Dementia and Geriatric Cognitive Disorders
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Postural Instability Is Associated with Brain Atrophy and Cognitive Impairment in the Elderly: The J-SHIPP Study<i>Background/Aims:</i> Mobility impairment in older adults has been suggested to be a marker of subclinical structural and functional brain abnormalities. We investigated a possible association between static postural instability and brain abnormalities and cognitive decline. <i>Methods:</i> The study subjects were 390 community residents without definitive dementi... ... hiện toàn bộ
Dementia and Geriatric Cognitive Disorders - Tập 29 Số 5 - Trang 379-387 - 2010
Distinctive Clinical Features of Mild Cognitive Impairment with Subcortical Cerebrovascular Disease<i>Background and Purpose:</i> Patients with mild cognitive impairment and subcortical cerebrovascular disease (svMCI) can be isolated using criteria modified from those of Erkinjuntti et al. for subcortical vascular dementia and have poorer outcomes (cognitive deterioration, disability, institutionalization, and mortality). The aim of this study was to test which of the core (... ... hiện toàn bộ
Dementia and Geriatric Cognitive Disorders - Tập 19 Số 4 - Trang 196-203 - 2005
A Novel Panel of Cerebrospinal Fluid Biomarkers for the Differential Diagnosis of Alzheimer’s Disease versus Normal Aging and Frontotemporal Dementia<i>Background:</i> An early and accurate diagnosis of Alzheimer’s disease (AD) is important in order to initiate symptomatic treatment with currently approved drugs and will be of even greater importance with the advent of disease-modifying compounds. <i>Methods:</i> Protein profiles of human cerebrospinal fluid samples from patients with AD (n = 85), frontotemporal... ... hiện toàn bộ
Dementia and Geriatric Cognitive Disorders - Tập 24 Số 6 - Trang 434-440 - 2007
Progression of Mild Cognitive Impairment to Alzheimer’s Disease: Improved Diagnostic Value of the Combined Use of N200 Latency and β-Amyloid(1–42) Levels<i>Background/Aims:</i> The aim of this study was to investigate the role of cerebrospinal fluid β-amyloid(1–42) levels and auditory event-related potentials (AERPs) in the progress of mild cognitive impairment (MCI) to Alzheimer’s disease (AD). <i>Methods:</i> In 53 MCI patients, lumbar puncture was performed and β-amyloid(1–42) levels were determined. Twenty patie... ... hiện toàn bộ
Dementia and Geriatric Cognitive Disorders - Tập 28 Số 1 - Trang 30-35 - 2009
Serum Amyloid P Component as a Biomarker in Mild Cognitive Impairment and Alzheimer’s Disease<i>Background:</i> Serum amyloid P component (SAP), present in amyloid-β (Aβ) plaques in Alzheimer’s disease (AD), may protect Aβ deposits against proteolysis, thereby promoting plaque formation. The aim was to investigate if SAP levels in cerebrospinal fluid (CSF) and serum can be used to discriminate controls, AD and mild cognitive impairment (MCI) patients, and to identify i... ... hiện toàn bộ
Dementia and Geriatric Cognitive Disorders - Tập 26 Số 6 - Trang 522-527 - 2008
Brain Metabolic Correlates of Cerebrospinal Fluid Beta-Amyloid 42 and Tau in Alzheimer’s Disease<i>Background:</i> The cerebrospinal fluid (CSF) proteins β-amyloid 42 (Aβ42) and Tau are believed to indirectly reflect some core pathological features of Alzheimer’s disease (AD). Their topographic origin and their association with synaptic dysfunction are still not well understood. <i>Aim:</i> The present study aimed to explore possible associations between cereb... ... hiện toàn bộ
Dementia and Geriatric Cognitive Disorders - Tập 27 Số 5 - Trang 474-480 - 2009
Measurement of Thirteen Biological Markers in CSF of Patients with Alzheimer’s Disease and Other DementiasCerebrospinal fluid (CSF) biological markers may be of valuable help in the diagnosis of dementia. The aim of the present study was to evaluate CSF levels of 13 potential biomarkers in patients with Alzheimer’s disease (AD), frontotemporal lobe dementia, alcohol dementia, major depression and control patients without any neuropsychiatric disease. The study was performed using β-amyloid 1–4... ... hiện toàn bộ
Dementia and Geriatric Cognitive Disorders - Tập 21 Số 1 - Trang 9-15 - 2006
PET Amyloid Ligand [<sup>11</sup>C]PIB Uptake and Cerebrospinal Fluid β-Amyloid in Mild Cognitive Impairment<i>Background:</i> In mild cognitive impairment (MCI), Alzheimer’s disease (AD)-type cerebrospinal fluid (CSF) biomarker profiles predict rapid progression and conversion to AD. An increased brain amyloid burden in AD and MCI has been demonstrated with PET using [<sup>11</sup>C]PIB (Pittsburgh compound B). Little is known about the relationship between these biomark... ... hiện toàn bộ
Dementia and Geriatric Cognitive Disorders - Tập 26 Số 4 - Trang 378-383 - 2008
Rapid Progression from Mild Cognitive Impairment to Alzheimer’s Disease in Subjects with Elevated Levels of Tau in Cerebrospinal Fluid and the <i>APOE </i>ε<i>4</i>/ε<i>4</i> Genotype<i>Background/Aims:</i> Increased cerebrospinal fluid (CSF) tau, decreased CSF amyloid-β42 (Aβ42) and the apolipoprotein E gene <i>(APOE) </i>ε<i>4</i> allele predict progression from mild cognitive impairment (MCI) to Alzheimer’s disease (AD). Here, we investigated these markers to assess their predictive value and influence on the rate of disease progr... ... hiện toàn bộ
Dementia and Geriatric Cognitive Disorders - Tập 27 Số 5 - Trang 458-464 - 2009
Differential Efficacy of Treatment with Acetylcholinesterase Inhibitors in Patients with Mild and Moderate Alzheimer’s Disease over a 6-Month PeriodThere are various anticholinesterase inhibitors (AChEIs) for the symptomatic treatment of mild to moderate Alzheimer’s disease (AD). All AChEIs have shown greater efficacy than placebo in randomized, double-blind, parallel-group clinical trials. No differential studies have yet been made of the efficacy between all AChEIs. The study aims to determine the differential efficacy of the AChEIs... ... hiện toàn bộ
Dementia and Geriatric Cognitive Disorders - Tập 19 Số 4 - Trang 189-195 - 2005
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