The review of innovative integration of Kampo medicine and Western medicine as personalized medicine at the first multidisciplinary pain center in Japan
Tóm tắt
The Japanese medical system is unique because it is the only country in the world where Western medicine and traditional Japanese medicine including Kampo medicine, traditional Japanese herbal medicine, are used in our daily clinical practice. Pain is essentially an interactive psychophysiological behavior pattern. Thus, an interdisciplinary approach is often recommended in providing appropriate therapeutic care for the patients suffering from chronic and intractable pain. In addition, we have been prescribing Kampo medicines in combination with Western medicines as personalized medicine in order to treat patients with chronic pain at our pain center. The aim of our study was to conduct a survey on the current use and the effect of Kampo medicines in our multidisciplinary pain center. Retrospective analysis was performed on 221 out of 487 patients suffering from chronic pain. The most frequent medical complaints for which Kampo medicines were prescribed were lower back/lower limb pain, neck/upper limb pain, various facial pains, headache/migraine, whiplash-associated disorder, and frozen shoulder. Kampo medicines were prescribed based on patient-centered Kampo diagnosis. Moreover, several Kampo medicines generally for the management of psychological symptoms were prescribed for about 70% of the patients. Pain improvement in the patients was categorized as follows: 26.3% with marked improvement, 12.7% with moderate improvement, 38.9% with some improvement, and 19.9% with no improvement. Two thirds of the chronic pain patients with the use of Kampo medicines combined with Western medicine experienced further pain improvements.
Tài liệu tham khảo
Hottenbacher L, Weißhuhn TE, Watanabe K, Seki T, Ostermann J, Witt CM: Opinions on Kampo and reasons for using it–results from a cross-sectional survey in three Japanese clinics. BMC Complement Altern Med. 2013, 13: 108-doi:10.1186/1472-6882-13-108
Moschik EC, Mercado C, Yoshino T, Matsuura K, Watanabe K: Usage and attitudes of physicians in Japan concerning traditional Japanese medicine (kampo medicine): a descriptive evaluation of a representative questionnaire-based survey. Evid Based Complement Alternat Med. 2012, 2012: 139818-doi:10.1155/2012/139818
Arai YC, Nishihara M, Inoue S, Makino I: Kampo diagnostic procedure, Fuku shin, could be a useful diagnostic tool for psychopathological patients suffering from chronic pain. Evid Based Complement Alternat Med. 2013, 2013: 816216-doi:10.1155/2013/816216
Yamakawa J, Motoo Y, Moriya J, Ogawa M, Uenishi H, Akazawa S, Sasagawa T, Nishio M, Kobayashi J: Significance of Kampo, traditional Japanese medicine, in supportive care of cancer patients. Evid Based Complement Alternat Med. 2013, 2013: 746486-doi:10.1155/2013/746486
Pergolizzi J, Ahlbeck K, Aldington D, Alon E, Coluzzi F, Dahan A, Huygen F, Kocot-Kępska M, Mangas AC, Mavrocordatos P, Morlion B, Müller-Schwefe G, Nicolaou A, Pérez Hernández C, Sichère P, Schäfer M, Varrassi G: The development of chronic pain: physiological CHANGE necessitates a multidisciplinary approach to treatment. Curr Med Res Opin. 2013, 29: 1127-1135. doi:10.1185/03007995.2013.810615
Hijikata Y, Miyamae Y, Takatsu H, Sentoh S: Two kampo medicines, jidabokuippo and hachimijiogan alleviate sprains, bruises and arthritis. Evid Based Complement Alternat Med. 2007, 4: 463-467. doi:10.1093/ecam/nel105
Kogure T, Tatsumi T, Shigeta T, Fujinaga H, Sato T, Niizawa A: Effect of kampo medicine on pain and range of motion of osteoarthritis of the hip accompanied by acetabular dysplasia: case report and literature review. Integr Med Insights. 2011, 6: 13-17. doi:10.4137/IMI.S7884
Otsuka K: KAMPO-A Clinical Guide to Theory and Practice. 2010, Edinburgh: Churchill Livingstone, Elsevier
Shibata Y, Wu J: KAMPO Treatment for Climacteric Disorders. 1997, Brookline: Massachusetts, Paradigm Publications
Suzuki Y, Goto K, Ishige A, Komatsu Y, Kamei J: Antinociceptive effect of Gosha-jinki-gan, a Kampo medicine, in streptozotocin-induced diabetic mice. Jpn J Pharmacol. 1999, 79: 169-175.
Omiya Y, Suzuki Y, Yuzurihara M, Murata M, Aburada M, Kase Y, Takeda S: Antinociceptive effect of shakuyakukanzoto, a Kampo medicine, in diabetic mice. J Pharmacol Sci. 2005, 99: 373-380.
Yamaguchi T, Tsujimatsu A, Kumamoto H, Izumi T, Ohmura Y, Yoshida T, Yoshioka M: Anxiolytic effects of yokukansan, a traditional Japanese medicine, via serotonin 5-HT1A receptors on anxiety-related behaviors in rats experienced aversive stress. J Ethnopharmacol. 2012, 143: 533-539. doi:10.1016/j.jep.2012.07.007
Hidaka T, Yonezawa R, Saito S: Kami-shoyo-san, Kampo (Japanese traditional medicine), is effective for climacteric syndrome, especially in hormone-replacement-therapy-resistant patients who strongly complain of psychological symptoms. J Obstet Gynaecol Res. 2013, 39: 223-228. doi:10.1111/j.1447-0756.2012.01936.x
Ogawa K, Kojima T, Matsumoto C, Kamegai S, Oyama T, Shibagaki Y, Muramoto H, Kawasaki T, Fujinaga H, Takahashi K, Hikiami H, Goto H, Kiga C, Koizumi K, Sakurai H, Shimada Y, Yamamoto M, Terasawa K, Takeda S, Saiki I: Identification of a predictive biomarker for the beneficial effect of a Kampo (Japanese traditional) medicine keishibukuryogan in rheumatoid arthritis patients. Clin Biochem. 2007, 40: 1113-1121.
Odaguchi H, Wakasugi A, Ito H, Shoda H, Gono Y, Sakai F, Hanawa T: The efficacy of goshuyuto, a typical Kampo (Japanese herbal medicine) formula, in preventing episodes of headache. Curr Med Res Opin. 2006, 22: 1587-1597.
Ito N, Yabe T, Nagai T, Oikawa T, Yamada H, Hanawa T: A possible mechanism underlying an antidepressive-like effect of Kososan, a Kampo medicine, via the hypothalamic orexinergic system in the stress-induced depression-like model mice. Biol Pharm Bull. 2009, 32: 1716-1722.
Toriizuka K, Kamiki H, Ohmura NY, Fujii M, Hori Y, Fukumura M, Hirai Y, Isoda S, Nemoto Y, Ida Y: Anxiolytic effect of Gardeniae Fructus-extract containing active ingredient from Kamishoyosan (KSS), a Japanese traditional Kampo medicine. Life Sci. 2005, 77: 3010-3020.