Drug Research

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Determination of Mizoribine in Human Plasma Using High-performance Liquid Chromatography: Application to a Pharmacokinetic Study in Chinese Renal Transplant Recipients
Drug Research - Tập 63 Số 07 - Trang 376-381
Bin Ren, Xiaohua Fu, Zhen Zhang, Luoxiu Huang, C. Wang, X. Chen
Strategies in Development and Delivery of Nanotechnology Based Cosmetic Products
Drug Research - Tập 68 Số 10 - Trang 545-552 - 2018
Usama Ahmad, Zeeshan Ahmad, Ahmed Shehab Khan, Juber Akhtar, Satya P. Singh, Farhan Jalees Ahmad
AbstractThe science of formulation involving cosmetic ingredients has always been a challenge since the release of active components greatly depends upon the carrier system involved and the selectivity of skin barrier. The principle obstacle of the skin resides in the epidermis and it’s hard for many active components to cross it. The formulation related factors like size of particles, viscosity a... hiện toàn bộ
Development of Multiple-Unit Floating Drug Delivery System of Clarithromycin: Formulation, in vitro Dissolution by Modified Dissolution Apparatus, in vivo Radiographic Studies in Human Volunteers
Drug Research - Tập 67 Số 07 - Trang 412-418 - 2017
Arun Reddy, Narendar Reddy
AbstractClarithromycin (CM), a broad spectrum macrolide antibiotic used to eradicate H. pylori in peptic ulcer. Clarithromycin (CM) is well absorbed from the gastrointestinal tract, but has a bioavailability of 50% due to rapid biodegradation. The aim of this investigation was to increase the gastric residence time, and to control the drug release of clarithromycin by formulating into multiple uni... hiện toàn bộ
Development and Validation of a Simple and Reliable LC-MS/MS Method for the Determination of Acetazolamide, an Effective Carbonic Anhydrase Inhibitor, in Plasma and its Application to a Pharmacokinetic Study
Drug Research - Tập 64 Số 09 - Trang 499-504
Xiang Li, N. Li, C. Wang, Shuhua Deng, Xiang Sun, W. Zhang, Wen Gao, Di Zhao, Yangcheng Lü, X. Chen
Chrysin Alters microRNAs Expression Levels in Gastric Cancer Cells: Possible Molecular Mechanism
Drug Research - Tập 67 Số 09 - Trang 509-514 - 2017
Farideh Mohammadian, Younes Pilehvar‐Soltanahmadi, Shahriar Alipour, Mehdi Dadashpour, Nosratollah Zarghami
Abstract Background Gastric carcinoma still remains the second most common cause of cancer mortality in the world. Chrysin, as a flavone, has showed cancer chemopreventive activity. The cellular and molecular mechanisms of chrysin in cancer cells have not been fully understood. Objective In this study, we investigate expression levels of let-7a, miR-9, mir-18a, miR-21, miR-22, miR-34a, miR-126 and... hiện toàn bộ
Antidiabetic Potentials of Citrus aurantifolia Leaf Essential Oil
Drug Research - Tập 69 Số 04 - Trang 201-206 - 2019
Fatima Ibrahim, L. A. Usman, Jubril Olayinka Akolade, Ayodeji Oluwafemi Idowu, Azeemat Titilola Abdulazeez, Aliyu O. Amuzat
Abstract Citrus aurantifolia leaf essential oil was extracted via hydrodistillation, chemical composition of the oil was analyzed using gas chromatography-mass spectrometry and its antidiabetic potentials was assessed in alloxan-induced hyperglycaemic rats using metformin as the reference drug for comparison. Chemical analysis showed that D-limonene (57.84%) was the major constituent of the oil. O... hiện toàn bộ
A Cautious Note on Thalidomide Usage in Cancer Treatment: Genetic Profiling of the TBX2 Sub-Family Gene Expression is Required
Drug Research - Tập 69 Số 09 - Trang 512-518 - 2019
Georges Nemer, Athar Khalil
AbstractThalidomide is still by excellence the mysterious drug that fascinated, blurred, misled, and changed the scientific community perspectives and policies. It was introduced in the 1950’s as a sedative drug, then shortly withdrawn because of the devastating birth defects that affected tens of thousands throughout more than 40 countries. Back into the market in the mid 1990’s and 2000’s the dr... hiện toàn bộ
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