Dementia and Geriatric Cognitive Disorders
SCIE-ISI SCOPUS (1990-1992,1994-2025)
1421-9824
1420-8008
Thụy Sĩ
Cơ quản chủ quản: S. Karger AG , KARGER
Lĩnh vực:
Psychiatry and Mental HealthCognitive NeuroscienceGeriatrics and Gerontology
Các bài báo tiêu biểu
Midlife Serum Cholesterol and Increased Risk of Alzheimer’s and Vascular Dementia Three Decades Later
Tập 28 Số 1 - Trang 75-80 - 2009
Aims: To investigate midlife cholesterol in relation to Alzheimer’s
disease (AD) and vascular dementia (VaD) in a large multiethnic cohort of women
and men. Methods: The Kaiser Permanente Northern California Medical Group
(healthcare delivery organization) formed the database for this study. The 9,844
participants underwent detailed health evaluations during 1964–1973 at ages
40–45 y...
The Bayer Activities of Daily Living Scale (B-ADL)
Tập 9 Số Suppl. 2 - Trang 20-26 - 1998
The Bayer Activities of Daily Living Scale (B-ADL) has been developed on an
international basis to assess deficits in the performance of everyday
activities. The scale’s main target group is community dwelling patients who
suffer mild cognitive impairment or mild-to-moderate dementia. It comprises 25
items and takes the form of a questionnaire to be completed by a caregiver or
other informant suff...
Improvement of Episodic Memory in Persons with Mild Cognitive Impairment and Healthy Older Adults: Evidence from a Cognitive Intervention Program
Tập 22 Số 5-6 - Trang 486-499 - 2006
The efficacy of cognitive training was assessed in persons with mild cognitive
impairment (MCI) and persons with normal cognitive aging. Forty-seven
participants were included in this study: 28 with MCI and 17 controls.
Twenty-one participants received intervention (20 MCI and 9 controls) and 16
participants (8 MCI and 8 controls) received no intervention (waiting-list
group). The intervention foc...
Treatment of Alzheimer’s Disease with Clioquinol
Tập 12 Số 6 - Trang 408-414 - 2001
As heavy metal ions may be implicated in the formation of senile plaques in
Alzheimer-afflicted brains, treatment with clioquinol was tested in 20 patients
with Alzheimer’s disease. Clioquinol is a chelator that crosses the blood-brain
barrier and has greater affinity for zinc and copper ions than for calcium and
magnesium ions. Treatment was given for 21 days at doses of 20 mg/day to 10
patients ...
Update on the Neuropathogenesis of Delirium
Tập 10 Số 5 - Trang 330-334 - 1999
Delirium has been considered a syndrome of generalized dysfunction of higher
cortical functions due to its breadth of symptoms and associated diffuse slowing
on electroencephalogram. Advances in neuropsychiatry have revealed differences
between brain regions, including the hemispheres, which may underlie the
constellation of symptoms among different psychiatric disorders. For example,
different ne...
Early-Onset Dementia: Frequency and Causes Compared to Late-Onset Dementia
Tập 21 Số 2 - Trang 59-64 - 2006
Background: Research on the epidemiology of dementia has focused on the
elderly. Few investigations have studied differences in etiologic frequencies
between early-onset dementia (EOD), with onset at an age of less than 65 years
old, and the more common late-onset disorder. Objectives: To determine
relative frequencies and characteristics of EOD versus late-onset dementia (LOD;
age o...
Patient and Caregiver Perspectives of Quality of Life in Dementia
Tập 26 Số 2 - Trang 138-146 - 2008
Background/Aims: Behavioural and psychological symptoms have a high
prevalence amongst patients with dementia and can be a significant source of
distress to both patients and carers. The present study explored the
relationships between quality of life and behavioural and psychological symptoms
in dementia (BPSD) from both patient and carer perspectives. Contextual factors
surrounding the oc...
Subjective Memory Complaints: Presence, Severity and Future Outcome in Normal Older Subjects
Tập 24 Số 3 - Trang 177-184 - 2007
Background/Aims: Subjective memory complaint (SMC) in normal individuals
may predict future cognitive decline. The goal of this study was to examine
whether the probability of decline increases with growing intensity of
complaint. Methods: Normal subjects over the age of 50 years were
included in a longitudinal retrospective study (mean follow-up time = 8 years).
All subjects (n = 23...
Measurement of Thirteen Biological Markers in CSF of Patients with Alzheimer’s Disease and Other Dementias
Tập 21 Số 1 - Trang 9-15 - 2006
Cerebrospinal fluid (CSF) biological markers may be of valuable help in the
diagnosis of dementia. The aim of the present study was to evaluate CSF levels
of 13 potential biomarkers in patients with Alzheimer’s disease (AD),
frontotemporal lobe dementia, alcohol dementia, major depression and control
patients without any neuropsychiatric disease. The study was performed using
β-amyloid 1–42 (Aβ42)...
Rapid Progression from Mild Cognitive Impairment to Alzheimer’s Disease in Subjects with Elevated Levels of Tau in Cerebrospinal Fluid and the <i>APOE </i>ε<i>4</i>/ε<i>4</i> Genotype
Tập 27 Số 5 - Trang 458-464 - 2009
Background/Aims: Increased cerebrospinal fluid (CSF) tau, decreased CSF
amyloid-β42 (Aβ42) and the apolipoprotein E gene (APOE) ε4 allele
predict progression from mild cognitive impairment (MCI) to Alzheimer’s disease
(AD). Here, we investigated these markers to assess their predictive value and
influence on the rate of disease progression. Methods: Using ELISA, we
meas...