Dementia and Geriatric Cognitive Disorders

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Atrophy of Hippocampal Formation Subdivisions Correlates with Stage and Duration of Alzheimer Disease
Dementia and Geriatric Cognitive Disorders - Tập 6 Số 4 - Trang 205-210 - 1995
Matthew Bobinski, Jerzy Węgiel, H. M. Wisniewski, Michał Tarnawski, B. Mlodzik, ‌Barry Reisberg, Mony J. de Leon, Douglas C. Miller
The hippocampal formations of 13 subjects with severe Alzheimer disease [AD; Global Deterioration Scale (GDS) stage 7] and of 5 age-matched subjects without symptoms of dementia were reconstructed from serial sections. Functional assessment staging (FAST) was used at the time of demise to assess 9 patients at stages 7a–c (incipient averbal and nonambulatory) and 4 patients at stages 7e–f (...... hiện toàn bộ
Subjective Memory Complaints: Presence, Severity and Future Outcome in Normal Older Subjects
Dementia and Geriatric Cognitive Disorders - Tập 24 Số 3 - Trang 177-184 - 2007
Lidia Głodzik-Sobańska, ‌Barry Reisberg, Susan De Santi, James S. Babb, Elizabeth Pirraglia, Kenneth Rich, Mirosław Bryś, Mony J. de Leon
<i>Background/Aims:</i> Subjective memory complaint (SMC) in normal individuals may predict future cognitive decline. The goal of this study was to examine whether the probability of decline increases with growing intensity of complaint. <i>Methods:</i> Normal subjects over the age of 50 years were included in a longitudinal retrospective study (mean follow-up time ...... hiện toàn bộ
Association between BDNF Polymorphism (Val66Met) and Executive Function in Patients with Amnestic Mild Cognitive Impairment or Mild Alzheimer Disease
Dementia and Geriatric Cognitive Disorders - Tập 33 Số 4 - Trang 266-272 - 2012
Tomoyuki Nagata, Shunichiro Shinagawa, Kazutaka Nukariya, Hisashi Yamada, Kazuhiko Nakayama
Distinctive Clinical Features of Mild Cognitive Impairment with Subcortical Cerebrovascular Disease
Dementia and Geriatric Cognitive Disorders - Tập 19 Số 4 - Trang 196-203 - 2005
Samantha Galluzzi, Ching‐Fan Sheu, Orazio Zanetti, Giovanni B. Frisoni
<i>Background and Purpose:</i> Patients with mild cognitive impairment and subcortical cerebrovascular disease (svMCI) can be isolated using criteria modified from those of Erkinjuntti et al. for subcortical vascular dementia and have poorer outcomes (cognitive deterioration, disability, institutionalization, and mortality). The aim of this study was to test which of the core (...... hiện toàn bộ
Dominant Frontotemporal Dementia Mutations in 140 Cases of Primary Progressive Aphasia and Speech Apraxia
Dementia and Geriatric Cognitive Disorders - Tập 39 Số 5-6 - Trang 281-286 - 2015
Eoin P. Flanagan, Matthew Baker, Ralph B. Perkerson, Joseph R. Duffy, Edythe A. Strand, Jennifer L. Whitwell, Mary M. Machulda, Rosa Rademakers, Keith A. Josephs
<b><i>Background:</i></b> Mutations in three genes [chromosome 9 open-reading-frame 72 <i>(C9ORF72)</i>; microtubule-associated protein tau <i>(MAPT)</i> and progranulin <i>(GRN)</i>] account for the vast majority of familial, and a proportion of sporadic, frontotemporal dementia (FTD) cases. Progressive apraxia of speech (PAOS) i...... hiện toàn bộ
Serum Amyloid P Component as a Biomarker in Mild Cognitive Impairment and Alzheimer’s Disease
Dementia and Geriatric Cognitive Disorders - Tập 26 Số 6 - Trang 522-527 - 2008
Nicolaas A. Verwey, Alie Schuitemaker, Wiesje M. van der Flier, Sandra D. Mulder, Cees Mulder, C. Erik Hack, Philip Scheltens, Marinus A. Blankenstein, Robert Veerhuis
<i>Background:</i> Serum amyloid P component (SAP), present in amyloid-β (Aβ) plaques in Alzheimer’s disease (AD), may protect Aβ deposits against proteolysis, thereby promoting plaque formation. The aim was to investigate if SAP levels in cerebrospinal fluid (CSF) and serum can be used to discriminate controls, AD and mild cognitive impairment (MCI) patients, and to identify i...... hiện toàn bộ
Effects of Physical Activity in Nursing Home Residents with Dementia: A Randomized Controlled Trial
Dementia and Geriatric Cognitive Disorders - Tập 46 Số 1-2 - Trang 60-80 - 2018
Marinda Henskens, Ilse M. Nauta, Marieke C.A. van Eekeren, Erik Scherder
<b><i>Background/Aims:</i></b> There is no consensus regarding the optimal nonpharmacological intervention to slow down dementia-related decline. We examined whether physical stimulation interventions were effective in reducing cognitive, physical, mood, and behavioral decline in nursing home residents with dementia. <b><i>Methods:</i></b> Ei...... hiện toàn bộ
A Systematic Review of Multimodal Non-Pharmacological Interventions for Cognitive Function in Older People with Dementia in Nursing Homes
Dementia and Geriatric Cognitive Disorders - Tập 48 Số 1-2 - Trang 1-16 - 2019
Kyosuke Yorozuya, Yuta Kubo, Naoki Tomiyama, Shingo Yamane, Hideaki Hanaoka
<b><i>Introduction:</i></b> Multimodal non-pharmacological interventions (MNPIs) have been reported to be effective in improving the cognitive function. Therefore, it is necessary to study these interventions in older people with dementia (PWD) in nursing homes (NHs). <b><i>Aims:</i></b> This study aimed to investigate the effects, contents, ...... hiện toàn bộ
Supplemental Use of Antioxidant Vitamins and Subsequent Risk of Cognitive Decline and Dementia
Dementia and Geriatric Cognitive Disorders - Tập 20 Số 1 - Trang 45-51 - 2005
Colleen J. Maxwell, Matthew Hicks, David B. Hogan, Jenny Basran, Erika M. Ebly
There are conflicting reports about the potential role of vitamin antioxidants in preventing and/or slowing the progression of various forms of cognitive impairment including Alzheimer’s disease (AD). We examined longitudinal data from the Canadian Study of Health and Aging, a population-based, prospective 5-year investigation of the epidemiology of dementia among Canadians aged 65+ years....... hiện toàn bộ
Patient and Caregiver Perspectives of Quality of Life in Dementia
Dementia and Geriatric Cognitive Disorders - Tập 26 Số 2 - Trang 138-146 - 2008
Catherine S. Hurt, S. Bhattacharyya, Alistair Burns, Vincent Camus, Rosa Liperoti, Anna Marriott, Flavio Nobili, Philippe Robert, Magda Tsolaki, Bruno Vellas, Frans R.J. Verhey, E. Jane Byrne
<i>Background/Aims:</i> Behavioural and psychological symptoms have a high prevalence amongst patients with dementia and can be a significant source of distress to both patients and carers. The present study explored the relationships between quality of life and behavioural and psychological symptoms in dementia (BPSD) from both patient and carer perspectives. Contextual factor...... hiện toàn bộ
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