL) and frailty were associated with mortality, but it remains unclear whether frailty serves as a mediator in the relationship between leucocyte telomere length and mortality risk. This study aimed to evaluate how measuring LTL and frailty can support early monitoring and prevention of risk of mortality from the prospective of predictive, prev... hiện toàn bộ
Vaccination and autoimmune diseases: is prevention of adverse health effects on the horizon?
EPMA Journal - Tập 8 Số 3 - Trang 295-311 - 2017
Vadalà, Maria, Poddighe, Dimitri, Laurino, Carmen, Palmieri, Beniamino
Autoimmune diseases, including multiple sclerosis and type 1 diabetes mellitus, affect about 5% of the worldwide population. In the last decade, reports have accumulated on various autoimmune disorders, such as idiopathic thrombocytopenia purpura, myopericarditis, primary ovarian failure, and systemic lupus erythematosus (SLE), following vaccination. In this review, we discuss the possible underly... hiện toàn bộ
The review of innovative integration of Kampo medicine and Western medicine as personalized medicine at the first multidisciplinary pain center in Japan
EPMA Journal - Tập 5 - Trang 1-6 - 2014
Young-Chang P Arai, Hiromichi Yasui, Hideya Isai, Takashi Kawai, Makoto Nishihara, Jun Sato, Tatsunori Ikemoto, Sinsuke Inoue, Takahiro Ushida
The Japanese medical system is unique because it is the only country in the world where Western medicine and traditional Japanese medicine including Kampo medicine, traditional Japanese herbal medicine, are used in our daily clinical practice. Pain is essentially an interactive psychophysiological behavior pattern. Thus, an interdisciplinary approach is often recommended in providing appropriate t... hiện toàn bộ
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