Functional Magnetic Resonance Imaging of Compensatory Neural Recruitment in Aging and Risk for Alzheimer’s Disease: Review and Recommendations

Dementia and Geriatric Cognitive Disorders - Tập 27 Số 1 - Trang 1-10 - 2009
S. Duke Han1, Katherine J. Bangen2, Mark W. Bondi3
1Department of Psychology, Loyola University Chicago, Chicago, Ill., USA.
2SDSU/UCSD Joint Doctoral Program,
3Department of Psychiatry, University of California San Diego School of Medicine, and

Tóm tắt

There has been a recent proliferation of functional magnetic resonance imaging (fMRI) studies that interpret between-group or within-group differences in brain response patterns as evidence for compensatory neural recruitment. However, it is currently a challenge to determine whether these observed differences are truly attributable to compensatory neural recruitment or whether they are indicative of some other cognitive or physiological process. Therefore, the need for a standardized set of criteria for interpreting whether differences in brain response patterns are compensatory in nature is great. Focusing on studies of aging and potentially prodromal Alzheimer’s disease conditions (genetic risk, mild cognitive impairment), we critically review the functional neuroimaging literature purporting evidence for compensatory neural recruitment. Finally, we end with a comprehensive model set of criteria for ascertaining the degree to which a ‘compensatory’ interpretation may be supported. This proposed model addresses significant brain region, activation pattern, and behavioral performance considerations, and is therefore termed the Region-Activation-Performance model (RAP model).

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Dementia and Geriatric Cognitive Disorders

Tập 27 Số 1

1-10

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